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Ultrasound induced fluorescence of nanoscale liposome contrast agents

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Ultrasound induced fluorescence of nanoscale liposome contrast agents. / Zhang, Qimei; Morgan, Stephen P.; O'Shea, Paul et al.
In: PLoS ONE, Vol. 11, No. 7, e0159742, 28.07.2016.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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APA

Zhang, Q., Morgan, S. P., O'Shea, P., & Mather, M. L. (2016). Ultrasound induced fluorescence of nanoscale liposome contrast agents. PLoS ONE, 11(7), Article e0159742. https://doi.org/10.1371/journal.pone.0159742

Vancouver

Zhang Q, Morgan SP, O'Shea P, Mather ML. Ultrasound induced fluorescence of nanoscale liposome contrast agents. PLoS ONE. 2016 Jul 28;11(7):e0159742. doi: 10.1371/journal.pone.0159742

Author

Zhang, Qimei ; Morgan, Stephen P. ; O'Shea, Paul et al. / Ultrasound induced fluorescence of nanoscale liposome contrast agents. In: PLoS ONE. 2016 ; Vol. 11, No. 7.

Bibtex

@article{965c790af96c47498ea38a1a7b760f5e,
title = "Ultrasound induced fluorescence of nanoscale liposome contrast agents",
abstract = "A new imaging contrast agent is reported that provides an increased fluorescent signal upon application of ultrasound (US). Liposomes containing lipids labelled with pyrene were optically excited and the excimer fluorescence emission intensity was detected in the absence and presence of an ultrasound field using an acousto-fluorescence setup. The acousto-fluorescence dynamics of liposomes containing lipids with pyrene labelled on the fatty acid tail group (PyPC) and the head group (PyPE) were compared. An increase in excimer emission intensity following exposure to US was observed for both cases studied. The increased intensity and time constants were found to be different for the PyPC and PyPE systems, and dependent on the applied US pressure and exposure time. The greatest change in fluorescence intensity (130%) and smallest rise time constant (0.33 s) are achieved through the use of PyPC labelled liposomes. The mechanism underlying the observed increase of the excimer emission intensity in PyPC labelled liposomes is proposed to arise from the {"}wagging{"} of acyl chains which involves fast response and requires lower US pressure. This is accompanied by increased lipid lateral diffusivity at higher ultrasound pressures, a mechanism that is also active in the PyPE labelled liposomes.",
author = "Qimei Zhang and Morgan, {Stephen P.} and Paul O'Shea and Mather, {Melissa L.}",
year = "2016",
month = jul,
day = "28",
doi = "10.1371/journal.pone.0159742",
language = "English",
volume = "11",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Ultrasound induced fluorescence of nanoscale liposome contrast agents

AU - Zhang, Qimei

AU - Morgan, Stephen P.

AU - O'Shea, Paul

AU - Mather, Melissa L.

PY - 2016/7/28

Y1 - 2016/7/28

N2 - A new imaging contrast agent is reported that provides an increased fluorescent signal upon application of ultrasound (US). Liposomes containing lipids labelled with pyrene were optically excited and the excimer fluorescence emission intensity was detected in the absence and presence of an ultrasound field using an acousto-fluorescence setup. The acousto-fluorescence dynamics of liposomes containing lipids with pyrene labelled on the fatty acid tail group (PyPC) and the head group (PyPE) were compared. An increase in excimer emission intensity following exposure to US was observed for both cases studied. The increased intensity and time constants were found to be different for the PyPC and PyPE systems, and dependent on the applied US pressure and exposure time. The greatest change in fluorescence intensity (130%) and smallest rise time constant (0.33 s) are achieved through the use of PyPC labelled liposomes. The mechanism underlying the observed increase of the excimer emission intensity in PyPC labelled liposomes is proposed to arise from the "wagging" of acyl chains which involves fast response and requires lower US pressure. This is accompanied by increased lipid lateral diffusivity at higher ultrasound pressures, a mechanism that is also active in the PyPE labelled liposomes.

AB - A new imaging contrast agent is reported that provides an increased fluorescent signal upon application of ultrasound (US). Liposomes containing lipids labelled with pyrene were optically excited and the excimer fluorescence emission intensity was detected in the absence and presence of an ultrasound field using an acousto-fluorescence setup. The acousto-fluorescence dynamics of liposomes containing lipids with pyrene labelled on the fatty acid tail group (PyPC) and the head group (PyPE) were compared. An increase in excimer emission intensity following exposure to US was observed for both cases studied. The increased intensity and time constants were found to be different for the PyPC and PyPE systems, and dependent on the applied US pressure and exposure time. The greatest change in fluorescence intensity (130%) and smallest rise time constant (0.33 s) are achieved through the use of PyPC labelled liposomes. The mechanism underlying the observed increase of the excimer emission intensity in PyPC labelled liposomes is proposed to arise from the "wagging" of acyl chains which involves fast response and requires lower US pressure. This is accompanied by increased lipid lateral diffusivity at higher ultrasound pressures, a mechanism that is also active in the PyPE labelled liposomes.

U2 - 10.1371/journal.pone.0159742

DO - 10.1371/journal.pone.0159742

M3 - Journal article

VL - 11

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 7

M1 - e0159742

ER -