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Medical and Pharmaceutical Statistics Research Unit

  1. 2006
  2. Published

    Simultaneous confidence intervals by iteratively adjusted alpha for relative effects in the one-way layout.

    Wolfsegger, M. J. & Jaki, T., 2006, In: Statistics and Computing. 16, 1, p. 15-23 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    The sequential analysis of repeated binary responses: a score test for the case of three time points.

    Sooriyarachchi, M. R., Whitehead, J., Whitehead, A. & Bolland, K., 15/07/2006, In: Statistics in Medicine. 25, 13, p. 2196-2214 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Sequential genome-wide association studies for monitoring adverse events in clinical evaluation of new drugs.

    Whitehead, J., Kelly, P. J., Stallard, N., Zhou, Y. & Bowman, C., 30/09/2006, In: Statistics in Medicine. 25, 18, p. 3081-3092 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. 2007
  6. Published

    Strategies to prevent falls and fractures in hospitals and care homes and effect of cognitive impairment: systematic review and meta- analysis.

    Oliver, D., Connelly, J. B., Victor, C. R. & Whitehead, A., 13/01/2007, In: BMJ. 334, 7584, p. 82-85 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial.

    The Working Group on Selective Decontamination of the Digestive Tract, 02/2007, In: Intensive Care Medicine. 33, 2, p. 261-270 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    A Bayesian approach for dose-escalation in a phase I clinical trial incorporating pharmacodynamic endpoints .

    Whitehead, J., Hampson, L., Zhou, Y., Ledent, E. & Pereira, A., 11/2007, In: Journal of Biopharmaceutical Statistics. 17, 6, p. 1117-1129 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  9. 2008
  10. Published

    Book review: Applied Nonparametric Statistical Methods.

    Jaki, T., 2008, In: Journal of Biopharmaceutical Statistics. 18, 2, p. 393-395 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Maximum kernel likelihood estimation

    Jaki, T. & West, R. W., 2008, In: Journal of Computational and Graphical Statistics. 17, 4, p. 976-993 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Active-control trials with binary data: a comparison of methods for testing superiority or non-inferiority using the odds ratio.

    Siqueira, A., Whitehead, A. & Todd, S., 10/02/2008, In: Statistics in Medicine. 27, 3, p. 353-370 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Implementation of a Bayesian design in a dose-escalation study of an experimental agent in healthy volunteers.

    Whitehead, J., Korhonen, P., Mustonen, M. & Zhou, Y., 03/2008, In: Biometrics. 64, 1, p. 299-308 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Using Multilevel Mixtures to Evaluate Intervention Effects in Group Randomized Trials.

    Van Horn, M. L., Fagan, A. A., Jaki, T., Brown, E. C., Hawkins, J. D., Arthur, M. W., Abbott, R. D. & Catalano, R. F., 04/2008, In: Multivariate Behavioral Research. 43, 2, p. 289-326 38 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Incorporating intermediate binary responses into interim analyses of clinical trials : a comparison of four methods.

    Whitehead, A., Sooriyarachchi, M. R., Whitehead, J. & Bolland, K., 10/05/2008, In: Statistics in Medicine. 27, 10, p. 1646-1666 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Sequentially testing for a gene-drug interaction in a genomewide analysis.

    Kelly, P., Zhou, Y., Whitehead, J., Stallard, N. & Bowman, C., 20/05/2008, In: Statistics in Medicine. 27, 11, p. 2022-2034 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Bayesian sample size for exploratory clinical trials incorporating historical data.

    Whitehead, J., Valdés-Márquez, E., Johnson, P. & Graham, G., 06/2008, In: Statistics in Medicine. 27, 13, p. 2307-2327 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    A safety monitoring procesure for a clinical drug development programme, with application to the accessment of a novel COX-2 inhibitor.

    Bolland, K., Whitehead, J. & Oldham, M., 07/2008, In: Journal of Biopharmaceutical Statistics. 18, 4, p. 737-749 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Estimation following selection of the largest of two normal means. Journal of Statistical Planning and Inference 138, 1629-1638.

    Stallard, N., Todd, S. & Whitehead, J., 1/07/2008, In: Journal of Statistical Planning and Inference. 138, 6, p. 1629-1638 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Fitting models for the joint action of two drugs using SAS(R).

    Whitehead, A., Whitehead, J., Todd, S., Zhou, Y. & Smith, M. K., 10/2008, In: Pharmaceutical Statistics. 7, 4, p. 272-284 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. 2009
  22. Published

    Confidence Intervals for Ratios of AUC's in the Case of Serial Sampling : A Comparison of Seven Methods.

    Jaki, T., Wolfsegger, M. J. & Ploner, M., 01/2009, In: Pharmaceutical Statistics. 8, 1, p. 12-24 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Meta-analysis of individual patient data versus aggregate data from longitudinal clinical trials.

    Jones, A., Riley, R., Williamson, P. & Whitehead, A., 02/2009, In: Clinical Trials. 6, 1, p. 16-27 12 p.

    Research output: Contribution to journalJournal article

  24. Published

    One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.

    Whitehead, J. & Jaki, T., 28/02/2009, In: Statistics in Medicine. 28, 5, p. 828-847 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    A simple two-stage design for quantitative responses with appliction to a study in diabectic neuropathic pain.

    Whitehead, J., Valdés-Márquez, E. & Lissmats, A., 04/2009, In: Pharmaceutical Statistics. 8, 2, p. 125-135 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline.

    Bolland, K., Whitehead, J., Cobo, E. & Secades, J. J., 04/2009, In: Pharmaceutical Statistics. 8, 2, p. 136-149 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Using historical lesion volume data in the design of a new phase II clinical trial in acute stroke.

    Whitehead, J., Bolland, K., Valdés-Márquez, E., Lihic, A., Ali, M. & Lees, K., 04/2009, In: Stroke. 40, 4, p. 1347-1352 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    A theoretical framework for estimation of AUCs in complete and incomplete sampling designs.

    Jaki, T. & Wolfsegger, M. J., 05/2009, In: Statistics in Biopharmaceutical Research. 1, 2, p. 176-184 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Using a problem-based approach to teach statistics to postgraduate science students : a case study.

    Jaki, T. & Autin, M., 05/2009, In: MSOR Connections. 9, 2, p. 40-47 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Assessing differential effects: Applying regression mixture models to identify variations in the influence of family resources on academic achievement.

    Van Horn, M. L., Jaki, T., Maysn, K., Ramey, S. L., Smith, J. A. & Antaramian, S., 09/2009, In: Developmental Psychology. 45, 5, p. 1298-1313 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    A note on statistical analysis of organ weights in non-clinical toxicological studies.

    Wolfsegger, M. J., Jaki, T., Dietrich, B., Kunzler, J. A. & Barker, K., 10/2009, In: Toxicology and Applied Pharmacology. 240, 1, p. 117-122 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme.

    Whitehead, J., Kelly, P., Zhou, Y., Stallard, N., Thygesen, H. & Bowman, C., 10/2009, In: Pharmaceutical Statistics. 8, 4, p. 287-300 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Non-compartmental estimation of pharmacokinetic parameters in serial sampling designs.

    Wolfsegger, M. J. & Jaki, T., 10/2009, In: Journal of Pharmacokinetics and Pharmacodynamics. 36, 5, p. 479-494

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Recording lectures as a service in a service course.

    Jaki, T., 11/2009, In: Journal of Statistics Education. 17, 3

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Assessing systemic drug exposure in repeated dose toxicity studies in the case of complete and incomplete sampling.

    Wolfsegger, M. J. & Jaki, T., 12/2009, In: Biometrical Journal. 51, 6, p. 1017-1026 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. 2010
  37. Published

    A combined score test for binary and ordinal endpoints from clinical trials.

    Whitehead, J., Branson, M. & Todd, S., 28/02/2010, In: Statistics in Medicine. 29, 5, p. 521-532 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    Geostatistical inference under preferential sampling

    Diggle, P. J., Menezes, R. & Su, T., 03/2010, In: Journal of the Royal Statistical Society: Series C (Applied Statistics). 59, 2, p. 191-232 42 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Book review : Bioequivalence and statistics in clinical pharmacology.

    Jaki, T., 04/2010, In: Journal of the Royal Statistical Society: Series A Statistics in Society. 173, 2, p. 467-468 2 p.

    Research output: Contribution to journalBook/Film/Article review

  40. Published

    Establishing bioequivalence in complete and incomplete data designs using AUCs.

    Jaki, T., Wolfsegger, M. J. & Lawo, J-P., 07/2010, In: Journal of Biopharmaceutical Statistics. 20, 4, p. 803-820 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Optimization, refinement and reduction of murine in vivo experiments to assess therapeutic approaches for hemophilia A.

    Baumgartner, B., Jaki, T., Wolfsegger, M. J., Eder, B., Schiviz, A., Schwarz, H. P. & Muchitsch, E. M., 07/2010, In: Laboratory Animals. 44, 3, p. 211-217 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Probabilistic relabelling strategies for the label switching problem in Bayesian mixture models.

    Sperrin, M., Jaki, T. & Wit, E., 07/2010, In: Statistics and Computing. 20, 3, p. 357-366 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    A Bayesian dose-escalation procedure for phase I clinical trials based only on the assumption of monotonicity.

    Whitehead, J., Thygesen, H. & Whitehead, A., 30/07/2010, In: Statistics in Medicine. 29, 17, p. 1808-1824 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Direct effects testing : a two-stage procedure to test for effect size and variable importance for correlated binary predictors and a binary response.

    Sperrin, M. & Jaki, T., 30/10/2010, In: Statistics in Medicine. 29, 24, p. 2544-2556 13 p.

    Research output: Contribution to journalJournal article

  45. 2011
  46. Published

    Symmetric maximum kernel likelihood estimation.

    Jaki, T. & West, R. W., 02/2011, In: Journal of Statistical Computation and Simulation. 81, 2, p. 193-206 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Design of the circulation improving resuscitation care (CIRC) trial: a new state of the art design for out-of-hospital cardiac arrest research

    Lerner, E. B., Persse, D., Souders, C., Sterz, F., Malzer, R., Lozano, M., Westfall, M., Brouwer, M. A., Grunsven, P. M. V., Whitehead, A., Olsen, J-A., Herken, U. R. & Wik, L., 03/2011, In: Resuscitation. 82, 3, p. 294-299 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Sequential methods for random-effects meta-analysis

    Higgins, J. P. T., Whitehead, A. & Simmonds, M., 30/04/2011, In: Statistics in Medicine. 30, 9, p. 903-921 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Estimation of pharmacokinetic parameters with the R package PK.

    Jaki, T. & Wolfsegger, M. J., 05/2011, In: Pharmaceutical Statistics. 10, 2, p. 284-288 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Block response-adaptive randomization in clinical trials with binary endpoints

    Magirr, D., 07/2011, In: Pharmaceutical Statistics. 10, 4, p. 341-346 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    A formal comparison of different methods for establishing cut points to distinguish positive and negative samples in immunoassays.

    Jaki, T., Lawo, J-P., Wolfsegger, M. J., Singer, J., Allacher, P. & Horling, F., 15/07/2011, In: Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1148-1156 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    Bayesian procedures for phase I/II clinical trials investigating the safety and efficacy of drug combinations

    Whitehead, J., Thygesen, H. & Whitehead, A., 20/07/2011, In: Statistics in Medicine. 30, 16, p. 1952-1970 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  53. 2012
  54. Published

    Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs

    Jaki, T. & Wolfsegger, M. J., 2012, In: Statistics in Medicine. 31, 11-12, p. 1059-1073 25 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Not quite normal: Consequences of violating the assumption of normality with regression mixture models

    Van Horn, M. L., Smith, J., Fagan, A., Jaki, T., Maysn, K., Hawkins, D., Feaster, D. & Howe, G., 2012, In: Structural Equation Modeling. 19, 2, p. 227-249 23 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    Spatial and temporal patterns in antimicrobial resistance of Salmonella Typhimurium amongst cattle in England and Wales

    Cox, R., Su, T-L., Clough, H., Woodward, MJ. & Sherlock, C., 2012, In: Epidemiology and Infection. p. 1-12 12 p., PMID: 22214772.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    Investigating the assumption of homogeneity of treatment effects in clincal studies with application to meta-analysis

    Julious, S. & Whitehead, A., 01/2012, In: Pharmaceutical Statistics. 11, 1, p. 49-56 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  58. Published

    An international multicentre randomized controlled trial of G17DT in patients with pancreatic cancer

    Gilliam, A., Broome, P., Topuzov, E., Garin, A., Pulay, I., Humphreys, J., Whitehead, A., Takhar, A., Rowlands, B. & Beckingham, I., 04/2012, In: Pancreas. 41, 3, p. 374-379 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  59. Published

    A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection

    Magirr, D., Jaki, T. & Whitehead, J., 06/2012, In: Biometrika. 99, 2, p. 494-501 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  60. Published

    Recovering Independent Associations in Genetics: A Comparison

    Sperrin, M. & Jaki, T., 08/2012, In: Journal of Computational Biology. 19, 8, p. 978–987 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  61. Published

    A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

    Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D., 15/08/2012, In: Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. Published

    C Code to design error spending tests for delayed responses

    Hampson, L. & Jennison, C., 3/09/2012

    Research output: Exhibits, objects and web-based outputsSoftware

  63. Published

    A bivariate Bayesian dose-finding procedure applied to a seamless phase I/II trial in rheumatoid arthritis

    Thygesen, H., Dragalin, V., Whitehead, A. & Whitehead, J., 11/2012, In: Pharmaceutical Statistics. 11, 6, p. 476-484 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  64. Published

    Incorporating prognostic factors into causal estimators: a comparison of methods for RCTs with a time to event outcome

    Hampson, L. & Metcalfe, C., 20/11/2012, In: Statistics in Medicine. 31, 26, p. 3073-3088 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  65. Published

    Optimal design of multi-arm multi-stage trials

    Wason, J. & Jaki, T., 30/12/2012, In: Statistics in Medicine. 31, 30, p. 4269-4279 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  66. 2013
  67. Published

    Finite mixtures for simultaneously modelling differential effects and non-normal distributions

    George, M., Yang, N., Jaki, T., Feaster, D., Lamont, A. E., Van Horn, M. L. & Wilson, D. K., 2013, In: Multivariate Behavioral Research. 48, 6, p. 816-844 29 p.

    Research output: Contribution to journalJournal articlepeer-review

  68. Published

    Using regression mixture models with non-normal data: examining an ordered polytomous approach

    George, M., Yang, N., Van Horn, M. L., Smith, J., Jaki, T., Feaster, D., Maysn, K. & Howe, G., 2013, In: Journal of Statistical Computation and Simulation. 83, 4, p. 757-770 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  69. Published

    Group sequential tests for delayed responses

    Hampson, L. & Jennison, C., 01/2013, In: Journal of the Royal Statistical Society: Series B (Statistical Methodology). 75, 1, p. 3-54 52 p.

    Research output: Contribution to journalJournal articlepeer-review

  70. Published

    Cost-utility analysis conducted alongside randomized controlled trials: Are economic end points considered in sample size calculations and does it matter?

    Hollingworth, W., McKell-Redwood, D., Hampson, L. & Metcalfe, C., 02/2013, In: Clinical Trials. 10, 1, p. 43-53 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  71. Published

    Considerations on covariates and endpoints in multi-arm multi-stage clinical trials selecting all promising treatments

    Jaki, T. & Magirr, D., 30/03/2013, In: Statistics in Medicine. 32, 7, p. 1150-1163 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  72. Published

    Uptake of novel statistical methods for early phase clinical studies in the UK public sector

    Jaki, T., 04/2013, In: Clinical Trials. 10, 2, p. 344-346 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  73. Published

    Principles of dose finding studies in cancer: a comparison of trial designs

    Jaki, T., Clive, S. & Weir, C., 05/2013, In: Cancer Chemotherapy and Pharmacology. 71, 5, p. 1107-1114 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  74. Published

    Designing exploratory cancer trials using change in tumour size as primary endpoint

    Jaki, T., Andre, V., Su, T-L. & Whitehead, J., 10/07/2013, In: Statistics in Medicine. 32, 15, p. 2544-2554 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  75. Published

    Analysing malaria drug trials on a per individual or a per clone basis: a comparison of methods

    Jaki, T., Parry, A., Winter, K. & Hastings, I., 30/07/2013, In: Statistics in Medicine. 32, 17, p. 3020-3038 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  76. Published

    Differential effects of parental controls on adolescent substance use: for whom is the family most important?

    Fagan, A. A., Van Horn, M. L., Hawkins, J. D. & Jaki, T., 09/2013, In: Journal of Quantitative Criminology. 29, 3, p. 347-368 22 p.

    Research output: Contribution to journalJournal articlepeer-review

  77. Published

    Multiplicity: discussion points from the PSI multiplicity expert group

    Phillips, A., Fletcher, C., Atkinson, G., Channon, E., Douiri, A., Jaki, T., Maca, J., Morgan, D., Roger, J. H. & Terrill, P., 09/2013, In: Pharmaceutical Statistics. 12, 5, p. 255-259 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  78. Published

    Planning multi-arm screening studies within the context of a drug development programme

    Wason, J., Jaki, T. & Stallard, N., 10/09/2013, In: Statistics in Medicine. 32, 20, p. 3424-3435 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  79. Published

    Mometasone Furoate significantly reduces radiation dermatitis in patients undergoing breast radiation therapy: a double-blind randomized control trial in 120 patients

    Dunn, K., Hindley, A., Wood, L., Sanneh, A., Barber, D., Whitehead, A. & Zain, Z., 10/2013, In: International Journal of Radiation Oncology - Biology - Physics. 87, 2 Supplement, p. S115 1 p.

    Research output: Contribution to journalMeeting abstract

  80. Published

    Statistical evaluation of toxicological assays: Dunnett or Williams test? − take both

    Jaki, T. & Hothorn, L. A., 11/2013, In: Archives of Toxicology. 87, 11, p. 1901-1910 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  81. Published

    A tool to assess the quality of a meta-analysis

    Higgins, J. P. T., Lane, P. W., Anagnostelis, B., Anzures-Cabrera, J., Baker, N. F., Cappelleri, J. C., Haughie, S., Hollis, S., Lewis, S. C., Moneuse, P. & Whitehead, A., 12/2013, In: Research Synthesis Methods. 4, 4, p. 351-366 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  82. Published

    Exercise and self-management for people with chronic knee, hip or lower back pain: a cluster randomised controlled trial of clinical and cost-effectiveness. Study protocol

    Walsh, N., Cramp, F., Palmer, S., Pollock, J., Hampson, L., Gooberman-Hill, R., Green, C., Jones, L., Phillips, S., Johnson, L. & Hurley, M., 12/2013, In: Physiotherapy. 99, 4, p. 352-357 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  83. Published

    Methodological quality of meta-analyses: matched-pairs comparison over time and between industry sponsored and academic-sponsored reports

    Lane, P. W., Higgins, J. P. T., Anagnostelis, B., Anzures-Cabrera, J., Baker, N. F., Cappelleri, J. C., Haughie, S., Hollis, S., Lewis, S. C., Moneuse, P. & Whitehead, A., 12/2013, In: Research Synthesis Methods. 4, 4, p. 342-350 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  84. Published

    Authors' reply to comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data settings"

    Jaki, T., Pallmann, P. & Wolfsegger, M. J., 30/12/2013, In: Statistics in Medicine. 32, 30, p. 5487-5488 2 p.

    Research output: Contribution to journalComment/debate

  85. Published

    Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs

    Jaki, T., Pallmann, P. & Wolfsegger, M. J., 30/12/2013, In: Statistics in Medicine. 32, 30, p. 5469-5483 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  86. 2014
  87. Published

    A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

    Wolfsegger, M. J., Gutjahr, G., Engl, W. & Jaki, T., 2014, In: Biometrics. 70, 1, p. 103-109 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  88. Published

    Designing multi-arm multi-stage clinical studies

    Jaki, T., 2014, Developments in statistical evaluation of clinical trials. van Montfort, K., Oud, J. & Ghidey, W. (eds.). Berlin: Springer, p. 51-69 19 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter (peer-reviewed)peer-review

  89. Published
  90. Published

    Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control group: a tutorial

    Jaki, T., Kitsche, A. & Hothorn, L. A., 2014, In: JP Journal of Biostatistics. 11, 1, p. 1-32 32 p.

    Research output: Contribution to journalJournal articlepeer-review

  91. Published

    A comparison of methods for classifying samples as truly specific with confirmatory immunoassays

    Jaki, T., Lawo, J-P., Wolfsegger, M. J., Allacher, P. & Horling, F., 25/01/2014, In: Journal of Pharmaceutical and Biomedical Analysis. 88, p. 27-35 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  92. Published

    Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest: the randomized CIRC trial

    Wik, L., Olsen, J-A., Persse, D., Sterz, F., Lozano Jr, M., Brouwer, M. A., Westfall, M., Souders, C., Malzer, R., Grunsven, P. M. V., Travis, D., Whitehead, A., Herken, U. R. & Lerner, E. B., 06/2014, In: Resuscitation. 85, 6, p. 741-748 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  93. Published

    A Bayesian approach to dose finding studies for cancer therapies: incorporating later cycles of therapy

    Sinclair, K. & Whitehead, A., 10/07/2014, In: Statistics in Medicine. 33, 15, p. 2665-2680 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  94. Published

    Flexible sequential designs for multi-arm clinical trials

    Magirr, D., Stallard, N. & Jaki, T., 30/08/2014, In: Statistics in Medicine. 33, 19, p. 3269-3279 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  95. Published

    Bridging the gap: a review of dose investigations in paediatric investigation plans

    Hampson, L., Herold, R., Posch, M., Saperia, J. & Whitehead, A., 10/2014, In: British Journal of Clinical Pharmacology. 78, 4, p. 898-907 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  96. Published

    Bayesian methods for the design and interpretation of clinical trials in very rare diseases

    Hampson, L., Whitehead, J., Eleftheriou, D. & Brogan, P., 30/10/2014, In: Statistics in Medicine. 33, 24, p. 4186-4201 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  97. Published

    Mometasone furoate cream reduces acute radiation dermatitis in patients receiving breast radiation therapy: results of a randomized trial

    Hindley, A., Zain, Z., Wood, L., Whitehead, A., Sanneh, A., Barber, D. & Hornsby, R., 15/11/2014, In: International Journal of Radiation Oncology - Biology - Physics. 90, 4, p. 748-755 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  98. Published

    Cholesterol-lowering effects of oat beta-glucan: a meta-analysis of randomized controlled trials

    Whitehead, A., Beck, E. J., Tosh, S. & Wolever, T. M. S., 1/12/2014, In: American Journal of Clinical Nutrition. 100, 6, p. 1413-1421 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  99. 2015
  100. Published

    Optimising the data combination rule for seamless phase II/III clinical trials

    Hampson, L. & Jennison, C., 01/2015, In: Statistics in Medicine. 34, 1, p. 39-58 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  101. Published

    Statistical approaches for the determination of cut points in anti-drug antibody bioassays

    Schaarschmidt, F., Hofmann, M., Jaki, T., Gruen, B. & Hothorn, L. A., 03/2015, In: Journal of Immunological Methods. 418, p. 84-100 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  102. Published

    Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa

    Beresford, M. W., Bracaglia, C., Caldas, A., Cimaz, R., Dehoorne, J., Dolezalova, P., Friswell, M., Jelusic, M., Marks, S. D., Martin, N., McMahon, A-M., Peitz, J., van Royen-Kirkhof, A., Soylemezoglu, O., Brogan, P. & MYPAN Vasculitis Expert Group, 30/03/2015, In: PLoS ONE. 10, 3, 14 p., e0120981.

    Research output: Contribution to journalJournal articlepeer-review

  103. Published

    Multi-arm clinical trials with treatment selection: what can be gained and at what price?

    Jaki, T., 04/2015, In: Clinical Investigation. 5, 4, p. 393-399 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  104. Published

    Bayesian sample sizes for exploratory clinical trials comparing multiple experimental treatments with a control

    Whitehead, J., Cleary, F. & Turner, A., 30/05/2015, In: Statistics in Medicine. 34, 12, p. 2048-2061 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  105. Published

    Adaptive clinical trials in tuberculosis: applications, challenges and solutions

    Davis, G. R., Phillips, P. P. & Jaki, T., 1/06/2015, In: International Journal of Tuberculosis and Lung Disease. 19, 6, p. 626-634 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  106. Published

    A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data

    Cotterill, A., Lorand, D., Wang, J. & Jaki, T., 15/06/2015, In: Statistics in Medicine. 34, 13, p. 2138-2164 27 p.

    Research output: Contribution to journalJournal articlepeer-review

  107. Published

    Evaluating differential effects using regression interactions and regression mixture models

    Van Horn, M. L., Jaki, T., Maysn, K., Howe, G., Feaster, D., Lamont, A. E., George, M. & Kim, M., 08/2015, In: Educational and Psychological Measurement. 75, 4, p. 677-714 38 p.

    Research output: Contribution to journalJournal articlepeer-review

  108. Published

    Partial stochastic dominance for the multivariate Gaussian distribution

    Turner, A. & Whitehead, J., 08/2015, In: Statistics and Probability Letters. 103, p. 80-85 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  109. Published

    Sample size considerations in active-control non-inferiority trials with binary data based on the odds ratio

    Siqueira, A. L., Todd, S. & Whitehead, A., 08/2015, In: Statistical Methods in Medical Research. 24, 4, p. 453-461 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  110. Published

    Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of Telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy

    Pushpakom, S. P., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcıa-Finana, M., Kemp, G. J., Whitehead, J., Jaki, T., Khoo, S., Williamson, P. & Pirmohamed, M., 15/10/2015, In: BMJ Open. 5, 10, 13 p., e009566.

    Research output: Contribution to journalJournal articlepeer-review

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