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Medical and Pharmaceutical Statistics Research Unit

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  1. Published

    Extrapolation of efficacy and other data to support the development of new medicines for children: a systematic review of methods

    Wadsworth, I., Hampson, L. V. & Jaki, T. F., 1/02/2018, In: Statistical Methods in Medical Research. 27, 2, p. 398-413 16 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    Clinical drug development in epilepsy revisited: a proposal for a new paradigm streamlined using extrapolation

    Wadsworth, I., Jaki, T. F., Sills, G. J., Appleton, R., Cross, J. H., Marson, A. G., Martland, T., McLellan, A., Smith, P. E. M., Pellock, J. M. & Hampson, L. V., 11/2016, In: CNS Drugs. 30, 11, p. 1011-1017 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    A quantitative framework to inform extrapolation decisions in children

    Wadsworth, I., Hampson, L. V., Jaki, T., Sills, G. J., Marson, A. G. & Appleton, R., 1/02/2020, In: Journal of the Royal Statistical Society: Series A Statistics in Society. 183, 2, p. 515-534 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Exposure–response modelling approaches for determining optimal dosing rules in children

    Wadsworth, I., Hampson, L. V., Bornkamp, B. & Jaki, T., 1/09/2020, In: Statistical Methods in Medical Research. 29, 9, p. 2583-2602 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Exercise and self-management for people with chronic knee, hip or lower back pain: a cluster randomised controlled trial of clinical and cost-effectiveness. Study protocol

    Walsh, N., Cramp, F., Palmer, S., Pollock, J., Hampson, L., Gooberman-Hill, R., Green, C., Jones, L., Phillips, S., Johnson, L. & Hurley, M., 12/2013, In: Physiotherapy. 99, 4, p. 352-357 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Optimal design of multi-arm multi-stage trials

    Wason, J. & Jaki, T., 30/12/2012, In: Statistics in Medicine. 31, 30, p. 4269-4279 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Planning multi-arm screening studies within the context of a drug development programme

    Wason, J., Jaki, T. & Stallard, N., 10/09/2013, In: Statistics in Medicine. 32, 20, p. 3424-3435 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    A review of statistical designs for improving the efficiency of phase II studies in oncology

    Wason, J. & Jaki, T., 06/2016, In: Statistical Methods in Medical Research. 25, 3, p. 1010-1021 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Sequential genome-wide association studies for monitoring adverse events in clinical evaluation of new drugs.

    Whitehead, J., Kelly, P. J., Stallard, N., Zhou, Y. & Bowman, C., 30/09/2006, In: Statistics in Medicine. 25, 18, p. 3081-3092 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Implementation of a Bayesian design in a dose-escalation study of an experimental agent in healthy volunteers.

    Whitehead, J., Korhonen, P., Mustonen, M. & Zhou, Y., 03/2008, In: Biometrics. 64, 1, p. 299-308 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.

    Whitehead, J. & Jaki, T., 28/02/2009, In: Statistics in Medicine. 28, 5, p. 828-847 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    A simple two-stage design for quantitative responses with appliction to a study in diabectic neuropathic pain.

    Whitehead, J., Valdés-Márquez, E. & Lissmats, A., 04/2009, In: Pharmaceutical Statistics. 8, 2, p. 125-135 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Using historical lesion volume data in the design of a new phase II clinical trial in acute stroke.

    Whitehead, J., Bolland, K., Valdés-Márquez, E., Lihic, A., Ali, M. & Lees, K., 04/2009, In: Stroke. 40, 4, p. 1347-1352 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    A combined score test for binary and ordinal endpoints from clinical trials.

    Whitehead, J., Branson, M. & Todd, S., 28/02/2010, In: Statistics in Medicine. 29, 5, p. 521-532 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme.

    Whitehead, J., Kelly, P., Zhou, Y., Stallard, N., Thygesen, H. & Bowman, C., 10/2009, In: Pharmaceutical Statistics. 8, 4, p. 287-300 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Fitting models for the joint action of two drugs using SAS(R).

    Whitehead, A., Whitehead, J., Todd, S., Zhou, Y. & Smith, M. K., 10/2008, In: Pharmaceutical Statistics. 7, 4, p. 272-284 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Incorporating intermediate binary responses into interim analyses of clinical trials : a comparison of four methods.

    Whitehead, A., Sooriyarachchi, M. R., Whitehead, J. & Bolland, K., 10/05/2008, In: Statistics in Medicine. 27, 10, p. 1646-1666 21 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    A Bayesian approach for dose-escalation in a phase I clinical trial incorporating pharmacodynamic endpoints .

    Whitehead, J., Hampson, L., Zhou, Y., Ledent, E. & Pereira, A., 11/2007, In: Journal of Biopharmaceutical Statistics. 17, 6, p. 1117-1129 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Bayesian procedures for phase I/II clinical trials investigating the safety and efficacy of drug combinations

    Whitehead, J., Thygesen, H. & Whitehead, A., 20/07/2011, In: Statistics in Medicine. 30, 16, p. 1952-1970 19 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    A Bayesian dose-escalation procedure for phase I clinical trials based only on the assumption of monotonicity.

    Whitehead, J., Thygesen, H. & Whitehead, A., 30/07/2010, In: Statistics in Medicine. 29, 17, p. 1808-1824 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Bayesian sample size for exploratory clinical trials incorporating historical data.

    Whitehead, J., Valdés-Márquez, E., Johnson, P. & Graham, G., 06/2008, In: Statistics in Medicine. 27, 13, p. 2307-2327 21 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

    Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D., 15/08/2012, In: Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Bayesian sample sizes for exploratory clinical trials comparing multiple experimental treatments with a control

    Whitehead, J., Cleary, F. & Turner, A., 30/05/2015, In: Statistics in Medicine. 34, 12, p. 2048-2061 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Cholesterol-lowering effects of oat beta-glucan: a meta-analysis of randomized controlled trials

    Whitehead, A., Beck, E. J., Tosh, S. & Wolever, T. M. S., 1/12/2014, In: American Journal of Clinical Nutrition. 100, 6, p. 1413-1421 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    A comparison of the barely Bayesian design with the triangular test for clinical trials in infectious diseases

    Whitehead, J. R., 08/2016, In: Clinical Trials. 13, 4, p. 451-453 3 p.

    Research output: Contribution to Journal/Magazine › Letter › peer-review

  26. Published

    Trial design for evaluating novel treatments during an outbreak of an infectious disease

    Whitehead, J. R., Olliaro, P., Lang, T. & Horby, P. W., 02/2016, In: Clinical Trials. 13, 1, p. 31-38 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. Published

    Estimation of treatment effects following a sequential trial of multiple treatments

    Whitehead, J., Desai, Y. & Jaki, T., 20/05/2020, In: Statistics in Medicine. 39, 11, p. 1593-1609 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. Published

    Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest: the randomized CIRC trial

    Wik, L., Olsen, J-A., Persse, D., Sterz, F., Lozano Jr, M., Brouwer, M. A., Westfall, M., Souders, C., Malzer, R., Grunsven, P. M. V., Travis, D., Whitehead, A., Herken, U. R. & Lerner, E. B., 06/2014, In: Resuscitation. 85, 6, p. 741-748 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  29. Published

    A note on statistical analysis of organ weights in non-clinical toxicological studies.

    Wolfsegger, M. J., Jaki, T., Dietrich, B., Kunzler, J. A. & Barker, K., 10/2009, In: Toxicology and Applied Pharmacology. 240, 1, p. 117-122 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  30. Published

    Non-compartmental estimation of pharmacokinetic parameters in serial sampling designs.

    Wolfsegger, M. J. & Jaki, T., 10/2009, In: Journal of Pharmacokinetics and Pharmacodynamics. 36, 5, p. 479-494

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. Published

    Assessing systemic drug exposure in repeated dose toxicity studies in the case of complete and incomplete sampling.

    Wolfsegger, M. J. & Jaki, T., 12/2009, In: Biometrical Journal. 51, 6, p. 1017-1026 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  32. Published

    Simultaneous confidence intervals by iteratively adjusted alpha for relative effects in the one-way layout.

    Wolfsegger, M. J. & Jaki, T., 2006, In: Statistics and Computing. 16, 1, p. 15-23 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. Published

    A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

    Wolfsegger, M. J., Gutjahr, G., Engl, W. & Jaki, T., 2014, In: Biometrics. 70, 1, p. 103-109 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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