Andrew Fielding

Academic

Biomedical and Life Sciences
Cancer Biology and Genome Stability

Type of address: Postal address.

Furness Building

LA1 4YG

Lancaster

Email: a.fielding1@lancaster.ac.uk

SUMMARY of research interests (100 words)

Cancer is a disease characterised by errors in cell cycle regulation, leading to uncontrolled cell proliferation. However, these errors also lead to cancer cells possessing unique phenotypes, such as centrosome amplification, which could potentially decrease their survival. In my laboratory we aim to understand these phenotypes and in turn target these to provide cancer-specific methods for inhibiting cell proliferation.

Employment

Senior Lecturer in Cancer Research

Academic

Biomedical and Life Sciences

Lancaster University

Lancaster, United Kingdom

11/09/2023 → present

Cancer Biology and Genome Stability

Lancaster University

1/10/2022 → present

Senior Lecturer in Cancer Research

Academic

Biomedical and Life Sciences

Lancaster University

Lancaster, United Kingdom

1/08/2023 → 10/09/2023

Senior Lecturer in Cancer Research

Academic

Biomedical and Life Sciences

Lancaster University

Lancaster, United Kingdom

19/03/2018 → 31/07/2023

External Examiner MSc Cancer Biology and Therapy

The University of Liverpool

United Kingdom

1/02/2024 → 1/02/2028

Research outputs

OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival

Marotta, V. E., Sabat-Pośpiech, D., Fielding, A. B., Ponsford, A. H., Thomaz, A., Querques, F., Morgan, M. R., Prior, I. A. & Coulson, J. M., 24/02/2025, In: EMBO Reports. 26, 4, p. 1003-1035 33 p.

Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention

Sabat‐Pośpiech, D., Fabian‐Kolpanowicz, K., Kalirai, H., Kipling, N., Coupland, S. E., Coulson, J. M. & Fielding, A. B., 31/07/2022, In: The Journal of Pathology: Clinical Research. 8, 4, p. 383-394 12 p.

Targeting centrosome amplification, an Achilles' heel of cancer

Sabat-Pośpiech, D., Fabian-Kolpanowicz, K., Prior, I. A., Coulson, J. M. & Fielding, A. B., 31/10/2019, In: Biochemical Society Transactions. 47, 5, p. 1209-1222 14 p.

Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma

Jama, N., Farquhar, N., Butt, Z., Coupland, S. E., Sacco, J. J., Scase, T., Fielding, A. B., Coulson, J. M., Kalirai, H. & Killick, D. R., 07/2018, In: Journal of Comparative Pathology. 162, p. 50-58 9 p.

The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity

Fielding, A. B., Concannon, M., Darling, S., Rusilowicz-Jones, E. V., Sacco, J. J., Prior, I. A., Clague, M. J., Urbé, S. & Coulson, J. M., 04/2018, In: Oncogene. 37, p. 2326-2342 17 p.

Regulation of the cell cycle and centrosome biology by deubiquitylases

Darling, S., Fielding, A. B., Sabat-Pośpiech, D., Prior, I. A. & Coulson, J. M., 15/10/2017, In: Biochemical Society Transactions. 45, 5, p. 1125-1136 12 p.

Isolating HeLa cell fractions enriched for clathrin-coated vesicles

Borner, G. H. H. & Fielding, A. B., 3/11/2014, In: Cold Spring Harbor Protocols. 2014, 11, p. 1184-1187 4 p.

Isolation of clathrin-coated vesicles from tissue culture cells

Borner, G. H. H. & Fielding, A. B., 3/11/2014, In: Cold Spring Harbor Protocols. 2014, 11, p. 1136-1138 3 p.

Using in-gel digestion and an Orbitrap mass spectrometer to analyze the proteome of clathrin-coated vesicles

Borner, G. H. H. & Fielding, A. B., 3/11/2014, In: Cold Spring Harbor Protocols. 2014, 11, p. 1188-1191 4 p.

Using in-solution digestion, peptide fractionation, and a Q exactive mass spectrometer to analyze the proteome of clathrin-coated vesicles

Borner, G. H. H. & Fielding, A. B., 3/11/2014, In: Cold Spring Harbor Protocols. 2014, 11, p. 1192-1195 4 p.

An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis

Kaur, S., Fielding, A. B., Gassner, G., Carter, N. J. & Royle, S. J., 18/02/2014, In: eLife. 3, 17 p., e00829.

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

Kawamura, E., Fielding, A. B., Kannan, N., Balgi, A., Eaves, C. J., Roberge, M. & Dedhar, S., 10/2013, In: Oncotarget. 4, 10, p. 1763-1776 14 p.

Mitotic inhibition of clathrin-mediated endocytosis

Fielding, A. B., 09/2013, In: Cellular and Molecular Life Sciences : CMLS. 70, 18, p. 3423-3433 11 p.

Integrin-linked kinase regulates interphase and mitotic microtubule dynamics

Lim, S., Kawamura, E., Fielding, A. B., Maydan, M. & Dedhar, S., 21/01/2013, In: PLoS ONE. 8, 1, 11 p., e53702.

Clathrin-mediated endocytosis is inhibited during mitosis

Fielding, A. B., Willox, A. K., Okeke, E. & Royle, S. J., 24/04/2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6572-6577 6 p.

A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells

Fielding, A. B., Lim, S., Montgomery, K., Dobreva, I. & Dedhar, S., 3/02/2011, In: Oncogene. 30, 5, p. 521-534 14 p.

The mitotic functions of integrin-linked kinase

Fielding, A. B. & Dedhar, S., 06/2009, In: Cancer Metastasis Reviews. 28, 1-2, p. 99-111 13 p.

Integrin-linked kinase--essential roles in physiology and cancer biology

McDonald, P. C., Fielding, A. B. & Dedhar, S., 1/10/2008, In: Journal of Cell Science. 121, 19, p. 3121-3132 12 p.

Beyond focal adhesions: integrin-linked kinase associates with tubulin and regulates mitotic spindle organization

Fielding, A. B., Dobreva, I. & Dedhar, S., 1/07/2008, In: Cell Cycle. 7, 13, p. 1899-1906 8 p.

Mapping the integrin-linked kinase interactome using SILAC

Dobreva, I., Fielding, A., Foster, L. J. & Dedhar, S., 04/2008, In: Journal of Proteome Research. 7, 4, p. 1740-1749 10 p.

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization

Fielding, A. B., Dobreva, I., McDonald, P. C., Foster, L. J. & Dedhar, S., 25/02/2008, In: Journal of Cell Biology. 180, 4, p. 681-9 9 p.

Membrane traffic in cytokinesis

Matheson, J., Yu, X., Fielding, A. B. & Gould, G. W., 12/2005, In: Biochemical Society Transactions. 33, Pt 6, p. 1290-1294 5 p.

Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis

Schonteich, E., Fielding, A. B., Matheson, J., Wilson, G., Yu, X., Hickson, G. R. X., Srivastava, S., Baldwin, S. A., Prekeris, R. & Gould, G. W., 5/10/2005, In: EMBO Journal. 24, 19, p. 3389-99 11 p.

The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis

Wilson, G. M., Fielding, A. B., Simon, G. C., Yu, X., Andrews, P. D., Hames, R. S., Frey, A. M., Peden, A. A., Gould, G. W. & Prekeris, R., 02/2005, In: Molecular Biology of the Cell. 16, 2, p. 849-860 12 p.

Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout

Hickson, G. R. X., Matheson, J., Riggs, B., Maier, V. H., Fielding, A. B., Prekeris, R., Sullivan, W., Barr, F. A. & Gould, G. W., 07/2003, In: Molecular Biology of the Cell. 14, 7, p. 2908-2920 13 p.

Structure-function relationships of a novel bacterial toxin, hemolysin E. The role of alpha G

Atkins, A., Wyborn, N. R., Wallace, A. J., Stillman, T. J., Black, L. K., Fielding, A. B., Hisakado, M., Artymiuk, P. J. & Green, J., 29/12/2000, In: Journal of Biological Chemistry. 275, 52, p. 41150-41155 6 p.

Activities

Developing therapeutics against the kinesin KIFC1 as treatments for triple negative breast cancer

Fielding, A. (Speaker)

2/07/2025

Pharmacology & Pharmaceutical Science: solutions in health, from lab to life - Lancaster University

Hall, S. (Speaker) & Fielding, A. (Speaker)

24/06/2025

External Examiner, PhD

Fielding, A. (Examiner)

8/05/2025

International Educational Consultants

Fielding, A. (Advisor)

4/03/2025

External Examiner, PhD

Fielding, A. (Examiner)

28/02/2025

Chemistry – Biology collaborations in the quest to find the treatments of the future

Munoz-Herranz, M. P. (Speaker) & Fielding, A. (Speaker)

10/12/2024

In Microns

Benedetto, A. (Organiser), Wright, K. (Organiser), Fielding, A. (Contributor), Jackson-Jones, L. (Contributor), Mort, R. (Contributor), Whittingham-Dowd, J. (Contributor), Shaw, E. (Contributor), Hawkes, C. (Contributor), Broughton, S. (Contributor), Clancy, D. (Contributor), Unterholzner, L. (Contributor), Copeland, N. (Contributor), Allinson, S. (Contributor), Rigby, R. (Contributor), West, A. (Presenter), Callanan, D. (Presenter) & Harris, G. (Organiser)

7/11/2024 → 9/11/2024

Light up Lancaster 2024: In Microns

Fielding, A. (Speaker)

7/11/2024 → 9/11/2024

Lead session "IP in the Biosciences", as part of PGR training series

Fielding, A. (Speaker)

5/11/2024

Invited Speaker at NWCR Fundraising Event: Liverpool

Fielding, A. (Speaker)

11/10/2024

FHM Engagment Day: Invited Talk on "Your intellectual property and how to protect it – and maximise its value."

Fielding, A. (Speaker)

24/09/2024

Internal Examiner, PhD

Fielding, A. (Examiner)

1/07/2024 → 1/09/2024

External Examiner MSc by Research

Fielding, A. (Examiner)

26/06/2024

FHM Promotion Workshop for academic staff

Fielding, A. (Speaker)

25/06/2024

Designated Safeguarding Lead Training Level 3

Fielding, A. (Participant)

24/06/2024

IP in HealthcareConference 2024, HGF

Fielding, A. (Participant), Wenmouth, J. (Participant) & Jones, G. (Participant)

19/06/2024

STEM Taster Event 2024

Fielding, A. (Contributor), Hammond, J. (Organiser) & Allinson, S. (Organiser)

19/06/2024 → 20/06/2024

Campus in the City 2024

Fielding, A. (Organiser)

11/04/2024 → 13/04/2024

AdvanceHE Professional Development Course for External Examiners

Fielding, A. (Participant)

9/04/2024

North West Melanoma Interest Group

Mort, R. (Organiser), Fielding, A. (Organiser), Marie, K. (Organiser) & Thomaz, A. (Organiser)

26/03/2024

Internal Examiner MSc by Research

Fielding, A. (Examiner)

8/03/2024

External Examiner for MSc Cancer Biology and Therapy, University of Liverpool

Fielding, A. (Examiner)

1/02/2024 → 1/02/2028

North West Cancer Research Lunesdale Committee Campus Visit

Fielding, A. (Speaker)

16/10/2023

North West Cancer Research Fundraisers Departmental Visit

Fielding, A. (Organiser)

27/09/2023

North West Melanoma Meeting

Fielding, A. (Participant)

14/09/2023

North West Cancer Research Symposium 2023

Fielding, A. (Organiser)

5/07/2023

FURNESS STEM SHOW 2023

Jackson-Jones, L. (Organiser), Allinson, S. (Organiser), Shih, B. (Presenter), Hammond, J. (Contributor), Zarate Potes, A. (Presenter), Weight, C. (Presenter), Hardgrave, A. (Presenter), Barnes, C. (Presenter), Dewar, C. (Presenter), Macharia, S. (Presenter), Iqbal, N. (Presenter), Fielding, A. (Presenter) & Urbaniak, M. (Contributor)

14/03/2023 → 15/03/2023

FHM Promotion Workshop for academic staff

Fielding, A. (Speaker)

9/03/2023

MSc by Research Viva: BLS

Fielding, A. (Examiner)

19/12/2022

Lancaster mini melanocyte Symposium 2022

Mort, R. (Organiser), Brennan, L. (Speaker), Fielding, A. (Speaker), Jivanji, S. (Speaker), Briggs, T. (Participant), Pomfret, L. (Speaker), Yates, C. A. (Speaker), Littlejohn, M. (Participant), Marie, K. (Speaker), Swaminathan, K. (Speaker), Thomaz, A. (Participant) & Fabian-Kolpanowicz, K. (Speaker)

11/07/2022

External examiner for PhD viva

Fielding, A. (Examiner)

24/05/2022

MSc by Research: Internal examiner

Fielding, A. (Examiner)

11/01/2022

External examiner for PhD viva

Fielding, A. (Examiner)

26/05/2021

MSc by Research viva: Internal examiner

Fielding, A. (Examiner)

18/12/2020

Investigative Ophthalmology and Visual Science (Journal)

Fielding, A. (Peer reviewer)

1/12/2019 → 31/12/2019

Chamber of Commerce BLS visit on behalf of NWCR

Fielding, A. (Host)

22/10/2019

"Strawberry DNA" primary school visits, jointly hosted by NWCR researchers and the students union.

Fielding, A. (Speaker)

1/10/2019 → 30/07/2020

MSc by research viva: Internal examiner

Fielding, A. (Examiner)

20/09/2019

Keynote speaker on Biostatistics and Epidemiology: Cancer Course

Fielding, A. (Consultant)

15/09/2019 → 16/09/2019

Morecambe Carnival, "all about DNA" hands-on stand.

Fielding, A. (Participant)

11/08/2019

NW Ubiquitylation and Cell cycle Meeting

Fielding, A. (Organiser)

2/07/2019

Internal examiner for PhD candidate

Fielding, A. (Examiner)

13/06/2019

Invited talk at NW DNA-repair network meeting

Fielding, A. (Speaker)

11/04/2019

Campus in the City 2019

Fielding, A. (Participant)

4/04/2019

Talk at British Society of Cell Biology Annual Meeting

Fielding, A. (Speaker)

04/2019

Prof Fred Currell, Director of Dalton Cumbria Facility, BLS visit and Departmental Seminar

Fielding, A. (Host)

27/03/2019

Dalton Cumbrian Facility: Inaugral Biohealth meeting

Fielding, A. (Participant)

21/01/2019

Internal Examiner for Lily Dixon, MSc by Research, FHM

Fielding, A. (Examiner)

19/12/2018

NWCR Lunesdale Committee AGM

Fielding, A. (Speaker)

17/10/2018

"Strawberry DNA" primary school visits, jointly hosted by NWCR researchers and the students union.

Fielding, A. (Contributor)

1/10/2018 → 30/04/2019

Ripley St Thomas: School Outreach

Fielding, A. (Speaker)

21/09/2018

Short talk at ARVO Ocular Oncogenesis Conference

Fielding, A. (Speaker)

18/07/2018 → 21/07/2018

Work Experience in Cancer Research

Fielding, A. (Speaker)

9/07/2018

Talk at University of Liverpool NWCR Centre Seminar Series

Fielding, A. (Speaker)

29/06/2018

The University of Liverpool

Fielding, A. (Visiting researcher)

10/05/2018

NWCR/UoL hosted visit for Local Primary School

Fielding, A. (Speaker)

3/05/2018

Lab tours on behalf of North-West Cancer Research for Lancaster House Staff

Fielding, A. (Speaker)

1/05/2018 → 1/07/2018

Invited talk at North-West Cancer Research Annual Symposium

Fielding, A. (Speaker)

20/04/2018

Genome Stability Meeting

Fielding, A. (Participant)

18/04/2018

Managing, motivating and developing your researchers

Fielding, A. (Participant)

17/04/2018

Prizes

Nominated for a 2025 Dean’s Award (Team category)

Fielding, A. (Recipient), 2025

NWCR 70th Anniversary Award: Rising Star in Research

Fielding, A. (Recipient), 29/09/2018

Awards

Optimisation and pre-clinical development of a KIFC1-PROTAC as a triple-negative breast cancer therapeutic

Fielding, A. (PI)

North West Cancer Research Fund: £221,127.36

10/06/24 → 10/06/27

Award date: 10/06/24

Small molecule induced degradation of centrosome clustering proteins: development of a novel, cancer-specific therapeutic approach

Fielding, A. (PI)

North West Cancer Research Fund: £232,696.52

27/01/20 → 31/10/23

Award date: 4/09/19

Investigating the thermosensitivity of cancer cell division dynamics: toward cancer thermotherapies?

Benedetto, A. (PI), Fielding, A. (CoI) & Mort, R. (CoI)

North West Cancer Research Fund: £15,030.00

1/07/19 → 30/09/20

Award date: 17/06/19

Projects

Investigating the thermosensitivity of cancer cell division dynamics: toward cancer thermotherapies?

Benedetto, A. (Principal Investigator), Mort, R. (Co-Investigator) & Fielding, A. (Co-Investigator)

North West Cancer Research Fund

1/07/19 → 30/09/20

NWCR Summer Studentship Renewal

Allinson, S. (Principal Investigator), Parkin, E. (Co-Investigator), Copeland, N. (Co-Investigator), Fielding, A. (Co-Investigator), Rigby, R. (Co-Investigator) & Jackson-Jones, L. (Co-Investigator)

North West Cancer Research Fund

1/07/21 → 30/09/21

Optimisation and pre-clinical development of a KIFC1-PROTAC as a triple-negative breast cancer therapeutic

Fielding, A. (Principal Investigator)

10/06/24 → 10/06/27

Small molecule induced degradation of centrosome clustering proteins: development of a novel, cancer-specific therapeutic approach

Fielding, A. (CoPI), Gadd, M. (CoPI) & Thomaz, A. (Research Associate)

North West Cancer Research Fund

27/01/20 → 31/10/23