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Research

Professor Christian Holscher

Formerly at Lancaster University

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  1. Journal article
  2. Published

    The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease

    Duffy, A. M. & Hölscher, C., 3/01/2013, In: Neuroscience. 228, p. 294-300 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer ‘s disease

    McClean, P. L. & Holscher, C., 2013, In: Neuropharmacology. 76, Part A, p. 57-67 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Potential roles of glucagon-like peptide-1 (GLP-1) in neuroprotection

    Holscher, C., 10/2012, In: CNS Drugs. 26, 10, p. 871-882 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain

    McGovern, S. F. J., Hunter, K. & Hölscher, C., 14/09/2012, In: Brain Research. 1473, p. 204-213 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease

    Hamilton, A. & Holscher, C., 17/04/2012, In: Brain Research. 1449, p. 83-93 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

    Bomfim, T. R., Forny-Germano, L., Sathler, L. B., Brito-Moreira, J., Houzel, J-C., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., Holscher, C., Arnold, S. E., Talbot, K., Klein, W. L., Munoz, D. P., Ferreira, S. T. & De Felice, F. G., 2/04/2012, In: Journal of Clinical Investigation. 122, 4, p. 1339-1353 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

    Gengler, S., McClean, P. L., McCurtin, R., Gault, V. A. & Holscher, C., 02/2012, In: Neurobiology of Aging. 33, 2, p. 265-276 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

    Gao, C., Hölscher, C., Liu, Y. & Li, L., 02/2012, In: Reviews in the Neurosciences. 23, 1, p. 1-11 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

    Faivre, E., Hamilton, A. & Hölscher, C., 15/01/2012, In: European Journal of Pharmacology. 674, 2-3, p. 294-306 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains

    Li, L., Zhang, Z-F., Hölscher, C., Gao, C., Jiang, Y-H. & Liu, Y-Z., 15/01/2012, In: European Journal of Pharmacology. 674, 2-3, p. 280-286 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

    Hunter, K. & Holscher, C., 2012, In: BMC Neuroscience. 13, p. 33-38 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus

    Li, L., Hölscher, C., Chen, B-B., Zhang, Z-F. & Liu, Y-Z., 12/2011, In: Biological Trace Element Research. 143, 3, p. 1581-1593 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    Diabetes as a risk factor for Alzheimer’s disease: insulin signalling impairment in the brain as an alternative model of Alzheimer’s disease

    Holscher, C., 08/2011, In: Biochemical Society Transactions. 39, 4, p. 891-897 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease

    McClean, P. L., Parthsarathy, V., Faivre, E. & Holscher, C., 27/04/2011, In: Journal of Neuroscience. 31, 17, p. 6587-6594 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

    Faivre, E., Gault, V. A., Thorens, B. & Hölscher, C., 1/04/2011, In: Journal of Neurophysiology. 105, 4, p. 1574-1580 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

    Hamilton, A., Patterson, S., Porter, D., Gault, V. A. & Hölscher, C., 04/2011, In: Journal of Neuroscience Research. 89, 4, p. 481-489 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

    Porter, D. W., Irwin, N., Flatt, P. R., Hölscher, C. & Gault, V. A., 15/01/2011, In: European Journal of Pharmacology. 650, 2-3, p. 688-693 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

    Porter, D. W., Kerr, B. D., Flatt, P. R., Hölscher, C. & Gault, V. A., 10/2010, In: Diabetes, Obesity and Metabolism. 12, 10, p. 891-899 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

    Gault, V. A., Porter, W. D., Flatt, P. R. & Holscher, C., 08/2010, In: International Journal of Obesity. 34, p. 1341-1344 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease

    Hölscher, C., 06/2010, In: Recent Patents on CNS Drug Discovery. 5, 2, p. 109-117 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease

    McClean, P. L., Gault, V. A., Harriott, P. & Hölscher, C., 25/03/2010, In: European Journal of Pharmacology. 630, 1-3, p. 158-162 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Synaptic plasticity in the hippocampus of an APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice

    Gengler, S., Hamilton, A. & Holscher, C., 22/03/2010, In: PLoS ONE. 5, 3, 10 p., e9764.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    The effect of mGlu8 deficiency in animal models of psychiatric diseases

    Fendt, M., Bürki, H., Imobersteg, S., van der Putten, H., McAllister, K., Leslie, J. C., Shaw, D. & Hölscher, C., 02/2010, In: Genes, Brain and Behavior. 9, 1, p. 33-44 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    The role of GLP-1 in neuronal activity and neurodegeneration

    Hölscher, C., 2010, In: Vitamins and Hormones. 84, p. 331-354 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

    Hamilton, A. & Hölscher, C., 26/08/2009, In: NeuroReport. 20, 13, p. 1161-1166 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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