Stimuli-responsive materials (SRMs) have significant potential for the development of smart biomaterials capable of drug delivery with defined release profiles. We are interested in the design, synthesis, and characterization of biomaterials capable of responding to one or more stimuli, and their use in various paradigms. We employ an interdisciplinary approach combining chemistry (synthesis), materials science and engineering to prepare and characterize SRMs (e.g., mechanics, microscopy and spectroscopy). The SRMs are subsequently exposed to stimuli, and the release profiles of their payloads (e.g., drugs) is quantified (typically spectroscopically). Electricity, light and magnetism are capable of triggering the delivery of drugs or biologics of various molecular weights from these SRMs in vitro and ex vivo. SRMs can deliver a variety of clinically relevant payloads of various molecular weights in response to triggers, and can potentially be used to control the chronopharmacology of their payloads in line with the chronobiology of the condition needing treatment.