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Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization. / Adams, Dave J.; Atkins, Derek; Cooper, Andrew I. et al.
In: Biomacromolecules, Vol. 9, No. 11, 11.2008, p. 2997-3003.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Adams, DJ, Atkins, D, Cooper, AI, Furzeland, S, Trewin, A & Young, I 2008, 'Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization', Biomacromolecules, vol. 9, no. 11, pp. 2997-3003. https://doi.org/10.1021/bm8006693

APA

Adams, D. J., Atkins, D., Cooper, A. I., Furzeland, S., Trewin, A., & Young, I. (2008). Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization. Biomacromolecules, 9(11), 2997-3003. https://doi.org/10.1021/bm8006693

Vancouver

Adams DJ, Atkins D, Cooper AI, Furzeland S, Trewin A, Young I. Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization. Biomacromolecules. 2008 Nov;9(11):2997-3003. doi: 10.1021/bm8006693

Author

Adams, Dave J. ; Atkins, Derek ; Cooper, Andrew I. et al. / Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization. In: Biomacromolecules. 2008 ; Vol. 9, No. 11. pp. 2997-3003.

Bibtex

@article{b5edbdf3d5b8425b9b9ff1b98bb452d7,
title = "Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization",
abstract = "Block copolymers can adopt a wide range of morphologies in dilute aqueous solution. There is a significant amount of interest in the use of block copolymer vesicles for a number of applications. We show that a series of oligo(valine) and oligo(phenylalanine) peptides coupled to a methacrylic group can be prepared by conventional peptide coupling techniques. These can be successfully polymerized by atom transfer radical polymerization (ATPP) in hexafluoroisopropanol (HFIP) giving access to poly(ethylene oxide)-b-poly(side-chain peptides). Many of these polymers self-assemble to form vesicles using an organic to aqueous solvent exchange. One example with a divaline hydrophobic block gives a mixture of toroids and vesicles. Circular dichroism demonstrates that secondary structuring is observed in the hydrophobic region of the vesicle walls for the valine side-chain containing polymers.",
keywords = "BLOCK-COPOLYMER VESICLES, TRANSMISSION ELECTRON-MICROSCOPY, STIMULI-RESPONSIVE VESICLES, DIBLOCK COPOLYMERS, BETA-SHEET, BIODEGRADABLE POLYMERSOMES, DEFINED POLYPEPTIDES, TRIBLOCK COPOLYMERS, LENGTH DISTRIBUTION, DILUTE-SOLUTION",
author = "Adams, {Dave J.} and Derek Atkins and Cooper, {Andrew I.} and Steve Furzeland and Abbie Trewin and Iain Young",
year = "2008",
month = nov,
doi = "10.1021/bm8006693",
language = "English",
volume = "9",
pages = "2997--3003",
journal = "Biomacromolecules",
issn = "1525-7797",
publisher = "American Chemical Society",
number = "11",

}

RIS

TY - JOUR

T1 - Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization

AU - Adams, Dave J.

AU - Atkins, Derek

AU - Cooper, Andrew I.

AU - Furzeland, Steve

AU - Trewin, Abbie

AU - Young, Iain

PY - 2008/11

Y1 - 2008/11

N2 - Block copolymers can adopt a wide range of morphologies in dilute aqueous solution. There is a significant amount of interest in the use of block copolymer vesicles for a number of applications. We show that a series of oligo(valine) and oligo(phenylalanine) peptides coupled to a methacrylic group can be prepared by conventional peptide coupling techniques. These can be successfully polymerized by atom transfer radical polymerization (ATPP) in hexafluoroisopropanol (HFIP) giving access to poly(ethylene oxide)-b-poly(side-chain peptides). Many of these polymers self-assemble to form vesicles using an organic to aqueous solvent exchange. One example with a divaline hydrophobic block gives a mixture of toroids and vesicles. Circular dichroism demonstrates that secondary structuring is observed in the hydrophobic region of the vesicle walls for the valine side-chain containing polymers.

AB - Block copolymers can adopt a wide range of morphologies in dilute aqueous solution. There is a significant amount of interest in the use of block copolymer vesicles for a number of applications. We show that a series of oligo(valine) and oligo(phenylalanine) peptides coupled to a methacrylic group can be prepared by conventional peptide coupling techniques. These can be successfully polymerized by atom transfer radical polymerization (ATPP) in hexafluoroisopropanol (HFIP) giving access to poly(ethylene oxide)-b-poly(side-chain peptides). Many of these polymers self-assemble to form vesicles using an organic to aqueous solvent exchange. One example with a divaline hydrophobic block gives a mixture of toroids and vesicles. Circular dichroism demonstrates that secondary structuring is observed in the hydrophobic region of the vesicle walls for the valine side-chain containing polymers.

KW - BLOCK-COPOLYMER VESICLES

KW - TRANSMISSION ELECTRON-MICROSCOPY

KW - STIMULI-RESPONSIVE VESICLES

KW - DIBLOCK COPOLYMERS

KW - BETA-SHEET

KW - BIODEGRADABLE POLYMERSOMES

KW - DEFINED POLYPEPTIDES

KW - TRIBLOCK COPOLYMERS

KW - LENGTH DISTRIBUTION

KW - DILUTE-SOLUTION

U2 - 10.1021/bm8006693

DO - 10.1021/bm8006693

M3 - Journal article

VL - 9

SP - 2997

EP - 3003

JO - Biomacromolecules

JF - Biomacromolecules

SN - 1525-7797

IS - 11

ER -