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The use of DNA double strand break quantification in radiotherapy

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

The use of DNA double strand break quantification in radiotherapy. / McMillan, Trevor J.; Tobi, S.; Mateos, S. et al.
In: International Journal of Radiation Oncology - Biology - Physics, Vol. 49, No. 2, 09.02.2001, p. 373-377.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

McMillan, TJ, Tobi, S, Mateos, S & Lemon, C 2001, 'The use of DNA double strand break quantification in radiotherapy', International Journal of Radiation Oncology - Biology - Physics, vol. 49, no. 2, pp. 373-377. https://doi.org/10.1016/S0360-3016(00)01467-X

APA

McMillan, T. J., Tobi, S., Mateos, S., & Lemon, C. (2001). The use of DNA double strand break quantification in radiotherapy. International Journal of Radiation Oncology - Biology - Physics, 49(2), 373-377. https://doi.org/10.1016/S0360-3016(00)01467-X

Vancouver

McMillan TJ, Tobi S, Mateos S, Lemon C. The use of DNA double strand break quantification in radiotherapy. International Journal of Radiation Oncology - Biology - Physics. 2001 Feb 9;49(2):373-377. doi: 10.1016/S0360-3016(00)01467-X

Author

McMillan, Trevor J. ; Tobi, S. ; Mateos, S. et al. / The use of DNA double strand break quantification in radiotherapy. In: International Journal of Radiation Oncology - Biology - Physics. 2001 ; Vol. 49, No. 2. pp. 373-377.

Bibtex

@article{2574d9a9a13b498596d4c07d928f1ca2,
title = "The use of DNA double strand break quantification in radiotherapy",
abstract = "DNA double-strand breaks (DSB) are an important direct consequence of treating cells with ionizingradiation. A variety of evidence points toward DSBs being the key damage type linked to radiation-induced lethality. In particular, the link between DSB and chromosome breakage, which in turn closely correlates with cell death in some cell types, is strongly supportive of this concept. There has been much interest in the possibility of using measures of strand breaks as a pretreatment test of radiation response. This has largely been in the context of assessing inherent cellular sensitivity through damage induction or repair parameters. A number of studies have produced hopeful results, but overall there has been no parameter that can reliably predict radiosensitivity. This may be due to the inadequacies of the assays, but it is more likely to reflect the fact that the radiosensitivity of cells is dictated by a whole series of events; alterations in many of these can alter the overall response. In addition, it is now recognized that cell-signalling pathways form an essential part of the cellular response to damage, and these can be triggered by damage other than DSB. It is therefore possible that while DSBs are clearly important—and they may be the single most important lesion in some types—other damage types may be significant triggers of cell death pathways after ionizing radiation treatment.",
keywords = "Radiation, Double-strand break, Repair, Damage",
author = "McMillan, {Trevor J.} and S. Tobi and S. Mateos and C. Lemon",
note = "The final, definitive version of this article has been published in the Journal, International Journal Radiation Oncology Biology Physics, 49 (2), 2001, {\textcopyright} ELSEVIER.",
year = "2001",
month = feb,
day = "9",
doi = "10.1016/S0360-3016(00)01467-X",
language = "English",
volume = "49",
pages = "373--377",
journal = "International Journal of Radiation Oncology - Biology - Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - The use of DNA double strand break quantification in radiotherapy

AU - McMillan, Trevor J.

AU - Tobi, S.

AU - Mateos, S.

AU - Lemon, C.

N1 - The final, definitive version of this article has been published in the Journal, International Journal Radiation Oncology Biology Physics, 49 (2), 2001, © ELSEVIER.

PY - 2001/2/9

Y1 - 2001/2/9

N2 - DNA double-strand breaks (DSB) are an important direct consequence of treating cells with ionizingradiation. A variety of evidence points toward DSBs being the key damage type linked to radiation-induced lethality. In particular, the link between DSB and chromosome breakage, which in turn closely correlates with cell death in some cell types, is strongly supportive of this concept. There has been much interest in the possibility of using measures of strand breaks as a pretreatment test of radiation response. This has largely been in the context of assessing inherent cellular sensitivity through damage induction or repair parameters. A number of studies have produced hopeful results, but overall there has been no parameter that can reliably predict radiosensitivity. This may be due to the inadequacies of the assays, but it is more likely to reflect the fact that the radiosensitivity of cells is dictated by a whole series of events; alterations in many of these can alter the overall response. In addition, it is now recognized that cell-signalling pathways form an essential part of the cellular response to damage, and these can be triggered by damage other than DSB. It is therefore possible that while DSBs are clearly important—and they may be the single most important lesion in some types—other damage types may be significant triggers of cell death pathways after ionizing radiation treatment.

AB - DNA double-strand breaks (DSB) are an important direct consequence of treating cells with ionizingradiation. A variety of evidence points toward DSBs being the key damage type linked to radiation-induced lethality. In particular, the link between DSB and chromosome breakage, which in turn closely correlates with cell death in some cell types, is strongly supportive of this concept. There has been much interest in the possibility of using measures of strand breaks as a pretreatment test of radiation response. This has largely been in the context of assessing inherent cellular sensitivity through damage induction or repair parameters. A number of studies have produced hopeful results, but overall there has been no parameter that can reliably predict radiosensitivity. This may be due to the inadequacies of the assays, but it is more likely to reflect the fact that the radiosensitivity of cells is dictated by a whole series of events; alterations in many of these can alter the overall response. In addition, it is now recognized that cell-signalling pathways form an essential part of the cellular response to damage, and these can be triggered by damage other than DSB. It is therefore possible that while DSBs are clearly important—and they may be the single most important lesion in some types—other damage types may be significant triggers of cell death pathways after ionizing radiation treatment.

KW - Radiation

KW - Double-strand break

KW - Repair

KW - Damage

U2 - 10.1016/S0360-3016(00)01467-X

DO - 10.1016/S0360-3016(00)01467-X

M3 - Journal article

VL - 49

SP - 373

EP - 377

JO - International Journal of Radiation Oncology - Biology - Physics

JF - International Journal of Radiation Oncology - Biology - Physics

SN - 0360-3016

IS - 2

ER -