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The stationary distribution of allele frequencies when selection acts at unlinked loci.

Research output: Contribution to journalJournal article

Published

Journal publication date11/2006
JournalTheoretical Population Biology
Journal number3
Volume70
Number of pages11
Pages376-386
Original languageEnglish

Abstract

We consider population genetics models where selection acts at a set of unlinked loci. It is known that if the fitness of an individual is multiplicative across loci, then these loci are independent. We consider general selection models, but assume parent-independent mutation at each locus. For such a model, the joint stationary distribution of allele frequencies is proportional to the stationary distribution under neutrality multiplied by a known function of the mean fitness of the population. We further show how knowledge of this stationary distribution enables direct simulation of the genealogy of a sample at a single-locus. For a specific selection model appropriate for complex disease genes, we use simulation to determine what features of the genealogy differ between our general selection model and a multiplicative model.