The wetting properties of surfaces, including the adhesion and stiction (static friction) of liquid drops, are critical for processing materials and post-production problems such as fouling. For the novel but very active research field of 2D materials, the interaction of liquids with one- or few-atom-thick matter and its support poses new questions in our understanding of wetting. This paper presents a brief overview of recent research in this area, highlighting differences with materials of other dimensionalities, and remaining issues. © The Electrochemical Society.