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Research

Professor Christian Holscher

Formerly at Lancaster University

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  1. 2014
  2. Published

    Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

    McClean, P. L. & Holscher, C., 11/2014, In: Neuropharmacology. 86, p. 241-258 18 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. 2015
  4. Published

    Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease

    Liu, W., Li, Y., Jalewa, J., Saunders-Wood, T., Li, L. & Hölscher, C., 2015, In: European Journal of Pharmacology. 765, p. 284-290 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's Disease and dementia with Lewy bodies

    Graham, S. F., Nasarauddin, M. B., Carey, M., McGuinness, B., Holscher, C., Kehoe, P. G., Love, S., Passmore, A. P., Elliott, C. T., Meharg, A. & Green, B. D., 2015, In: Journal of Alzheimer's Disease. 44, 3, p. 851-857 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™

    Kelly, P., McClean, P. L., Ackermann, M., Konerding, M. A., Holscher, C. & Mitchell, C. A., 02/2015, In: Microcirculation. 22, 2, p. 133-145 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Elliott, C. T., Holscher, C., Johnston, J., McGuinness, B., Kehoe, P. G., Passmore, A. P. & Green, B. D., 24/03/2015, In: PLoS ONE. 10, 3, 16 p., e0119452.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Neuroprotective effects of geniposide on Alzheimer's disease pathology

    Liu, W., Li, G., Holscher, C. & Li, L., 08/2015, In: Reviews in the Neurosciences. 26, 4, p. 371-383 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Pharmacological inhibition of CSF1R blocks microglial proliferation and prevents the progression of Alzheimer's-like pathology

    Olmos-Alonso, A., Schetters, S. T., Sri, S., Askew, K., Vargas-Caballero, M., Holscher, C., Perry, V. H. & Gomez-Nicola, D., 08/2015, In: Glia. 63, Suppl. 1, p. E346-E347 2 p.

    Research output: Contribution to Journal/Magazine › Meeting abstract › peer-review

  10. Published

    Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

    Liu, W., Jalewa, J., Sharma, M., Li, G., Li, L. & Holscher, C., 10/09/2015, In: Neuroscience. 303, p. 42-50 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model

    Zhang, Y., Chen, Y., Li, L. & Holscher, C., 15/10/2015, In: Behavioural Brain Research. 293, p. 107-113 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

    McClean, P. L., Jalewa, J. & Holscher, C., 15/10/2015, In: Behavioural Brain Research. 293, p. 96-106 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

    Chen, Y., Zhang, Y., Li, L. & Holscher, C., 5/12/2015, In: European Journal of Pharmacology. 768, p. 21-27 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. 2016
  15. Published

    Neuroprotective role of (Val8)GLP-1-Glu-PAL in an in vitro model of Parkinson’s disease

    Li, L., Liu, K., Holscher, C., Li, G. & Liu, Y-Z., 2016, In: Neural Regeneration Research. 11, 2, p. 326-331 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease

    Ji, C., Xue, G-F., Li, G., Li, D. & Holscher, C., 01/2016, In: Reviews in the Neurosciences. 27, 1, p. 61-70 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat

    Han, L., Holscher, C., Xue, G., Li, G. & Li, D., 6/01/2016, In: NeuroReport. 27, 1, p. 23-32 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer’s disease as detected by GC-MS

    Nasaruddin, M. L., Holscher, C., Kehoe, P., Graham, S. F. & Green, B., 30/01/2016, In: American Journal of Translational Research. 8, 1, p. 154-165 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome

    Pan, X., Nasaruddin, M. B., Elliott, C. T., McGuinness, B., Passmore, A. P., Kehoe, P. G., Holscher, C., McClean, P. L., Graham, S. F. & Green, B. D., 02/2016, In: Neurobiology of Aging. 38, p. 151-163 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

    Li, Y., Liu, W., Li, L. & Holscher, C., 02/2016, In: Neuropharmacology. 101, p. 255-263 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

    Ji, C., Xue, G-F., Lijun, C., Feng, P., Li, D., Li, L., Li, G. & Holscher, C., 1/03/2016, In: Brain Research. 1634, p. 1-11 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

    Olmos-Alonso, A., Schetters, S. T. T., Sri, S., Askew, K., Mancuso, R., Vargas-Caballero, M., Holscher, C., Perry, V. H. & Gomez-Nicola, D., 1/03/2016, In: Brain. 139, 3, p. 891-907 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain

    Lijun, C., Li, D., Feng, P., Li, L., Xue, G., Li, G. & Holscher, C., 13/04/2016, In: NeuroReport. 27, 6, p. 384-391 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    抗糖尿病新药(D-Ser2)Oxm 拮抗淀粉样β 蛋白细胞毒性的神经保护 效应观察

    Han, Y-F., Hölscher, C., Wang, Z-J., Zhang, J., Yuan, L., Tong, J-Q., Wang, D-D., Wu, M-N. & Qi, J-S., 25/06/2016, In: Acta Physiologica Sinica. 68, 3, p. 265-275 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide analogues as novel treatments for Alzheimer's and Parkinson's disease

    Hölscher, C., 1/09/2016, In: Cardiovascular Endocrinology . 5, 3, p. 93-98 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases

    Li, Y., Li, L. & Holscher, C., 10/2016, In: Reviews in the Neurosciences. 27, 7, p. 689-711 23 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. Published

    Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

    Jalewa, J., Sharma, M. K. & Holscher, C., 10/2016, In: Journal of Neurochemistry. 139, 1, p. 55-67 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. Published

    Therapeutic potential of genipin in central neurodegenerative diseases

    Li, Y., Li, L. & Holscher, C., 10/2016, In: CNS Drugs. 30, 10, p. 889-897 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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