Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Volumetric neural correlates of antisaccade eye movements in first-episode psychosis.
AU - Ettinger, Ulrich
AU - Kumari, Veena
AU - Chitnis, Xavier A.
AU - Corr, Philip J.
AU - Crawford, Trevor J.
AU - Fannon, Dominic G.
AU - O’Ceallaigh, Séamus
AU - Sumich, Alex L.
AU - Doku, Victor C.
AU - Sharma, Tonmoy
PY - 2004/10
Y1 - 2004/10
N2 - OBJECTIVE: The authors investigated the structural brain correlates of antisaccade performance. METHOD: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography. RESULTS: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate. CONCLUSIONS: These findings point to altered structure-function relationships in first-episode psychosis.
AB - OBJECTIVE: The authors investigated the structural brain correlates of antisaccade performance. METHOD: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography. RESULTS: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate. CONCLUSIONS: These findings point to altered structure-function relationships in first-episode psychosis.
M3 - Journal article
VL - 161
SP - 1918
EP - 1921
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 1535-7228
IS - 10
ER -