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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Wavelet analysis of blood flow dynamics
T2 - effect on the individual oscillatory components of iontophoresis with pharmacologically neutral electrolytes
AU - Veber, Mitja
AU - Bandrivskyy, Andriy
AU - Clarkson, Peter B. M.
AU - McClintock, Peter V. E.
AU - Stefanovska, Aneta
PY - 2004/4/21
Y1 - 2004/4/21
N2 - Iontophoresis currents are used in the transcutaneous delivery of vasoactive substances for noninvasive assessment of skin vascular properties. The blood flow rate can be recorded by laser Doppler flowmetry (LDF), its average value and the amplitudes of its oscillatory components being used to evaluate the effect of the drugs. Because non-drug-specific, current-induced, vasodilation could confound the interpretation of the response, we have investigated the effect of currents of both polarities on the spectral components of the LDF signal in the absence of vasoactive substances. It was recorded for healthy volunteers with both high conductance (5 mol/l NaCl) and low conductance (deionized water) electrolytes. The oscillatory components were analysed by wavelet transform within 0.0095–1.6 Hz, divided into five sub-intervals. Only cathodal iontophoresis with deionized water increased the oscillatory energy and amplitude. It did so at all frequencies, but none of the sub-intervals associated with vasodilation (0.0095–0.145 Hz) was selectively affected compared to the others.
AB - Iontophoresis currents are used in the transcutaneous delivery of vasoactive substances for noninvasive assessment of skin vascular properties. The blood flow rate can be recorded by laser Doppler flowmetry (LDF), its average value and the amplitudes of its oscillatory components being used to evaluate the effect of the drugs. Because non-drug-specific, current-induced, vasodilation could confound the interpretation of the response, we have investigated the effect of currents of both polarities on the spectral components of the LDF signal in the absence of vasoactive substances. It was recorded for healthy volunteers with both high conductance (5 mol/l NaCl) and low conductance (deionized water) electrolytes. The oscillatory components were analysed by wavelet transform within 0.0095–1.6 Hz, divided into five sub-intervals. Only cathodal iontophoresis with deionized water increased the oscillatory energy and amplitude. It did so at all frequencies, but none of the sub-intervals associated with vasodilation (0.0095–0.145 Hz) was selectively affected compared to the others.
U2 - 10.1088/0031-9155/49/8/N03
DO - 10.1088/0031-9155/49/8/N03
M3 - Journal article
VL - 49
SP - N111-117
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
SN - 1361-6560
IS - 8
ER -