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Therapeutic potential of flavonoids in spinal cord injury

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Therapeutic potential of flavonoids in spinal cord injury. / Zhang, Peng; Holscher, Christian; Ma, Xun.
In: Reviews in the Neurosciences, Vol. 28, No. 1, 01.2017, p. 87-101.

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Zhang P, Holscher C, Ma X. Therapeutic potential of flavonoids in spinal cord injury. Reviews in the Neurosciences. 2017 Jan;28(1):87-101. Epub 2017 Jan 3. doi: 10.1515/revneuro-2016-0053

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Zhang, Peng ; Holscher, Christian ; Ma, Xun. / Therapeutic potential of flavonoids in spinal cord injury. In: Reviews in the Neurosciences. 2017 ; Vol. 28, No. 1. pp. 87-101.

Bibtex

@article{d9dac6b44694489fba053178453f2b04,
title = "Therapeutic potential of flavonoids in spinal cord injury",
abstract = "Spinal cord injury (SCI) is a catastrophic event that can profoundly affect a patient's life, with far-reaching social and economic effects. A consequential sequence of SCI is the significant neurological or psychological deficit, which obviously contributes to the overall burden of this condition. To date, there is no effective treatment for SCI. Therefore, developing novel therapeutic strategies for SCI is highly prioritized. Flavonoids, one of the most numerous and ubiquitous groups of plant metabolites, are the active ingredients of traditional Chinese medicine such as Scutellaria baicalensis Georgi (Huang Qin) or Ginkgo biloba (Ying Xin). Accumulated research data show that flavonoids possess a range of key pharmacological properties such as anti-inflammatory, anti-oxidant, anti-tumor, anti-viral, anti-cardiovascular disease, immunomodulatory, and neuroprotective effects. Based on this, the flavonoids show therapeutic potential for SCI diseases. In this paper, we will review the pharmacological properties of different types of flavonoids for the treatment of SCI diseases, and potential underlying biochemical mechanisms of action will also be described.",
keywords = "anti-apoptosis, anti-inflammatory, anti-oxidants, flavonoids, neuroprotection, pharmacology, spinal cord injury, HYDROXYSAFFLOR YELLOW-A, MESENCHYMAL STEM-CELLS, SCUTELLARIA-BAICALENSIS-GEORGI, CEREBRAL-ARTERY OCCLUSION, OXIDATIVE STRESS, FUNCTIONAL RECOVERY, GINKGO-BILOBA, EPIGALLOCATECHIN GALLATE, LIPID-PEROXIDATION, ANIMAL-MODEL",
author = "Peng Zhang and Christian Holscher and Xun Ma",
note = "{\textcopyright}2017 Walter de Gruyter GmbH, Berlin/Boston.",
year = "2017",
month = jan,
doi = "10.1515/revneuro-2016-0053",
language = "English",
volume = "28",
pages = "87--101",
journal = "Reviews in the Neurosciences",
issn = "0334-1763",
publisher = "WALTER DE GRUYTER GMBH",
number = "1",

}

RIS

TY - JOUR

T1 - Therapeutic potential of flavonoids in spinal cord injury

AU - Zhang, Peng

AU - Holscher, Christian

AU - Ma, Xun

N1 - ©2017 Walter de Gruyter GmbH, Berlin/Boston.

PY - 2017/1

Y1 - 2017/1

N2 - Spinal cord injury (SCI) is a catastrophic event that can profoundly affect a patient's life, with far-reaching social and economic effects. A consequential sequence of SCI is the significant neurological or psychological deficit, which obviously contributes to the overall burden of this condition. To date, there is no effective treatment for SCI. Therefore, developing novel therapeutic strategies for SCI is highly prioritized. Flavonoids, one of the most numerous and ubiquitous groups of plant metabolites, are the active ingredients of traditional Chinese medicine such as Scutellaria baicalensis Georgi (Huang Qin) or Ginkgo biloba (Ying Xin). Accumulated research data show that flavonoids possess a range of key pharmacological properties such as anti-inflammatory, anti-oxidant, anti-tumor, anti-viral, anti-cardiovascular disease, immunomodulatory, and neuroprotective effects. Based on this, the flavonoids show therapeutic potential for SCI diseases. In this paper, we will review the pharmacological properties of different types of flavonoids for the treatment of SCI diseases, and potential underlying biochemical mechanisms of action will also be described.

AB - Spinal cord injury (SCI) is a catastrophic event that can profoundly affect a patient's life, with far-reaching social and economic effects. A consequential sequence of SCI is the significant neurological or psychological deficit, which obviously contributes to the overall burden of this condition. To date, there is no effective treatment for SCI. Therefore, developing novel therapeutic strategies for SCI is highly prioritized. Flavonoids, one of the most numerous and ubiquitous groups of plant metabolites, are the active ingredients of traditional Chinese medicine such as Scutellaria baicalensis Georgi (Huang Qin) or Ginkgo biloba (Ying Xin). Accumulated research data show that flavonoids possess a range of key pharmacological properties such as anti-inflammatory, anti-oxidant, anti-tumor, anti-viral, anti-cardiovascular disease, immunomodulatory, and neuroprotective effects. Based on this, the flavonoids show therapeutic potential for SCI diseases. In this paper, we will review the pharmacological properties of different types of flavonoids for the treatment of SCI diseases, and potential underlying biochemical mechanisms of action will also be described.

KW - anti-apoptosis

KW - anti-inflammatory

KW - anti-oxidants

KW - flavonoids

KW - neuroprotection

KW - pharmacology

KW - spinal cord injury

KW - HYDROXYSAFFLOR YELLOW-A

KW - MESENCHYMAL STEM-CELLS

KW - SCUTELLARIA-BAICALENSIS-GEORGI

KW - CEREBRAL-ARTERY OCCLUSION

KW - OXIDATIVE STRESS

KW - FUNCTIONAL RECOVERY

KW - GINKGO-BILOBA

KW - EPIGALLOCATECHIN GALLATE

KW - LIPID-PEROXIDATION

KW - ANIMAL-MODEL

U2 - 10.1515/revneuro-2016-0053

DO - 10.1515/revneuro-2016-0053

M3 - Journal article

VL - 28

SP - 87

EP - 101

JO - Reviews in the Neurosciences

JF - Reviews in the Neurosciences

SN - 0334-1763

IS - 1

ER -