A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule

Barnett, H. Y., Villar, S. S., Geys, H. & Jaki, T., 31/03/2023, In: Biometrics. 79, 1, p. 86-97 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Point estimation for adaptive trial designs I: A methodological review

Robertson, D. S., Choodari‐Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. & Jaki, T., 30/01/2023, In: Statistics in Medicine. 42, 2, p. 122-145 24 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Dose finding studies for therapies with late‐onset toxicities: A comparison study of designs

Barnett, H., Boix, O., Kontos, D. & Jaki, T., 30/12/2022, In: Statistics in Medicine. 41, 30, p. 5767-5788 22 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Practical implementation of the partial ordering continual reassessment method in a Phase I combination‐schedule dose‐finding trial

Mozgunov, P., Jaki, T., Gounaris, I., Goddemeier, T., Victor, A. & Grinberg, M., 30/12/2022, In: Stat. Med.. 41, 30, p. 5789-5809 21 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Proposing a Core Outcome Set for Physical Activity and Exercise Interventions in People With Rare Neurological Conditions

Ramdharry, G., Buscemi, V., Boaz, A., Dawes, H., Jaki, T., Jones, F., Marsden, J., Paul, L., Playle, R., Randell, E., Robling, M., Rochester, L. & Busse, M., 21/10/2021, (E-pub ahead of print) In: Frontiers in Rehabilitation Sciences. 2, 13 p., 705474.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Prior elicitation of the efficacy and tolerability of Methotrexate and Mycophenolate Mofetil in Juvenile Localised Scleroderma

Desai, Y., Jaki, T., Beresford, M. W., Burnett, T., Eleftheriou, D., Jacobe, H., Leone, V., Li, S., Mozgunov, P., Ramanan, A. V., Torok, K. S., Anderson, M. E., Anton, J., Avcin, T., Felton, J., Foeldvari, I., Laguda, B., McErlane, F., Shaw, L. & Zulian, F. & 1 others, Pain, C. E., 9/09/2021, In: AMRC Open Research. 3, p. 20 1 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Study to evaluate the optimal dose of remifentanil required to ensure apnea during magnetic resonance imaging of the heart under general anesthesia

Arnold, P., Sanaulla, S., Hampson, L. V., Davis, A., Tan, J., Cowen, R., Kaleem, M., Williams, A., Wadsworth, I. & Jaki, T., 31/05/2021, In: Paediatric Anesthesia. 31, 5, p. 548-556 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Recurrent events modelling of haemophilia bleeding events

Titman, A., Wolfsegger, M. J. & Jaki, T., 1/03/2021, In: Journal of the Royal Statistical Society: Series C (Applied Statistics). 70, 2, p. 351-371 21 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Exposure–response modelling approaches for determining optimal dosing rules in children

Wadsworth, I., Hampson, L. V., Bornkamp, B. & Jaki, T., 1/09/2020, In: Statistical Methods in Medical Research. 29, 9, p. 2583-2602 20 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Estimation of treatment effects following a sequential trial of multiple treatments

Whitehead, J., Desai, Y. & Jaki, T., 20/05/2020, In: Statistics in Medicine. 39, 11, p. 1593-1609 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A quantitative framework to inform extrapolation decisions in children

Wadsworth, I., Hampson, L. V., Jaki, T., Sills, G. J., Marson, A. G. & Appleton, R., 1/02/2020, In: Journal of the Royal Statistical Society: Series A Statistics in Society. 183, 2, p. 515-534 20 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The R package MAMS for designing multi-arm multi-stage clinical trials

Jaki, T. F., Pallmann, P. S. & Magirr, D., 31/01/2019, In: Journal of Statistical Software. 88, 4, 25 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Model selection based on combined penalties for biomarker identification

Vradi, E., Brannath, W., Jaki, T. & Vonk, R., 4/07/2018, In: Journal of Biopharmaceutical Statistics. 28, 4, p. 735-749 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Extrapolation of efficacy and other data to support the development of new medicines for children: a systematic review of methods

Wadsworth, I., Hampson, L. V. & Jaki, T. F., 1/02/2018, In: Statistical Methods in Medical Research. 27, 2, p. 398-413 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A review of statistical updating methods for clinical prediction models

Su, T.-L., Jaki, T. F., Hickey, G., Buchan, I. & Sperrin, M., 1/01/2018, In: Statistical Methods in Medical Research. 27, 1, p. 185-197 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Identification of Predicted Individual Treatment Effects (PITE) in randomized clinical trials

Lamont, A. E., Lyons, M., Jaki, T. F., Stuart, E. A., Feaster, D., Ishwaran, H., Tharmaratnam, K. & Van Horn, M. L., 1/01/2018, In: Statistical Methods in Medical Research. 27, 1, p. 142-157 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Simultaneous confidence regions for multivariate bioequivalence

Pallmann, P. S. & Jaki, T. F., 20/12/2017, In: Statistics in Medicine. 36, 29, p. 4585-4603 19 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Factorial versus multi-arm multi-stage designs for clinical trials with multiple treatments

Jaki, T. F. & Vasileiou, D., 20/02/2017, In: Statistics in Medicine. 36, 4, p. 563-580 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bayesian survival analysis in clinical trials: what methods are used in practice?

Brard, C., Le Teuff, G., Le Deley, M.-C. & Hampson, L. V., 1/02/2017, In: Clinical Trials. 14, 1, p. 78-87 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

'Threshold crossing': a useful way to establish the counterfactual in clinical trials?

Eichler, H.-G., Bloechl-Daum, B., Bauer, P., Bretz, F., Brown, J., Hampson, L. V., Honig, P., Krams, M., Leufkens, H., Lim, R., Lumpkin, M., Murphy, M., Pignatti, F., Posch, M., Schneeweiss, S., Trusheim, M. & Koenig, F., 12/2016, In: Clinical Pharmacology & Therapeutics. 100, p. 699-712 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Clinical drug development in epilepsy revisited: a proposal for a new paradigm streamlined using extrapolation

Wadsworth, I., Jaki, T. F., Sills, G. J., Appleton, R., Cross, J. H., Marson, A. G., Martland, T., McLellan, A., Smith, P. E. M., Pellock, J. M. & Hampson, L. V., 11/2016, In: CNS Drugs. 30, 11, p. 1011-1017 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A false sense of security? can tiered approach be trusted to accurately classify immunogenicity samples?

Jaki, T. F., Allacher, P. & Horling, F., 5/09/2016, In: Journal of Pharmaceutical and Biomedical Analysis. 128, p. 166-173 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Tilting the lasso by knowledge-based post-processing

Tharmaratnam, K., Sperrin, M., Jaki, T. F., Reppe, S. & Frigessi, A., 2/09/2016, In: BMC Bioinformatics. 17, 9 p., 344.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Understanding clinical prediction models as ‘innovations’: a mixed methods study in UK family practice

Brown, B., Cheraghi-Sohi, S., Jaki, T. F., Su, T.-L., Buchan, I. & Sperrin, M., 9/08/2016, In: BMC Medical Informatics and Decision Making. 16, 13 p., 106.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A comparison of the barely Bayesian design with the triangular test for clinical trials in infectious diseases

Whitehead, J. R., 08/2016, In: Clinical Trials. 13, 4, p. 451-453 3 p.

Research output: Contribution to Journal/Magazine › Letter › peer-review

Why are two mistakes not worse than one? a proposal for controlling the expected number of false claims

Jaki, T. F. & Parry, A., 07/2016, In: Pharmaceutical Statistics. 15, 4, p. 362-367 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A review of statistical designs for improving the efficiency of phase II studies in oncology

Wason, J. & Jaki, T., 06/2016, In: Statistical Methods in Medical Research. 25, 3, p. 1010-1021 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Impact of an equality constraint on the class-specific residual variances in regression mixtures: a Monte Carlo simulation study

Kim, M., Lamont, A. E., Jaki, T., Feaster, D., Howe, G. & Van Horn, M. L., 06/2016, In: Behavior Research Methods. 48, 2, p. 813-826 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Modeling predictors of latent classes in regression mixture models

Kim, M., Vermunt, J., Bakk, Z., Jaki, T. F. & Van Horn, M. L., 06/2016, In: Structural Equation Modeling. 23, 4, p. 601-614 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Experimental treatment of Ebola virus disease with TKM-130803: a single-arm phase 2 clinical trial

RAPIDE-TKM trial team, 19/04/2016, In: PLoS Medicine. 13, 4, 19 p., e1001997.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Designing multi-arm multi-stage clinical trials using a risk-benefit criterion for treatment selection

Jaki, T. & Hampson, L., 20/02/2016, In: Statistics in Medicine. 35, 4, p. 522-533 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Sample size reassessment and hypothesis testing in adaptive survival trials

Magirr, D., Jaki, T. F., Koenig, F. & Posch, M., 10/02/2016, In: PLoS ONE. 11, 2, 14 p., e0146465.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Trial design for evaluating novel treatments during an outbreak of an infectious disease

Whitehead, J. R., Olliaro, P., Lang, T. & Horby, P. W., 02/2016, In: Clinical Trials. 13, 1, p. 31-38 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Using multilevel regression mixture models to identify level-1 heterogeneity in level-2 effects

Van Horn, M. L., Feng, Y., Kim, M., Lamont, A. E., Feaster, D. & Jaki, T., 2016, In: Structural Equation Modeling. 23, 2, p. 259-269 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of Telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy

Pushpakom, S. P., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcıa-Finana, M., Kemp, G. J., Whitehead, J., Jaki, T., Khoo, S., Williamson, P. & Pirmohamed, M., 15/10/2015, In: BMJ Open. 5, 10, 13 p., e009566.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Evaluating differential effects using regression interactions and regression mixture models

Van Horn, M. L., Jaki, T., Maysn, K., Howe, G., Feaster, D., Lamont, A. E., George, M. & Kim, M., 08/2015, In: Educational and Psychological Measurement. 75, 4, p. 677-714 38 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Partial stochastic dominance for the multivariate Gaussian distribution

Turner, A. & Whitehead, J., 08/2015, In: Statistics and Probability Letters. 103, p. 80-85 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Sample size considerations in active-control non-inferiority trials with binary data based on the odds ratio

Siqueira, A. L., Todd, S. & Whitehead, A., 08/2015, In: Statistical Methods in Medical Research. 24, 4, p. 453-461 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data

Cotterill, A., Lorand, D., Wang, J. & Jaki, T., 15/06/2015, In: Statistics in Medicine. 34, 13, p. 2138-2164 27 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Adaptive clinical trials in tuberculosis: applications, challenges and solutions

Davis, G. R., Phillips, P. P. & Jaki, T., 1/06/2015, In: International Journal of Tuberculosis and Lung Disease. 19, 6, p. 626-634 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bayesian sample sizes for exploratory clinical trials comparing multiple experimental treatments with a control

Whitehead, J., Cleary, F. & Turner, A., 30/05/2015, In: Statistics in Medicine. 34, 12, p. 2048-2061 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Multi-arm clinical trials with treatment selection: what can be gained and at what price?

Jaki, T., 04/2015, In: Clinical Investigation. 5, 4, p. 393-399 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa

Beresford, M. W., Bracaglia, C., Caldas, A., Cimaz, R., Dehoorne, J., Dolezalova, P., Friswell, M., Jelusic, M., Marks, S. D., Martin, N., McMahon, A.-M., Peitz, J., van Royen-Kirkhof, A., Soylemezoglu, O., Brogan, P. & MYPAN Vasculitis Expert Group, 30/03/2015, In: PLoS ONE. 10, 3, 14 p., e0120981.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Statistical approaches for the determination of cut points in anti-drug antibody bioassays

Schaarschmidt, F., Hofmann, M., Jaki, T., Gruen, B. & Hothorn, L. A., 03/2015, In: Journal of Immunological Methods. 418, p. 84-100 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Optimising the data combination rule for seamless phase II/III clinical trials

Hampson, L. & Jennison, C., 01/2015, In: Statistics in Medicine. 34, 1, p. 39-58 20 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cholesterol-lowering effects of oat beta-glucan: a meta-analysis of randomized controlled trials

Whitehead, A., Beck, E. J., Tosh, S. & Wolever, T. M. S., 1/12/2014, In: American Journal of Clinical Nutrition. 100, 6, p. 1413-1421 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Mometasone furoate cream reduces acute radiation dermatitis in patients receiving breast radiation therapy: results of a randomized trial

Hindley, A., Zain, Z., Wood, L., Whitehead, A., Sanneh, A., Barber, D. & Hornsby, R., 15/11/2014, In: International Journal of Radiation Oncology - Biology - Physics. 90, 4, p. 748-755 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bayesian methods for the design and interpretation of clinical trials in very rare diseases

Hampson, L., Whitehead, J., Eleftheriou, D. & Brogan, P., 30/10/2014, In: Statistics in Medicine. 33, 24, p. 4186-4201 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bridging the gap: a review of dose investigations in paediatric investigation plans

Hampson, L., Herold, R., Posch, M., Saperia, J. & Whitehead, A., 10/2014, In: British Journal of Clinical Pharmacology. 78, 4, p. 898-907 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Flexible sequential designs for multi-arm clinical trials

Magirr, D., Stallard, N. & Jaki, T., 30/08/2014, In: Statistics in Medicine. 33, 19, p. 3269-3279 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A Bayesian approach to dose finding studies for cancer therapies: incorporating later cycles of therapy

Sinclair, K. & Whitehead, A., 10/07/2014, In: Statistics in Medicine. 33, 15, p. 2665-2680 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest: the randomized CIRC trial

Wik, L., Olsen, J.-A., Persse, D., Sterz, F., Lozano Jr, M., Brouwer, M. A., Westfall, M., Souders, C., Malzer, R., Grunsven, P. M. V., Travis, D., Whitehead, A., Herken, U. R. & Lerner, E. B., 06/2014, In: Resuscitation. 85, 6, p. 741-748 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A comparison of methods for classifying samples as truly specific with confirmatory immunoassays

Jaki, T., Lawo, J.-P., Wolfsegger, M. J., Allacher, P. & Horling, F., 25/01/2014, In: Journal of Pharmaceutical and Biomedical Analysis. 88, p. 27-35 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

Wolfsegger, M. J., Gutjahr, G., Engl, W. & Jaki, T., 2014, In: Biometrics. 70, 1, p. 103-109 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control group: a tutorial

Jaki, T., Kitsche, A. & Hothorn, L. A., 2014, In: JP Journal of Biostatistics. 11, 1, p. 1-32 32 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Authors' reply to comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data settings"

Jaki, T., Pallmann, P. & Wolfsegger, M. J., 30/12/2013, In: Statistics in Medicine. 32, 30, p. 5487-5488 2 p.

Research output: Contribution to Journal/Magazine › Comment/debate

Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs

Jaki, T., Pallmann, P. & Wolfsegger, M. J., 30/12/2013, In: Statistics in Medicine. 32, 30, p. 5469-5483 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A tool to assess the quality of a meta-analysis

Higgins, J. P. T., Lane, P. W., Anagnostelis, B., Anzures-Cabrera, J., Baker, N. F., Cappelleri, J. C., Haughie, S., Hollis, S., Lewis, S. C., Moneuse, P. & Whitehead, A., 12/2013, In: Research Synthesis Methods. 4, 4, p. 351-366 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Exercise and self-management for people with chronic knee, hip or lower back pain: a cluster randomised controlled trial of clinical and cost-effectiveness. Study protocol

Walsh, N., Cramp, F., Palmer, S., Pollock, J., Hampson, L., Gooberman-Hill, R., Green, C., Jones, L., Phillips, S., Johnson, L. & Hurley, M., 12/2013, In: Physiotherapy. 99, 4, p. 352-357 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Methodological quality of meta-analyses: matched-pairs comparison over time and between industry sponsored and academic-sponsored reports

Lane, P. W., Higgins, J. P. T., Anagnostelis, B., Anzures-Cabrera, J., Baker, N. F., Cappelleri, J. C., Haughie, S., Hollis, S., Lewis, S. C., Moneuse, P. & Whitehead, A., 12/2013, In: Research Synthesis Methods. 4, 4, p. 342-350 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Statistical evaluation of toxicological assays: Dunnett or Williams test? − take both

Jaki, T. & Hothorn, L. A., 11/2013, In: Archives of Toxicology. 87, 11, p. 1901-1910 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Mometasone Furoate significantly reduces radiation dermatitis in patients undergoing breast radiation therapy: a double-blind randomized control trial in 120 patients

Dunn, K., Hindley, A., Wood, L., Sanneh, A., Barber, D., Whitehead, A. & Zain, Z., 10/2013, In: International Journal of Radiation Oncology - Biology - Physics. 87, 2 Supplement, p. S115 1 p.

Research output: Contribution to Journal/Magazine › Meeting abstract

Planning multi-arm screening studies within the context of a drug development programme

Wason, J., Jaki, T. & Stallard, N., 10/09/2013, In: Statistics in Medicine. 32, 20, p. 3424-3435 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Differential effects of parental controls on adolescent substance use: for whom is the family most important?

Fagan, A. A., Van Horn, M. L., Hawkins, J. D. & Jaki, T., 09/2013, In: Journal of Quantitative Criminology. 29, 3, p. 347-368 22 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Multiplicity: discussion points from the PSI multiplicity expert group

Phillips, A., Fletcher, C., Atkinson, G., Channon, E., Douiri, A., Jaki, T., Maca, J., Morgan, D., Roger, J. H. & Terrill, P., 09/2013, In: Pharmaceutical Statistics. 12, 5, p. 255-259 5 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Analysing malaria drug trials on a per individual or a per clone basis: a comparison of methods

Jaki, T., Parry, A., Winter, K. & Hastings, I., 30/07/2013, In: Statistics in Medicine. 32, 17, p. 3020-3038 19 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Designing exploratory cancer trials using change in tumour size as primary endpoint

Jaki, T., Andre, V., Su, T.-L. & Whitehead, J., 10/07/2013, In: Statistics in Medicine. 32, 15, p. 2544-2554 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Principles of dose finding studies in cancer: a comparison of trial designs

Jaki, T., Clive, S. & Weir, C., 05/2013, In: Cancer Chemotherapy and Pharmacology. 71, 5, p. 1107-1114 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Uptake of novel statistical methods for early phase clinical studies in the UK public sector

Jaki, T., 04/2013, In: Clinical Trials. 10, 2, p. 344-346 3 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Considerations on covariates and endpoints in multi-arm multi-stage clinical trials selecting all promising treatments

Jaki, T. & Magirr, D., 30/03/2013, In: Statistics in Medicine. 32, 7, p. 1150-1163 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cost-utility analysis conducted alongside randomized controlled trials: Are economic end points considered in sample size calculations and does it matter?

Hollingworth, W., McKell-Redwood, D., Hampson, L. & Metcalfe, C., 02/2013, In: Clinical Trials. 10, 1, p. 43-53 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Group sequential tests for delayed responses

Hampson, L. & Jennison, C., 01/2013, In: Journal of the Royal Statistical Society: Series B (Statistical Methodology). 75, 1, p. 3-54 52 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Finite mixtures for simultaneously modelling differential effects and non-normal distributions

George, M., Yang, N., Jaki, T., Feaster, D., Lamont, A. E., Van Horn, M. L. & Wilson, D. K., 2013, In: Multivariate Behavioral Research. 48, 6, p. 816-844 29 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Using regression mixture models with non-normal data: examining an ordered polytomous approach

George, M., Yang, N., Van Horn, M. L., Smith, J., Jaki, T., Feaster, D., Maysn, K. & Howe, G., 2013, In: Journal of Statistical Computation and Simulation. 83, 4, p. 757-770 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Optimal design of multi-arm multi-stage trials

Wason, J. & Jaki, T., 30/12/2012, In: Statistics in Medicine. 31, 30, p. 4269-4279 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Incorporating prognostic factors into causal estimators: a comparison of methods for RCTs with a time to event outcome

Hampson, L. & Metcalfe, C., 20/11/2012, In: Statistics in Medicine. 31, 26, p. 3073-3088 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A bivariate Bayesian dose-finding procedure applied to a seamless phase I/II trial in rheumatoid arthritis

Thygesen, H., Dragalin, V., Whitehead, A. & Whitehead, J., 11/2012, In: Pharmaceutical Statistics. 11, 6, p. 476-484 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D., 15/08/2012, In: Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Recovering Independent Associations in Genetics: A Comparison

Sperrin, M. & Jaki, T., 08/2012, In: Journal of Computational Biology. 19, 8, p. 978–987 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection

Magirr, D., Jaki, T. & Whitehead, J., 06/2012, In: Biometrika. 99, 2, p. 494-501 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

An international multicentre randomized controlled trial of G17DT in patients with pancreatic cancer

Gilliam, A., Broome, P., Topuzov, E., Garin, A., Pulay, I., Humphreys, J., Whitehead, A., Takhar, A., Rowlands, B. & Beckingham, I., 04/2012, In: Pancreas. 41, 3, p. 374-379 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Investigating the assumption of homogeneity of treatment effects in clincal studies with application to meta-analysis

Julious, S. & Whitehead, A., 01/2012, In: Pharmaceutical Statistics. 11, 1, p. 49-56 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs

Jaki, T. & Wolfsegger, M. J., 2012, In: Statistics in Medicine. 31, 11-12, p. 1059-1073 25 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Not quite normal: Consequences of violating the assumption of normality with regression mixture models

Van Horn, M. L., Smith, J., Fagan, A., Jaki, T., Maysn, K., Hawkins, D., Feaster, D. & Howe, G., 2012, In: Structural Equation Modeling. 19, 2, p. 227-249 23 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Spatial and temporal patterns in antimicrobial resistance of Salmonella Typhimurium amongst cattle in England and Wales

Cox, R., Su, T.-L., Clough, H., Woodward, M. & Sherlock, C., 2012, In: Epidemiology and Infection. p. 1-12 12 p., PMID: 22214772.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bayesian procedures for phase I/II clinical trials investigating the safety and efficacy of drug combinations

Whitehead, J., Thygesen, H. & Whitehead, A., 20/07/2011, In: Statistics in Medicine. 30, 16, p. 1952-1970 19 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A formal comparison of different methods for establishing cut points to distinguish positive and negative samples in immunoassays.

Jaki, T., Lawo, J.-P., Wolfsegger, M. J., Singer, J., Allacher, P. & Horling, F., 15/07/2011, In: Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1148-1156 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Block response-adaptive randomization in clinical trials with binary endpoints

Magirr, D., 07/2011, In: Pharmaceutical Statistics. 10, 4, p. 341-346 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Estimation of pharmacokinetic parameters with the R package PK.

Jaki, T. & Wolfsegger, M. J., 05/2011, In: Pharmaceutical Statistics. 10, 2, p. 284-288 5 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Sequential methods for random-effects meta-analysis

Higgins, J. P. T., Whitehead, A. & Simmonds, M., 30/04/2011, In: Statistics in Medicine. 30, 9, p. 903-921 19 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Design of the circulation improving resuscitation care (CIRC) trial: a new state of the art design for out-of-hospital cardiac arrest research

Lerner, E. B., Persse, D., Souders, C., Sterz, F., Malzer, R., Lozano, M., Westfall, M., Brouwer, M. A., Grunsven, P. M. V., Whitehead, A., Olsen, J.-A., Herken, U. R. & Wik, L., 03/2011, In: Resuscitation. 82, 3, p. 294-299 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Symmetric maximum kernel likelihood estimation.

Jaki, T. & West, R. W., 02/2011, In: Journal of Statistical Computation and Simulation. 81, 2, p. 193-206 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Direct effects testing : a two-stage procedure to test for effect size and variable importance for correlated binary predictors and a binary response.

Sperrin, M. & Jaki, T., 30/10/2010, In: Statistics in Medicine. 29, 24, p. 2544-2556 13 p.

Research output: Contribution to Journal/Magazine › Journal article

A Bayesian dose-escalation procedure for phase I clinical trials based only on the assumption of monotonicity.

Whitehead, J., Thygesen, H. & Whitehead, A., 30/07/2010, In: Statistics in Medicine. 29, 17, p. 1808-1824 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Establishing bioequivalence in complete and incomplete data designs using AUCs.

Jaki, T., Wolfsegger, M. J. & Lawo, J.-P., 07/2010, In: Journal of Biopharmaceutical Statistics. 20, 4, p. 803-820 18 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Optimization, refinement and reduction of murine in vivo experiments to assess therapeutic approaches for hemophilia A.

Baumgartner, B., Jaki, T., Wolfsegger, M. J., Eder, B., Schiviz, A., Schwarz, H. P. & Muchitsch, E. M., 07/2010, In: Laboratory Animals. 44, 3, p. 211-217 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Probabilistic relabelling strategies for the label switching problem in Bayesian mixture models.

Sperrin, M., Jaki, T. & Wit, E., 07/2010, In: Statistics and Computing. 20, 3, p. 357-366 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review