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Medical and Pharmaceutical Statistics Research Unit

  1. Published

    A Bayesian approach for dose-escalation in a phase I clinical trial incorporating pharmacodynamic endpoints .

    Whitehead, J., Hampson, L., Zhou, Y., Ledent, E. & Pereira, A., 11/2007, In: Journal of Biopharmaceutical Statistics. 17, 6, p. 1117-1129 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  2. Published

    A Bayesian approach to dose finding studies for cancer therapies: incorporating later cycles of therapy

    Sinclair, K. & Whitehead, A., 10/07/2014, In: Statistics in Medicine. 33, 15, p. 2665-2680 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    A Bayesian dose-escalation procedure for phase I clinical trials based only on the assumption of monotonicity.

    Whitehead, J., Thygesen, H. & Whitehead, A., 30/07/2010, In: Statistics in Medicine. 29, 17, p. 1808-1824 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    A bivariate Bayesian dose-finding procedure applied to a seamless phase I/II trial in rheumatoid arthritis

    Thygesen, H., Dragalin, V., Whitehead, A. & Whitehead, J., 11/2012, In: Pharmaceutical Statistics. 11, 6, p. 476-484 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    A combined score test for binary and ordinal endpoints from clinical trials.

    Whitehead, J., Branson, M. & Todd, S., 28/02/2010, In: Statistics in Medicine. 29, 5, p. 521-532 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    A comparison of methods for classifying samples as truly specific with confirmatory immunoassays

    Jaki, T., Lawo, J-P., Wolfsegger, M. J., Allacher, P. & Horling, F., 25/01/2014, In: Journal of Pharmaceutical and Biomedical Analysis. 88, p. 27-35 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    A comparison of the barely Bayesian design with the triangular test for clinical trials in infectious diseases

    Whitehead, J. R., 08/2016, In: Clinical Trials. 13, 4, p. 451-453 3 p.

    Research output: Contribution to journalLetterpeer-review

  8. Published

    A false sense of security? can tiered approach be trusted to accurately classify immunogenicity samples?

    Jaki, T. F., Allacher, P. & Horling, F., 5/09/2016, In: Journal of Pharmaceutical and Biomedical Analysis. 128, p. 166-173 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    A formal comparison of different methods for establishing cut points to distinguish positive and negative samples in immunoassays.

    Jaki, T., Lawo, J-P., Wolfsegger, M. J., Singer, J., Allacher, P. & Horling, F., 15/07/2011, In: Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1148-1156 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection

    Magirr, D., Jaki, T. & Whitehead, J., 06/2012, In: Biometrika. 99, 2, p. 494-501 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

    Wolfsegger, M. J., Gutjahr, G., Engl, W. & Jaki, T., 2014, In: Biometrics. 70, 1, p. 103-109 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    A note on statistical analysis of organ weights in non-clinical toxicological studies.

    Wolfsegger, M. J., Jaki, T., Dietrich, B., Kunzler, J. A. & Barker, K., 10/2009, In: Toxicology and Applied Pharmacology. 240, 1, p. 117-122 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

    Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D., 15/08/2012, In: Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. E-pub ahead of print

    A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule

    Barnett, H. Y., Villar, S. S., Geys, H. & Jaki, T., 8/11/2021, (E-pub ahead of print) In: Biometrics.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data

    Cotterill, A., Lorand, D., Wang, J. & Jaki, T., 15/06/2015, In: Statistics in Medicine. 34, 13, p. 2138-2164 27 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    A quantitative framework to inform extrapolation decisions in children

    Wadsworth, I., Hampson, L. V., Jaki, T., Sills, G. J., Marson, A. G. & Appleton, R., 1/02/2020, In: Journal of the Royal Statistical Society: Series A Statistics in Society. 183, 2, p. 515-534 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    A review of statistical designs for improving the efficiency of phase II studies in oncology

    Wason, J. & Jaki, T., 06/2016, In: Statistical Methods in Medical Research. 25, 3, p. 1010-1021 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    A review of statistical updating methods for clinical prediction models

    Su, T-L., Jaki, T. F., Hickey, G., Buchan, I. & Sperrin, M., 1/01/2018, In: Statistical Methods in Medical Research. 27, 1, p. 185-197 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    A safety monitoring procesure for a clinical drug development programme, with application to the accessment of a novel COX-2 inhibitor.

    Bolland, K., Whitehead, J. & Oldham, M., 07/2008, In: Journal of Biopharmaceutical Statistics. 18, 4, p. 737-749 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    A simple two-stage design for quantitative responses with appliction to a study in diabectic neuropathic pain.

    Whitehead, J., Valdés-Márquez, E. & Lissmats, A., 04/2009, In: Pharmaceutical Statistics. 8, 2, p. 125-135 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    A theoretical framework for estimation of AUCs in complete and incomplete sampling designs.

    Jaki, T. & Wolfsegger, M. J., 05/2009, In: Statistics in Biopharmaceutical Research. 1, 2, p. 176-184 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    A tool to assess the quality of a meta-analysis

    Higgins, J. P. T., Lane, P. W., Anagnostelis, B., Anzures-Cabrera, J., Baker, N. F., Cappelleri, J. C., Haughie, S., Hollis, S., Lewis, S. C., Moneuse, P. & Whitehead, A., 12/2013, In: Research Synthesis Methods. 4, 4, p. 351-366 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme.

    Whitehead, J., Kelly, P., Zhou, Y., Stallard, N., Thygesen, H. & Bowman, C., 10/2009, In: Pharmaceutical Statistics. 8, 4, p. 287-300 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Active-control trials with binary data: a comparison of methods for testing superiority or non-inferiority using the odds ratio.

    Siqueira, A., Whitehead, A. & Todd, S., 10/02/2008, In: Statistics in Medicine. 27, 3, p. 353-370 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    Adaptive clinical trials in tuberculosis: applications, challenges and solutions

    Davis, G. R., Phillips, P. P. & Jaki, T., 1/06/2015, In: International Journal of Tuberculosis and Lung Disease. 19, 6, p. 626-634 9 p.

    Research output: Contribution to journalJournal articlepeer-review

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