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Type I interferon is required for T helper (Th) 2 induction by dendritic cells

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Type I interferon is required for T helper (Th) 2 induction by dendritic cells. / Webb, Lauren M; Lundie, Rachel J; Borger, Jessica G et al.
In: EMBO Journal, Vol. 36, No. 16, 15.08.2017, p. 2404-2418.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Webb, LM, Lundie, RJ, Borger, JG, Brown, SL, Connor, LM, Cartwright, AN, Dougall, AM, Wilbers, RH, Cook, PC, Jackson-Jones, LH, Phythian-Adams, AT, Johansson, C, Davis, DM, Dewals, BG, Ronchese, F & MacDonald, AS 2017, 'Type I interferon is required for T helper (Th) 2 induction by dendritic cells', EMBO Journal, vol. 36, no. 16, pp. 2404-2418. https://doi.org/10.15252/embj.201695345

APA

Webb, L. M., Lundie, R. J., Borger, J. G., Brown, S. L., Connor, L. M., Cartwright, A. N., Dougall, A. M., Wilbers, R. H., Cook, P. C., Jackson-Jones, L. H., Phythian-Adams, A. T., Johansson, C., Davis, D. M., Dewals, B. G., Ronchese, F., & MacDonald, A. S. (2017). Type I interferon is required for T helper (Th) 2 induction by dendritic cells. EMBO Journal, 36(16), 2404-2418. https://doi.org/10.15252/embj.201695345

Vancouver

Webb LM, Lundie RJ, Borger JG, Brown SL, Connor LM, Cartwright AN et al. Type I interferon is required for T helper (Th) 2 induction by dendritic cells. EMBO Journal. 2017 Aug 15;36(16):2404-2418. Epub 2017 Jul 17. doi: 10.15252/embj.201695345

Author

Webb, Lauren M ; Lundie, Rachel J ; Borger, Jessica G et al. / Type I interferon is required for T helper (Th) 2 induction by dendritic cells. In: EMBO Journal. 2017 ; Vol. 36, No. 16. pp. 2404-2418.

Bibtex

@article{16099fadb11e4323a2476755c23c7b55,
title = "Type I interferon is required for T helper (Th) 2 induction by dendritic cells",
abstract = "Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies. However, the precise mechanisms involved in T helper (Th) 2 polarization by dendritic cells (DCs) are currently unclear. We have identified a previously unrecognized role for type I IFN (IFN-I) in enabling this process. An IFN-I signature was evident in DCs responding to the helminth Schistosoma mansoni or the allergen house dust mite (HDM). Further, IFN-I signaling was required for optimal DC phenotypic activation in response to helminth antigen (Ag), and efficient migration to, and localization with, T cells in the draining lymph node (dLN). Importantly, DCs generated from Ifnar1-/- mice were incapable of initiating Th2 responses in vivo These data demonstrate for the first time that the influence of IFN-I is not limited to antiviral or bacterial settings but also has a central role to play in DC initiation of Th2 responses.",
keywords = "Allergens, Animals, Dendritic Cells, Interferon Type I, Mice, Mice, Knockout, Pyroglyphidae, Receptor, Interferon alpha-beta, Schistosoma mansoni, Th2 Cells, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Webb, {Lauren M} and Lundie, {Rachel J} and Borger, {Jessica G} and Brown, {Sheila L} and Connor, {Lisa M} and Cartwright, {Adam Nr} and Dougall, {Annette M} and Wilbers, {Ruud Hp} and Cook, {Peter C} and Jackson-Jones, {Lucy H} and Phythian-Adams, {Alexander T} and Cecilia Johansson and Davis, {Daniel M} and Dewals, {Benjamin G} and Franca Ronchese and MacDonald, {Andrew S}",
note = "{\textcopyright} 2017 The Authors. Published under the terms of the CC BY 4.0 license.",
year = "2017",
month = aug,
day = "15",
doi = "10.15252/embj.201695345",
language = "English",
volume = "36",
pages = "2404--2418",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "Nature Publishing Group",
number = "16",

}

RIS

TY - JOUR

T1 - Type I interferon is required for T helper (Th) 2 induction by dendritic cells

AU - Webb, Lauren M

AU - Lundie, Rachel J

AU - Borger, Jessica G

AU - Brown, Sheila L

AU - Connor, Lisa M

AU - Cartwright, Adam Nr

AU - Dougall, Annette M

AU - Wilbers, Ruud Hp

AU - Cook, Peter C

AU - Jackson-Jones, Lucy H

AU - Phythian-Adams, Alexander T

AU - Johansson, Cecilia

AU - Davis, Daniel M

AU - Dewals, Benjamin G

AU - Ronchese, Franca

AU - MacDonald, Andrew S

N1 - © 2017 The Authors. Published under the terms of the CC BY 4.0 license.

PY - 2017/8/15

Y1 - 2017/8/15

N2 - Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies. However, the precise mechanisms involved in T helper (Th) 2 polarization by dendritic cells (DCs) are currently unclear. We have identified a previously unrecognized role for type I IFN (IFN-I) in enabling this process. An IFN-I signature was evident in DCs responding to the helminth Schistosoma mansoni or the allergen house dust mite (HDM). Further, IFN-I signaling was required for optimal DC phenotypic activation in response to helminth antigen (Ag), and efficient migration to, and localization with, T cells in the draining lymph node (dLN). Importantly, DCs generated from Ifnar1-/- mice were incapable of initiating Th2 responses in vivo These data demonstrate for the first time that the influence of IFN-I is not limited to antiviral or bacterial settings but also has a central role to play in DC initiation of Th2 responses.

AB - Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies. However, the precise mechanisms involved in T helper (Th) 2 polarization by dendritic cells (DCs) are currently unclear. We have identified a previously unrecognized role for type I IFN (IFN-I) in enabling this process. An IFN-I signature was evident in DCs responding to the helminth Schistosoma mansoni or the allergen house dust mite (HDM). Further, IFN-I signaling was required for optimal DC phenotypic activation in response to helminth antigen (Ag), and efficient migration to, and localization with, T cells in the draining lymph node (dLN). Importantly, DCs generated from Ifnar1-/- mice were incapable of initiating Th2 responses in vivo These data demonstrate for the first time that the influence of IFN-I is not limited to antiviral or bacterial settings but also has a central role to play in DC initiation of Th2 responses.

KW - Allergens

KW - Animals

KW - Dendritic Cells

KW - Interferon Type I

KW - Mice

KW - Mice, Knockout

KW - Pyroglyphidae

KW - Receptor, Interferon alpha-beta

KW - Schistosoma mansoni

KW - Th2 Cells

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.15252/embj.201695345

DO - 10.15252/embj.201695345

M3 - Journal article

C2 - 28716804

VL - 36

SP - 2404

EP - 2418

JO - EMBO Journal

JF - EMBO Journal

SN - 0261-4189

IS - 16

ER -