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Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies

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Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies. / Bates, Paul A.

In: International Journal for Parasitology, Vol. 37, No. 10, 2007, p. 1097-1106.

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Bates, Paul A. / Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies. In: International Journal for Parasitology. 2007 ; Vol. 37, No. 10. pp. 1097-1106.

Bibtex

@article{8c393c6a782b4f3f927e89a903601483,
title = "Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies",
abstract = "A thorough understanding of the transmission mechanism of any infectious agent is crucial to implementing an effective intervention strategy. Here, our current understanding of the mechanisms that Leishmania parasites use to ensure their transmission from sand fly vectors by bite is reviewed. The most important mechanism is the creation of a {"}blocked fly{"} resulting from the secretion of promastigote secretory gel (PSG) by the parasites in the anterior midgut. This forces the sand fly to regurgitate PSG before it can bloodfeed, thereby depositing both PSG and infective metacyclic promastigotes in the skin of a mammalian host. Other possible factors in transmission are considered: damage to the stomodeal valve; occurrence of parasites in the salivary glands; and excretion of parasites from the anus of infected sand flies. Differences in the transmission mechanisms employed by parasites in the three subgenera, Leishmania, Viannia and Sauroleishmania are also addressed.",
keywords = "Leishmania, Viannia , Life cycle , Promastigote secretory gel , Metacyclic promastigotes , Regurgitation , Sand fly , Saliva",
author = "Bates, {Paul A}",
year = "2007",
doi = "10.1016/j.ijpara.2007.04.003",
language = "English",
volume = "37",
pages = "1097--1106",
journal = "International Journal for Parasitology",
issn = "0020-7519",
publisher = "Elsevier Limited",
number = "10",

}

RIS

TY - JOUR

T1 - Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies

AU - Bates, Paul A

PY - 2007

Y1 - 2007

N2 - A thorough understanding of the transmission mechanism of any infectious agent is crucial to implementing an effective intervention strategy. Here, our current understanding of the mechanisms that Leishmania parasites use to ensure their transmission from sand fly vectors by bite is reviewed. The most important mechanism is the creation of a "blocked fly" resulting from the secretion of promastigote secretory gel (PSG) by the parasites in the anterior midgut. This forces the sand fly to regurgitate PSG before it can bloodfeed, thereby depositing both PSG and infective metacyclic promastigotes in the skin of a mammalian host. Other possible factors in transmission are considered: damage to the stomodeal valve; occurrence of parasites in the salivary glands; and excretion of parasites from the anus of infected sand flies. Differences in the transmission mechanisms employed by parasites in the three subgenera, Leishmania, Viannia and Sauroleishmania are also addressed.

AB - A thorough understanding of the transmission mechanism of any infectious agent is crucial to implementing an effective intervention strategy. Here, our current understanding of the mechanisms that Leishmania parasites use to ensure their transmission from sand fly vectors by bite is reviewed. The most important mechanism is the creation of a "blocked fly" resulting from the secretion of promastigote secretory gel (PSG) by the parasites in the anterior midgut. This forces the sand fly to regurgitate PSG before it can bloodfeed, thereby depositing both PSG and infective metacyclic promastigotes in the skin of a mammalian host. Other possible factors in transmission are considered: damage to the stomodeal valve; occurrence of parasites in the salivary glands; and excretion of parasites from the anus of infected sand flies. Differences in the transmission mechanisms employed by parasites in the three subgenera, Leishmania, Viannia and Sauroleishmania are also addressed.

KW - Leishmania

KW - Viannia

KW - Life cycle

KW - Promastigote secretory gel

KW - Metacyclic promastigotes

KW - Regurgitation

KW - Sand fly

KW - Saliva

U2 - 10.1016/j.ijpara.2007.04.003

DO - 10.1016/j.ijpara.2007.04.003

M3 - Journal article

VL - 37

SP - 1097

EP - 1106

JO - International Journal for Parasitology

JF - International Journal for Parasitology

SN - 0020-7519

IS - 10

ER -