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Dynamic glucose-enhanced (DGE)-MRI for non-invasive detection of altered blood-brain barrier glucose transport in dementia

Project: Research


Glucose uptake into the brain is reduced in patients with dementia and it is an important measurement to understand disease mechanisms and monitor progression. Brain imaging with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) provides a gold-standard measurement of glucose uptake but requires invasive arterial blood sampling if quantitation is required. This is a feasibility study to optimise and validate a non-invasive magnetic resonance imaging (MRI) scan, called glucose-enhanced MRI (GE-MRI), to measure glucose uptake by the brain.
Effective start/end date1/11/1831/01/20
  • Emsley, Hedley (Co-Investigator)
  • Parkes, Laura M. (Principal Investigator)
  • Parker, Geoffrey (Co-Investigator)