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Research

Dr Christopher Gaffney

Senior Lecturer in Integrative Physiology

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  1. 2014
  2. Published

    Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases

    Muñoz-Lobato, F., Rodríguez-Palero, M. J., Naranjo-Galindo, F. J., Shephard, F., Gaffney, C. J., Szewczyk, N. J., Hamamichi, S., Caldwell, K. A., Caldwell, G. A., Link, C. D. & Miranda-Vizuete, A., 10/01/2014, In: Antioxidants and Redox Signaling. 20, 2, p. 217-235 19 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Methods to assess subcellular compartments of muscle in C. elegans

    Gaffney, C. J., Bass, J. J., Barratt, T. F. & Szewczyk, N. J., 13/11/2014, In: Journal of Visualized Experiments. 93, p. e52043

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. 2015
  5. Unpublished

    The impact of physiological stressors on mitochondrial function in Caenorhabditis elegans and in humans

    Gaffney, C. J., 2015, (Unpublished) University of Nottingham. 281 p.

    Research output: Thesis › Doctoral Thesis

  6. Published

    The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans

    Etheridge, T., Rahman, M., Gaffney, C. J., Shaw, D., Shephard, F., Magudia, J., Solomon, D. E., Milne, T., Blawzdziewicz, J., Constantin-Teodosiu, D., Greenhaff, P. L., Vanapalli, S. A. & Szewczyk, N. J., 04/2015, In: FASEB Journal. 29, 4, p. 1235-1246 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. 2016
  8. Published

    Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle

    Gaffney, C. J., Shephard, F., Chu, J., Baillie, D. L., Rose, A., Constantin-Teodosiu, D., Greenhaff, P. L. & Szewczyk, N. J., 05/2016, In: Journal of Cachexia, Sarcopenia and Muscle. 7, 2, p. 181-192 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development

    Mora-Lorca, J. A., Sáenz-Narciso, B., Gaffney, C. J., Naranjo-Galindo, F. J., Pedrajas, J. R., Guerrero-Gómez, D., Dobrzynska, A., Askjaer, P., Szewczyk, N. J., Cabello, J. & Miranda-Vizuete, A., 07/2016, In: Free Radical Biology and Medicine. 96, p. 446-461 16 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. 2017
  11. Published

    Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia

    Gaffney, C. J., Mansell, P., Stephens, F. B., Macdonald, I. A. & Tsintzas, K., 29/05/2017, In: Journal of Diabetes Research. 2017, 8 p., 8248725.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans

    Samms, R. J., Lewis, J. E., Norton, L., Stephens, F. B., Gaffney, C. J., Butterfield, T., Smith, D. P., Cheng, C. C., Perfield, J. W., Adams, A. C., Ebling, F. J. P. & Tsintzas, K., 1/10/2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 10, p. 3806-3813 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Mitochondria-targeting hydrogen sulfide donors prolong healthspan: lifespan ratio in Caenorhabditis elegans

    Etheridge, T., Gaffney, C., Szewczyk, N., Torregrossa, R., Wood, M. E. & Whiteman, M., 11/2017, In: Free Radical Biology and Medicine. 112, Suppl. 1, p. 51-51 1 p.

    Research output: Contribution to Journal/Magazine › Meeting abstract › peer-review

  14. Published

    The effect of long-term confinement and the efficacy of exercise countermeasures on muscle strength during a simulated mission to Mars: data from the Mars500 study

    Gaffney, C. J., Fomina, E., Babich, D., Kitov, V., Uskov, K. & Green, D. A., 13/11/2017, In: Sports Medicine - Open. 3, 1, 11 p., 40.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. 2018
  16. Published

    Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans

    Gaffney, C. J., Pollard, A., Barratt, T., Constantin-Teodosiu, D., Greenhaff, P. L. & Szewczyk, N., 2018, In: Aging. 10, 11, p. 3382—3396 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Worms in Space for Outreach on Earth: Space Life Science Activities for the Classroom

    Gaffney, C. J., Pollard, A., Deane, C., Cooke, M., Balsamo, M., Hewitt, J., Vanapalli, S., Szewczyk, N., Etheridge, T. & Phillips, B., 2018, In: Gravitational and Space Research. 6, 2, p. 74-82 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    C. elegans as a model for understanding spaceflight induced muscle decline

    Pollard, A., Gaffney, C., Deane, C., Cooke, M., Hewitt, J., Phillips, B., Szewczyk, N., Vanapalli, S. & Etheridge, T., 18/06/2018.

    Research output: Contribution to conference - Without ISBN/ISSN › Abstract › peer-review

  19. Published

    Worms in space: why we are launching them

    Gaffney, C. & Phillips, B., 3/12/2018, The Conversation.

    Research output: Other contribution

  20. Published

    Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs

    Hewitt, J., Pollard, A., Lesanpezeshki, L., Deane, C., Gaffney, C. J., Etheridge, T., Szewczyk, N. & Vanapalli, S., 31/12/2018, In: Disease Models & Mechanisms. 11, 11, 13 p., 36137.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. 2019
  22. Published

    Our experience with national and international outreach and engagement for #wormsinspace

    Deane, C., Gaffney, C., Etheridge, T., Szewczyk, N. & Phillips, B., 27/04/2019.

    Research output: Contribution to conference - Without ISBN/ISSN › Abstract

  23. Published

    Space Race 2.0: Hostile Space

    Gaffney, C., 8/05/2019, Down to Earth.

    Research output: Other contribution

  24. Published

    NemaLife Machine: An automated microfluidic system for whole-life studies in C. elegans

    Anupom, T., Rahman, M., Gupta, S., Edwards, H., Soni, P., LeBlanc, M., Koblah, D., Gaffney, C., Etheridge, T., Szewczyk, N., Driscoll, M. & Vanapalli, S. A., 20/06/2019.

    Research output: Contribution to conference - Without ISBN/ISSN › Poster

  25. 2020
  26. E-pub ahead of print

    Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight and obese men

    Tsintzas, K., Jones, R., Pabla, P., Mallinson, J., Barrett, D., Kim, D-H., Cooper, S., Davies, A., Taylor, T., Gaffney, C., Chee, C., van Loon, L. & Stephens, F., 7/01/2020, (E-pub ahead of print) In: American Journal of Physiology - Endocrinology and Metabolism.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. Published

    Commercial access for UK/ESA student experiments on board the ISS

    Gaffney, C., Nartallo, R., Neri, G., Zolesi, D., Torregrossa, R., Deane, C., Whiteman, M., Etheridge, T., Ellwood, R., Cooke, M., Gharahdaghi, N., Piasecki, M., Phillips, B. & Szewczyk, N., 15/04/2020, Proceedings of the 3rd Symposium on Space Educational Activities. Leicester: University of Leicester, p. 152-154 3 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper

  28. Published

    High-intensity workouts may put regular gym goers at risk of rhabdomyolysis, a rare but dangerous condition

    Gaffney, C., 17/07/2020

    Research output: Exhibits, objects and web-based outputs › Web publication/site

  29. Published

    Minimizing Muscle Atrophy

    Gaffney, C., Etheridge, T. & Szewczyk, N., 28/07/2020, Handbook of Life Support Systems for Spacecraft and Extraterrestrial Habitats. Shayler, D. J. & Seedhouse, E. (eds.). Cham: Springer, p. 1-27 27 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed) › peer-review

  30. Published

    Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments

    Pollard, A., Gaffney, C., Deane, C., Balsamo, M., Cooke, M., Ellwood, R., Hewitt, J., Mierzwa, B., Mariani, A., Vanapalli, S. A., Etheridge, T. & Szewczyk, N. J., 6/08/2020, In: Astrobiology. 20, 8, p. 935-943 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. E-pub ahead of print

    The impact of prehabilitation on patient outcomes in hepatobiliary, colorectal, and upper gastrointestinal cancer surgery: a PRISMA-accordant meta-analysis

    Lambert, J., Hayes, L., Keegan, T., Subar, D. & Gaffney, C., 12/11/2020, (E-pub ahead of print) In: Annals of Surgery. 0, p. 0-0

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  32. 2021
  33. Published

    Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer's disease

    Owens, L., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 15/02/2021, In: Brain Research. 1753, 12 p., 147264.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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