Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Variability of β-amyloid protein deposited lesions in Down's syndrome brains
AU - Ikeda, S
AU - Tokuda, T
AU - Yanagisawa, N
AU - Kametani, F
AU - Ohshima, T
AU - Allsop, D
PY - 1994
Y1 - 1994
N2 - An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.
AB - An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.
KW - Adult
KW - Alzheimer Disease
KW - Amyloid beta-Peptides
KW - Amyloid beta-Protein Precursor
KW - Brain
KW - Brain Chemistry
KW - Cerebral Amyloid Angiopathy
KW - Down Syndrome
KW - Female
KW - Humans
KW - Immunoenzyme Techniques
KW - Male
KW - Middle Aged
KW - Nerve Degeneration
KW - Nerve Tissue Proteins
KW - Neurites
KW - Neurofibrillary Tangles
KW - Peptide Fragments
KW - RNA Splicing
KW - tau Proteins
M3 - Journal article
C2 - 7761984
VL - 174
SP - 189
EP - 198
JO - The Tohoku Journal of Experimental Medicine
JF - The Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 3
ER -