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Delivering drugs to tubular cells and organelles: the application of nanodrugs in acute kidney injury - supplementary table

Dataset

  • Zhi Li (Creator)
  • Xiao Fan (Creator)
  • Jialong Fan (Creator)
  • Wei ZhangDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, 410011, China, Peking University, University of Miami, Hunan Agricultural University, Beijing Academy of Agricultural and Forestry Sciences, CAS - Northwest Institute of Eco-Environment and Resources, Tongji University, Changchun University of Chinese Medicine, University of Science and Technology of China, Second Affiliated Hospital of Zhejiang University, National Clinical Research Center for Digestive Diseases, Guangdong Medical College, Chinese Academy of Sciences, Guangdong Provincial Center for Disease Control and Prevention, Shandong Tumor Hospital, University of Chinese Academy of Sciences, Chongqing University of Posts and Telecommunications, Tsinghua University, First Affiliated Hospital of Chongqing Medical University, Bruyère Research Institute, First Affiliated Hospital of Wannan Medical College, Northwest University for Nationalities, Shanghai Sixth People's Hospital, Hebei North University, First Affiliated Hospital of GuangXi Medical University, Jiangsu Academy of Agricultural Sciences, University of British Columbia, Hubei Academy of Agricultural Sciences, Fudan University, Shanghai University of Traditional Chinese Medicine, Guangdong Provincial People's Hospital, Nanjing University, Oregon State University, Capital Medical University, Minzu University of China, Second Military Medical University, Affiliated Hospital of North Sichuan Medical College, University of Electronic Science and Technology of China, Beijing Tian Tan Hospital, Nanjing Agricultural University, First Affiliated Hospital of Nanchang University, Central South University, Southeast University, Shandong University of Finance and Economics, Wenzhou Medical University, Northwestern University, Shanghai Cancer Institute, Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Southern Medical University, First Affiliated Hospital of Soochow University, Zhejiang University, Third Hospital of Hebei Medical University, Shandong University, Centre for Health Evaluation and Outcome Sciences, Huazhong University of Science and Technology, Honghe University, Affiliated Hospital of Xuzhou Medical College, Shaanxi Provincial People's Hospital, Nanjing Tech University, Shanghai Jiao Tong University, Department of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China, Kansas State University, Dian Diagnostics (China), Shandong Provincial Hospital, Nanjing Medical University, Southern University of Science and Technology, Wuhan University, Jiangsu Province Hospital, Xiamen University, Xi'an Medical University, Henan University, Peking University Shenzhen Hospital, Shenzhen University, Chongqing University of Science and Technology, Shanghai Changzheng Hospital, Xuzhou Medical College, Huazhong Agricultural University, First Affiliated Hospital of Zhengzhou University, Hebei Agricultural University, Urology Department Peking University People's Hospital Beijing China, ShenZhen People’s Hospital, Bioprocessing Technology Institute, Umeå University, Chinese Academy of Medical Sciences & Peking Union Medical College, Sun Yat-Sen University, Shandong Academy of Agricultural Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology, Beihang University, Yangtze University, Second Affiliated Hospital of Soochow University, Jinan University, Affiliated Hospital of Zunyi Medical College, Department of Epidemiology, School of Public Health, Air Force Medical University , Xi'an , China, Xinjiang Medical University, Second Affiliated Hospital of Chongqing Medical University, Anhui Academy of Agricultural Sciences, First Affiliated Hospital of Jinan University, Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China, Center for Gene Regulation and Expression, School of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, Scotland, U.K., Xinjiang Agricultural University, Chinese Academy of Agricultural Sciences, Department of Orthopedics, Renmin Hospital, Wuhan University, Wuhan 430060, People's Republic of China., East China Jiaotong University, Dalian Medical University, First Affiliated Hospital of Harbin Medical University, Tianjin Medical University Eye Hospital, Fudan University Shanghai Cancer Center, Heilongjiang Provincial Academy of Agricultural Sciences, Sichuan University, University of Hawaii at Manoa, Henan Provincial People's Hospital, Second Hospital of Hebei Medical University, North West Agriculture and Forestry University, Tianjin University, Hainan University (Creator)
  • Jun Liu (Creator)
  • B. Liu (Creator)
  • Hao ZhangChina agricultural University, Jiangnan University, Pudong Medical Center, Second Affiliated Hospital of Nanjing Medical University, Cornell University, University of Chinese Academy of Sciences, Fudan University, Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Shanghai Stomatological Hospital, Yunnan Academy of Agricultural Sciences, Guangdong University of Petrochemical Technology, Sichuan University, Zhejiang University, Jinan University, Shandong University, Ruijin Hospital, Jiangsu University of Science and Technology, Jilin University, Henan Normal University, Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China, Nanyang Technological University, Chinese Academy of Sciences, Nanjing Agricultural University, Nanjing Medical University, Harvard University, Chongqing Medical University, McGill University, South China University of Technology, Northwestern Polytechnical University Xian, Guangdong Pharmaceutical University, Hunan Agricultural University, Beijing Anzhen Hospital, Yangzhou University, Jiangsu Province Hospital, Shanghai Children's Medical Center, First Affiliated Hospital of Harbin Medical University, Hubei Academy of Agricultural Sciences, Shanghai Jiao Tong University, Zhongnan Hospital of Wuhan University, Chinese Academy of Medical Sciences & Peking Union Medical College, Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Ruian People's Hospital, Department of Pathology, The First Affiliated Hospital of Hainan Medical University, Haikou, China;, Second Affiliated Hospital of Harbin Medical University, Urology Department The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University Qingdao Shandong China, University of Victoria, University of Arizona, Nanchang University, Wenzhou Medical University, Huazhong University of Science and Technology, Ocean University of China, Heilongjiang Provincial Hospital, Dalian University of Technology, Changhai Hospital (Creator)

Description

Acute kidney injury (AKI) is a common clinical syndrome with limited treatment options and high mortality rates. Proximal tubular epithelial cells (PTECs) play a key role in AKI progression. Subcellular dysfunctions, including mitochondrial, nuclear, endoplasmic reticulum and lysosomal dysfunctions, are extensively studied in PTECs. These studies have led to the development of potential therapeutic drugs. However, clinical development of those drugs faces challenges such as low solubility, short circulation time and severe systemic side effects. Nanotechnology provides a promising solution by improving drug properties through nanocrystallization and enabling targeted delivery to specific sites. This review summarizes advancements and limitations of nanoparticle-based drug-delivery systems in targeting PTECs and subcellular organelles, particularly mitochondria, for AKI treatment.
Date made available2023
PublisherFuture Science Group

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