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Research

Professor Christian Holscher

Formerly at Lancaster University

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  1. Published

    Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue

    Graham, S. F., Holscher, C. & Green, B. D., 08/2014, In: Metabolomics. 10, 4, p. 744-753 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's Disease and dementia with Lewy bodies

    Graham, S. F., Nasarauddin, M. B., Carey, M., McGuinness, B., Holscher, C., Kehoe, P. G., Love, S., Passmore, A. P., Elliott, C. T., Meharg, A. & Green, B. D., 2015, In: Journal of Alzheimer's Disease. 44, 3, p. 851-857 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Elliott, C. T., Holscher, C., Johnston, J., McGuinness, B., Kehoe, P. G., Passmore, A. P. & Green, B. D., 24/03/2015, In: PLoS ONE. 10, 3, 16 p., e0119452.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease

    Hamilton, A. & Holscher, C., 17/04/2012, In: Brain Research. 1449, p. 83-93 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

    Hamilton, A., Patterson, S., Porter, D., Gault, V. A. & Hölscher, C., 04/2011, In: Journal of Neuroscience Research. 89, 4, p. 481-489 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

    Hamilton, A. & Hölscher, C., 26/08/2009, In: NeuroReport. 20, 13, p. 1161-1166 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

    Han, W-N., Hölscher, C., Yuan, L., Yang, W., Wang, X-H., Wu, M-N. & Qi, J-S., 02/2013, In: Neurobiology of Aging. 34, 2, p. 576-588 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat

    Han, L., Holscher, C., Xue, G., Li, G. & Li, D., 6/01/2016, In: NeuroReport. 27, 1, p. 23-32 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    抗糖尿病新药(D-Ser2)Oxm 拮抗淀粉样β 蛋白细胞毒性的神经保护 效应观察

    Han, Y-F., Hölscher, C., Wang, Z-J., Zhang, J., Yuan, L., Tong, J-Q., Wang, D-D., Wu, M-N. & Qi, J-S., 25/06/2016, In: Acta Physiologica Sinica. 68, 3, p. 265-275 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Potential roles of glucagon-like peptide-1 (GLP-1) in neuroprotection

    Holscher, C., 10/2012, In: CNS Drugs. 26, 10, p. 871-882 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Diabetes as a risk factor for Alzheimer’s disease: insulin signalling impairment in the brain as an alternative model of Alzheimer’s disease

    Holscher, C., 08/2011, In: Biochemical Society Transactions. 39, 4, p. 891-897 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

    Holscher, C., 1/04/2014, In: Journal of Endocrinology. 221, p. T31-T41 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects

    Holscher, C., 06/2014, In: Regulatory Peptides. 192-193, p. 55-56 2 p.

    Research output: Contribution to Journal/Magazine › Editorial › peer-review

  14. Published

    Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

    Hölscher, C., 1/04/2014, In: Biochemical Society Transactions. 42, 2, p. 593-599 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

    Hölscher, C., 02/2014, In: Alzheimer's and Dementia. 10, 1 Supplement, p. S47-54 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

    Hölscher, C., 02/2014, In: Alzheimer's and Dementia. 10, 1 Supplement, p. S33-37 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    The role of GLP-1 in neuronal activity and neurodegeneration

    Hölscher, C., 2010, In: Vitamins and Hormones. 84, p. 331-354 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease

    Hölscher, C., 06/2010, In: Recent Patents on CNS Drug Discovery. 5, 2, p. 109-117 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide analogues as novel treatments for Alzheimer's and Parkinson's disease

    Hölscher, C., 1/09/2016, In: Cardiovascular Endocrinology . 5, 3, p. 93-98 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

    Hölscher, C., 1/07/2018, In: Neuropharmacology. 136, Part B, p. 251-259 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

    Hölscher, C., De Felice, F. G., Greig, N. & Ferreira, S. T., 1/07/2018, In: Neuropharmacology. 136, Part B, p. 159 1 p.

    Research output: Contribution to Journal/Magazine › Editorial › peer-review

  22. Published

    Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology

    Holubová, M., Hrubá, L., Popelová, A., Bencze, M., Pražienková, V., Gengler, S., Kratochvílová, H., Haluzík, M., Železná, B., Kuneš, J., Hölscher, C. & Maletínská, L., 01/2019, In: Neuropharmacology. 144, p. 377-387 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

    Hunter, K. & Holscher, C., 2012, In: BMC Neuroscience. 13, p. 33-38 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study

    Jalewa, J., Joshi, A., McGinnity, T. M., Prasad, G., Wong-Lin, K. & Hölscher, C., 6/02/2014, In: PLoS ONE. 9, 2, 16 p., e88003.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

    Jalewa, J., Sharma, M. K. & Holscher, C., 10/2016, In: Journal of Neurochemistry. 139, 1, p. 55-67 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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