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Medical and Pharmaceutical Statistics Research Unit

  1. Published

    A Bayesian approach for dose-escalation in a phase I clinical trial incorporating pharmacodynamic endpoints .

    Whitehead, J., Hampson, L., Zhou, Y., Ledent, E. & Pereira, A., 11/2007, In: Journal of Biopharmaceutical Statistics. 17, 6, p. 1117-1129 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  2. Published

    A Bayesian approach to dose finding studies for cancer therapies: incorporating later cycles of therapy

    Sinclair, K. & Whitehead, A., 10/07/2014, In: Statistics in Medicine. 33, 15, p. 2665-2680 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    A Bayesian dose-escalation procedure for phase I clinical trials based only on the assumption of monotonicity.

    Whitehead, J., Thygesen, H. & Whitehead, A., 30/07/2010, In: Statistics in Medicine. 29, 17, p. 1808-1824 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    A bivariate Bayesian dose-finding procedure applied to a seamless phase I/II trial in rheumatoid arthritis

    Thygesen, H., Dragalin, V., Whitehead, A. & Whitehead, J., 11/2012, In: Pharmaceutical Statistics. 11, 6, p. 476-484 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    A combined score test for binary and ordinal endpoints from clinical trials.

    Whitehead, J., Branson, M. & Todd, S., 28/02/2010, In: Statistics in Medicine. 29, 5, p. 521-532 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    A comparison of methods for classifying samples as truly specific with confirmatory immunoassays

    Jaki, T., Lawo, J-P., Wolfsegger, M. J., Allacher, P. & Horling, F., 25/01/2014, In: Journal of Pharmaceutical and Biomedical Analysis. 88, p. 27-35 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    A comparison of the barely Bayesian design with the triangular test for clinical trials in infectious diseases

    Whitehead, J. R., 08/2016, In: Clinical Trials. 13, 4, p. 451-453 3 p.

    Research output: Contribution to journalLetterpeer-review

  8. Published

    A false sense of security? can tiered approach be trusted to accurately classify immunogenicity samples?

    Jaki, T. F., Allacher, P. & Horling, F., 5/09/2016, In: Journal of Pharmaceutical and Biomedical Analysis. 128, p. 166-173 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    A formal comparison of different methods for establishing cut points to distinguish positive and negative samples in immunoassays.

    Jaki, T., Lawo, J-P., Wolfsegger, M. J., Singer, J., Allacher, P. & Horling, F., 15/07/2011, In: Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1148-1156 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection

    Magirr, D., Jaki, T. & Whitehead, J., 06/2012, In: Biometrika. 99, 2, p. 494-501 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

    Wolfsegger, M. J., Gutjahr, G., Engl, W. & Jaki, T., 2014, In: Biometrics. 70, 1, p. 103-109 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    A note on statistical analysis of organ weights in non-clinical toxicological studies.

    Wolfsegger, M. J., Jaki, T., Dietrich, B., Kunzler, J. A. & Barker, K., 10/2009, In: Toxicology and Applied Pharmacology. 240, 1, p. 117-122 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

    Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D., 15/08/2012, In: Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data

    Cotterill, A., Lorand, D., Wang, J. & Jaki, T., 15/06/2015, In: Statistics in Medicine. 34, 13, p. 2138-2164 27 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    A quantitative framework to inform extrapolation decisions in children

    Wadsworth, I., Hampson, L. V., Jaki, T., Sills, G. J., Marson, A. G. & Appleton, R., 1/02/2020, In: Journal of the Royal Statistical Society: Series A Statistics in Society. 183, 2, p. 515-534 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    A review of statistical designs for improving the efficiency of phase II studies in oncology

    Wason, J. & Jaki, T., 06/2016, In: Statistical Methods in Medical Research. 25, 3, p. 1010-1021 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    A review of statistical updating methods for clinical prediction models

    Su, T-L., Jaki, T. F., Hickey, G., Buchan, I. & Sperrin, M., 1/01/2018, In: Statistical Methods in Medical Research. 27, 1, p. 185-197 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    A safety monitoring procesure for a clinical drug development programme, with application to the accessment of a novel COX-2 inhibitor.

    Bolland, K., Whitehead, J. & Oldham, M., 07/2008, In: Journal of Biopharmaceutical Statistics. 18, 4, p. 737-749 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    A simple two-stage design for quantitative responses with appliction to a study in diabectic neuropathic pain.

    Whitehead, J., Valdés-Márquez, E. & Lissmats, A., 04/2009, In: Pharmaceutical Statistics. 8, 2, p. 125-135 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    A theoretical framework for estimation of AUCs in complete and incomplete sampling designs.

    Jaki, T. & Wolfsegger, M. J., 05/2009, In: Statistics in Biopharmaceutical Research. 1, 2, p. 176-184 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    A tool to assess the quality of a meta-analysis

    Higgins, J. P. T., Lane, P. W., Anagnostelis, B., Anzures-Cabrera, J., Baker, N. F., Cappelleri, J. C., Haughie, S., Hollis, S., Lewis, S. C., Moneuse, P. & Whitehead, A., 12/2013, In: Research Synthesis Methods. 4, 4, p. 351-366 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme.

    Whitehead, J., Kelly, P., Zhou, Y., Stallard, N., Thygesen, H. & Bowman, C., 10/2009, In: Pharmaceutical Statistics. 8, 4, p. 287-300 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Active-control trials with binary data: a comparison of methods for testing superiority or non-inferiority using the odds ratio.

    Siqueira, A., Whitehead, A. & Todd, S., 10/02/2008, In: Statistics in Medicine. 27, 3, p. 353-370 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Adaptive clinical trials in tuberculosis: applications, challenges and solutions

    Davis, G. R., Phillips, P. P. & Jaki, T., 1/06/2015, In: International Journal of Tuberculosis and Lung Disease. 19, 6, p. 626-634 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    An international multicentre randomized controlled trial of G17DT in patients with pancreatic cancer

    Gilliam, A., Broome, P., Topuzov, E., Garin, A., Pulay, I., Humphreys, J., Whitehead, A., Takhar, A., Rowlands, B. & Beckingham, I., 04/2012, In: Pancreas. 41, 3, p. 374-379 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Analysing malaria drug trials on a per individual or a per clone basis: a comparison of methods

    Jaki, T., Parry, A., Winter, K. & Hastings, I., 30/07/2013, In: Statistics in Medicine. 32, 17, p. 3020-3038 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Assessing differential effects: Applying regression mixture models to identify variations in the influence of family resources on academic achievement.

    Van Horn, M. L., Jaki, T., Maysn, K., Ramey, S. L., Smith, J. A. & Antaramian, S., 09/2009, In: Developmental Psychology. 45, 5, p. 1298-1313 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Assessing systemic drug exposure in repeated dose toxicity studies in the case of complete and incomplete sampling.

    Wolfsegger, M. J. & Jaki, T., 12/2009, In: Biometrical Journal. 51, 6, p. 1017-1026 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Authors' reply to comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data settings"

    Jaki, T., Pallmann, P. & Wolfsegger, M. J., 30/12/2013, In: Statistics in Medicine. 32, 30, p. 5487-5488 2 p.

    Research output: Contribution to journalComment/debate

  30. Published

    Bayesian methods for the design and interpretation of clinical trials in very rare diseases

    Hampson, L., Whitehead, J., Eleftheriou, D. & Brogan, P., 30/10/2014, In: Statistics in Medicine. 33, 24, p. 4186-4201 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Bayesian procedures for phase I/II clinical trials investigating the safety and efficacy of drug combinations

    Whitehead, J., Thygesen, H. & Whitehead, A., 20/07/2011, In: Statistics in Medicine. 30, 16, p. 1952-1970 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Bayesian sample size for exploratory clinical trials incorporating historical data.

    Whitehead, J., Valdés-Márquez, E., Johnson, P. & Graham, G., 06/2008, In: Statistics in Medicine. 27, 13, p. 2307-2327 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Bayesian sample sizes for exploratory clinical trials comparing multiple experimental treatments with a control

    Whitehead, J., Cleary, F. & Turner, A., 30/05/2015, In: Statistics in Medicine. 34, 12, p. 2048-2061 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Bayesian survival analysis in clinical trials: what methods are used in practice?

    Brard, C., Le Teuff, G., Le Deley, M-C. & Hampson, L. V., 1/02/2017, In: Clinical Trials. 14, 1, p. 78-87 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Block response-adaptive randomization in clinical trials with binary endpoints

    Magirr, D., 07/2011, In: Pharmaceutical Statistics. 10, 4, p. 341-346 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Book review : Bioequivalence and statistics in clinical pharmacology.

    Jaki, T., 04/2010, In: Journal of the Royal Statistical Society: Series A Statistics in Society. 173, 2, p. 467-468 2 p.

    Research output: Contribution to journalBook/Film/Article review

  37. Published

    Book review: Applied Nonparametric Statistical Methods.

    Jaki, T., 2008, In: Journal of Biopharmaceutical Statistics. 18, 2, p. 393-395 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    Bridging the gap: a review of dose investigations in paediatric investigation plans

    Hampson, L., Herold, R., Posch, M., Saperia, J. & Whitehead, A., 10/2014, In: British Journal of Clinical Pharmacology. 78, 4, p. 898-907 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    C Code to design error spending tests for delayed responses

    Hampson, L. & Jennison, C., 3/09/2012

    Research output: Exhibits, objects and web-based outputsSoftware

  40. Published

    Cholesterol-lowering effects of oat beta-glucan: a meta-analysis of randomized controlled trials

    Whitehead, A., Beck, E. J., Tosh, S. & Wolever, T. M. S., 1/12/2014, In: American Journal of Clinical Nutrition. 100, 6, p. 1413-1421 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Clinical drug development in epilepsy revisited: a proposal for a new paradigm streamlined using extrapolation

    Wadsworth, I., Jaki, T. F., Sills, G. J., Appleton, R., Cross, J. H., Marson, A. G., Martland, T., McLellan, A., Smith, P. E. M., Pellock, J. M. & Hampson, L. V., 11/2016, In: CNS Drugs. 30, 11, p. 1011-1017 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Confidence Intervals for Ratios of AUC's in the Case of Serial Sampling : A Comparison of Seven Methods.

    Jaki, T., Wolfsegger, M. J. & Ploner, M., 01/2009, In: Pharmaceutical Statistics. 8, 1, p. 12-24 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Considerations on covariates and endpoints in multi-arm multi-stage clinical trials selecting all promising treatments

    Jaki, T. & Magirr, D., 30/03/2013, In: Statistics in Medicine. 32, 7, p. 1150-1163 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Cost-utility analysis conducted alongside randomized controlled trials: Are economic end points considered in sample size calculations and does it matter?

    Hollingworth, W., McKell-Redwood, D., Hampson, L. & Metcalfe, C., 02/2013, In: Clinical Trials. 10, 1, p. 43-53 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Design of the circulation improving resuscitation care (CIRC) trial: a new state of the art design for out-of-hospital cardiac arrest research

    Lerner, E. B., Persse, D., Souders, C., Sterz, F., Malzer, R., Lozano, M., Westfall, M., Brouwer, M. A., Grunsven, P. M. V., Whitehead, A., Olsen, J-A., Herken, U. R. & Wik, L., 03/2011, In: Resuscitation. 82, 3, p. 294-299 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Designing exploratory cancer trials using change in tumour size as primary endpoint

    Jaki, T., Andre, V., Su, T-L. & Whitehead, J., 10/07/2013, In: Statistics in Medicine. 32, 15, p. 2544-2554 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Designing multi-arm multi-stage clinical studies

    Jaki, T., 2014, Developments in statistical evaluation of clinical trials. van Montfort, K., Oud, J. & Ghidey, W. (eds.). Berlin: Springer, p. 51-69 19 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter (peer-reviewed)peer-review

  48. Published

    Designing multi-arm multi-stage clinical trials using a risk-benefit criterion for treatment selection

    Jaki, T. & Hampson, L., 20/02/2016, In: Statistics in Medicine. 35, 4, p. 522-533 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Differential effects of parental controls on adolescent substance use: for whom is the family most important?

    Fagan, A. A., Van Horn, M. L., Hawkins, J. D. & Jaki, T., 09/2013, In: Journal of Quantitative Criminology. 29, 3, p. 347-368 22 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Direct effects testing : a two-stage procedure to test for effect size and variable importance for correlated binary predictors and a binary response.

    Sperrin, M. & Jaki, T., 30/10/2010, In: Statistics in Medicine. 29, 24, p. 2544-2556 13 p.

    Research output: Contribution to journalJournal article

  51. Published

    Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa

    Beresford, M. W., Bracaglia, C., Caldas, A., Cimaz, R., Dehoorne, J., Dolezalova, P., Friswell, M., Jelusic, M., Marks, S. D., Martin, N., McMahon, A-M., Peitz, J., van Royen-Kirkhof, A., Soylemezoglu, O., Brogan, P. & MYPAN Vasculitis Expert Group, 30/03/2015, In: PLoS ONE. 10, 3, 14 p., e0120981.

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    Establishing bioequivalence in complete and incomplete data designs using AUCs.

    Jaki, T., Wolfsegger, M. J. & Lawo, J-P., 07/2010, In: Journal of Biopharmaceutical Statistics. 20, 4, p. 803-820 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  53. Published

    Estimation following selection of the largest of two normal means. Journal of Statistical Planning and Inference 138, 1629-1638.

    Stallard, N., Todd, S. & Whitehead, J., 1/07/2008, In: Journal of Statistical Planning and Inference. 138, 6, p. 1629-1638 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs

    Jaki, T., Pallmann, P. & Wolfsegger, M. J., 30/12/2013, In: Statistics in Medicine. 32, 30, p. 5469-5483 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Estimation of pharmacokinetic parameters with the R package PK.

    Jaki, T. & Wolfsegger, M. J., 05/2011, In: Pharmaceutical Statistics. 10, 2, p. 284-288 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    Estimation of treatment effects following a sequential trial of multiple treatments

    Whitehead, J., Desai, Y. & Jaki, T., 20/05/2020, In: Statistics in Medicine. 39, 11, p. 1593-1609 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    Evaluating differential effects using regression interactions and regression mixture models

    Van Horn, M. L., Jaki, T., Maysn, K., Howe, G., Feaster, D., Lamont, A. E., George, M. & Kim, M., 08/2015, In: Educational and Psychological Measurement. 75, 4, p. 677-714 38 p.

    Research output: Contribution to journalJournal articlepeer-review

  58. Published

    Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline.

    Bolland, K., Whitehead, J., Cobo, E. & Secades, J. J., 04/2009, In: Pharmaceutical Statistics. 8, 2, p. 136-149 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  59. Published

    Exercise and self-management for people with chronic knee, hip or lower back pain: a cluster randomised controlled trial of clinical and cost-effectiveness. Study protocol

    Walsh, N., Cramp, F., Palmer, S., Pollock, J., Hampson, L., Gooberman-Hill, R., Green, C., Jones, L., Phillips, S., Johnson, L. & Hurley, M., 12/2013, In: Physiotherapy. 99, 4, p. 352-357 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  60. Published

    Experimental treatment of Ebola virus disease with TKM-130803: a single-arm phase 2 clinical trial

    RAPIDE-TKM trial team, 19/04/2016, In: PLoS Medicine. 13, 4, 19 p., e1001997.

    Research output: Contribution to journalJournal articlepeer-review

  61. Published

    Exposure–response modelling approaches for determining optimal dosing rules in children

    Wadsworth, I., Hampson, L. V., Bornkamp, B. & Jaki, T., 1/09/2020, In: Statistical Methods in Medical Research. 29, 9, p. 2583-2602 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. Published

    Extrapolation of efficacy and other data to support the development of new medicines for children: a systematic review of methods

    Wadsworth, I., Hampson, L. V. & Jaki, T. F., 1/02/2018, In: Statistical Methods in Medical Research. 27, 2, p. 398-413 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  63. Published

    Factorial versus multi-arm multi-stage designs for clinical trials with multiple treatments

    Jaki, T. F. & Vasileiou, D., 20/02/2017, In: Statistics in Medicine. 36, 4, p. 563-580 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  64. Published

    Finite mixtures for simultaneously modelling differential effects and non-normal distributions

    George, M., Yang, N., Jaki, T., Feaster, D., Lamont, A. E., Van Horn, M. L. & Wilson, D. K., 2013, In: Multivariate Behavioral Research. 48, 6, p. 816-844 29 p.

    Research output: Contribution to journalJournal articlepeer-review

  65. Published

    Fitting models for the joint action of two drugs using SAS(R).

    Whitehead, A., Whitehead, J., Todd, S., Zhou, Y. & Smith, M. K., 10/2008, In: Pharmaceutical Statistics. 7, 4, p. 272-284 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  66. Published

    Flexible sequential designs for multi-arm clinical trials

    Magirr, D., Stallard, N. & Jaki, T., 30/08/2014, In: Statistics in Medicine. 33, 19, p. 3269-3279 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  67. Published

    Geostatistical inference under preferential sampling

    Diggle, P. J., Menezes, R. & Su, T., 03/2010, In: Journal of the Royal Statistical Society: Series C (Applied Statistics). 59, 2, p. 191-232 42 p.

    Research output: Contribution to journalJournal articlepeer-review

  68. Published

    Group sequential tests for delayed responses

    Hampson, L. & Jennison, C., 01/2013, In: Journal of the Royal Statistical Society: Series B (Statistical Methodology). 75, 1, p. 3-54 52 p.

    Research output: Contribution to journalJournal articlepeer-review

  69. Published

    Identification of Predicted Individual Treatment Effects (PITE) in randomized clinical trials

    Lamont, A. E., Lyons, M., Jaki, T. F., Stuart, E. A., Feaster, D., Ishwaran, H., Tharmaratnam, K. & Van Horn, M. L., 1/01/2018, In: Statistical Methods in Medical Research. 27, 1, p. 142-157 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  70. Published

    Impact of an equality constraint on the class-specific residual variances in regression mixtures: a Monte Carlo simulation study

    Kim, M., Lamont, A. E., Jaki, T., Feaster, D., Howe, G. & Van Horn, M. L., 06/2016, In: Behavior Research Methods. 48, 2, p. 813-826 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  71. Published

    Implementation of a Bayesian design in a dose-escalation study of an experimental agent in healthy volunteers.

    Whitehead, J., Korhonen, P., Mustonen, M. & Zhou, Y., 03/2008, In: Biometrics. 64, 1, p. 299-308 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  72. Published

    Incorporating intermediate binary responses into interim analyses of clinical trials : a comparison of four methods.

    Whitehead, A., Sooriyarachchi, M. R., Whitehead, J. & Bolland, K., 10/05/2008, In: Statistics in Medicine. 27, 10, p. 1646-1666 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  73. Published

    Incorporating prognostic factors into causal estimators: a comparison of methods for RCTs with a time to event outcome

    Hampson, L. & Metcalfe, C., 20/11/2012, In: Statistics in Medicine. 31, 26, p. 3073-3088 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  74. Published

    Investigating the assumption of homogeneity of treatment effects in clincal studies with application to meta-analysis

    Julious, S. & Whitehead, A., 01/2012, In: Pharmaceutical Statistics. 11, 1, p. 49-56 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  75. Published

    Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest: the randomized CIRC trial

    Wik, L., Olsen, J-A., Persse, D., Sterz, F., Lozano Jr, M., Brouwer, M. A., Westfall, M., Souders, C., Malzer, R., Grunsven, P. M. V., Travis, D., Whitehead, A., Herken, U. R. & Lerner, E. B., 06/2014, In: Resuscitation. 85, 6, p. 741-748 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  76. Published

    Maximum kernel likelihood estimation

    Jaki, T. & West, R. W., 2008, In: Journal of Computational and Graphical Statistics. 17, 4, p. 976-993 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  77. Published

    Meta-analysis of individual patient data versus aggregate data from longitudinal clinical trials.

    Jones, A., Riley, R., Williamson, P. & Whitehead, A., 02/2009, In: Clinical Trials. 6, 1, p. 16-27 12 p.

    Research output: Contribution to journalJournal article

  78. Published

    Methodological quality of meta-analyses: matched-pairs comparison over time and between industry sponsored and academic-sponsored reports

    Lane, P. W., Higgins, J. P. T., Anagnostelis, B., Anzures-Cabrera, J., Baker, N. F., Cappelleri, J. C., Haughie, S., Hollis, S., Lewis, S. C., Moneuse, P. & Whitehead, A., 12/2013, In: Research Synthesis Methods. 4, 4, p. 342-350 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  79. Published

    Model selection based on combined penalties for biomarker identification

    Vradi, E., Brannath, W., Jaki, T. & Vonk, R., 4/07/2018, In: Journal of Biopharmaceutical Statistics. 28, 4, p. 735-749 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  80. Published

    Modeling predictors of latent classes in regression mixture models

    Kim, M., Vermunt, J., Bakk, Z., Jaki, T. F. & Van Horn, M. L., 06/2016, In: Structural Equation Modeling. 23, 4, p. 601-614 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  81. Published

    Mometasone furoate cream reduces acute radiation dermatitis in patients receiving breast radiation therapy: results of a randomized trial

    Hindley, A., Zain, Z., Wood, L., Whitehead, A., Sanneh, A., Barber, D. & Hornsby, R., 15/11/2014, In: International Journal of Radiation Oncology - Biology - Physics. 90, 4, p. 748-755 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  82. Published

    Mometasone Furoate significantly reduces radiation dermatitis in patients undergoing breast radiation therapy: a double-blind randomized control trial in 120 patients

    Dunn, K., Hindley, A., Wood, L., Sanneh, A., Barber, D., Whitehead, A. & Zain, Z., 10/2013, In: International Journal of Radiation Oncology - Biology - Physics. 87, 2 Supplement, p. S115 1 p.

    Research output: Contribution to journalMeeting abstract

  83. Published

    Multi-arm clinical trials with treatment selection: what can be gained and at what price?

    Jaki, T., 04/2015, In: Clinical Investigation. 5, 4, p. 393-399 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  84. Published

    Multiplicity: discussion points from the PSI multiplicity expert group

    Phillips, A., Fletcher, C., Atkinson, G., Channon, E., Douiri, A., Jaki, T., Maca, J., Morgan, D., Roger, J. H. & Terrill, P., 09/2013, In: Pharmaceutical Statistics. 12, 5, p. 255-259 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  85. Published

    Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs

    Jaki, T. & Wolfsegger, M. J., 2012, In: Statistics in Medicine. 31, 11-12, p. 1059-1073 25 p.

    Research output: Contribution to journalJournal articlepeer-review

  86. Published

    Non-compartmental estimation of pharmacokinetic parameters in serial sampling designs.

    Wolfsegger, M. J. & Jaki, T., 10/2009, In: Journal of Pharmacokinetics and Pharmacodynamics. 36, 5, p. 479-494

    Research output: Contribution to journalJournal articlepeer-review

  87. Published

    Not quite normal: Consequences of violating the assumption of normality with regression mixture models

    Van Horn, M. L., Smith, J., Fagan, A., Jaki, T., Maysn, K., Hawkins, D., Feaster, D. & Howe, G., 2012, In: Structural Equation Modeling. 19, 2, p. 227-249 23 p.

    Research output: Contribution to journalJournal articlepeer-review

  88. Published

    One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.

    Whitehead, J. & Jaki, T., 28/02/2009, In: Statistics in Medicine. 28, 5, p. 828-847 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  89. Published

    Optimal design of multi-arm multi-stage trials

    Wason, J. & Jaki, T., 30/12/2012, In: Statistics in Medicine. 31, 30, p. 4269-4279 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  90. Published

    Optimising the data combination rule for seamless phase II/III clinical trials

    Hampson, L. & Jennison, C., 01/2015, In: Statistics in Medicine. 34, 1, p. 39-58 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  91. Published

    Optimization, refinement and reduction of murine in vivo experiments to assess therapeutic approaches for hemophilia A.

    Baumgartner, B., Jaki, T., Wolfsegger, M. J., Eder, B., Schiviz, A., Schwarz, H. P. & Muchitsch, E. M., 07/2010, In: Laboratory Animals. 44, 3, p. 211-217 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  92. Published

    Partial stochastic dominance for the multivariate Gaussian distribution

    Turner, A. & Whitehead, J., 08/2015, In: Statistics and Probability Letters. 103, p. 80-85 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  93. Published

    Planning multi-arm screening studies within the context of a drug development programme

    Wason, J., Jaki, T. & Stallard, N., 10/09/2013, In: Statistics in Medicine. 32, 20, p. 3424-3435 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  94. Published

    Principles of dose finding studies in cancer: a comparison of trial designs

    Jaki, T., Clive, S. & Weir, C., 05/2013, In: Cancer Chemotherapy and Pharmacology. 71, 5, p. 1107-1114 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  95. Published

    Probabilistic relabelling strategies for the label switching problem in Bayesian mixture models.

    Sperrin, M., Jaki, T. & Wit, E., 07/2010, In: Statistics and Computing. 20, 3, p. 357-366 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  96. Published
  97. Published

    Recording lectures as a service in a service course.

    Jaki, T., 11/2009, In: Journal of Statistics Education. 17, 3

    Research output: Contribution to journalJournal articlepeer-review

  98. Published

    Recovering Independent Associations in Genetics: A Comparison

    Sperrin, M. & Jaki, T., 08/2012, In: Journal of Computational Biology. 19, 8, p. 978–987 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  99. Published

    Recurrent events modelling of haemophilia bleeding events

    Titman, A., Wolfsegger, M. J. & Jaki, T., 31/03/2021, In: Journal of the Royal Statistical Society: Series C (Applied Statistics). 70, 2, p. 351-371 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  100. Published

    Sample size considerations in active-control non-inferiority trials with binary data based on the odds ratio

    Siqueira, A. L., Todd, S. & Whitehead, A., 08/2015, In: Statistical Methods in Medical Research. 24, 4, p. 453-461 9 p.

    Research output: Contribution to journalJournal articlepeer-review

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