David Allsop - Publications & Outputs - Research Portal

Professor David Allsop

Formerly at Lancaster University

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2022
Published
Alzheimer's disease diagnosis by blood plasma molecular fluorescence spectroscopy (EEM)
Dos Santos, R. F., Paraskevaidi, M., Mann, D. M. A., Allsop, D., Santos, M. C. D., Morais, C. L. M. & Lima, K. M. G., 28/09/2022, In: Scientific Reports. 12, 1, 13 p., 16199.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Oxidative Stress, Cytotoxic and Inflammatory Effects of Urban Ultrafine Road-Deposited Dust from the UK and Mexico in Human Epithelial Lung (Calu-3) Cells
Hammond, J., Maher, B. A., Gonet, T., Bautista, F. & Allsop, D., 14/09/2022, In: Antioxidants. 11, 9, 18 p., 1814.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2021
Published
Amyotrophic lateral sclerosis: Correlations between fluid biomarkers of NfL, TDP-43, and tau, and clinical characteristics
Kojima, Y., Kasai, T., Noto, Y.-I., Ohmichi, T., Tatebe, H., Kitaoji, T., Tsuji, Y., Kitani-Morii, F., Shinomoto, M., Allsop, D., Teramukai, S., Mizuno, T. & Tokuda, T., 29/11/2021, In: PLoS ONE. 16, 11 , 13 p., e0260323.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Variation in the concentration and regional distribution of magnetic nanoparticles in human brains, with and without Alzheimer’s disease, from the UK
Hammond, J., Maher, B., Ahmed, I. & Allsop, D., 30/04/2021, In: Scientific Reports. 11, 13 p., 9363.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Cerebral spinal fluid biomarker profiles in CNS infection associated with HSV and VZV mimic patterns in Alzheimer’s disease
Shinomoto, M., Kasai, T., Tatebe, H., Kitani-Morii, F., Ohmichi, T., Fujino, Y., Allsop, D., Mizuno, T. & Tokuda, T., 4/01/2021, In: Translational Neurodegeneration. 10, 1, 3 p., 2.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2020
Published
Diagnostic biomarkers for Alzheimer’s disease using non‐invasive specimens
Paraskevaidi, M., Allsop, D., Karim, S., Martin, F. & Crean, S., 1/06/2020, In: Journal of Clinical Medicine. 9, 6, 19 p., 1673.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Apathy as a behavioural marker of cognitive impairment in Parkinson's disease: a longitudinal analysis
Martin, G. P., McDonald, K. R., Allsop, D., Diggle, P. J. & Leroi, I., 1/01/2020, In: Journal of Neurology. 267, 1, p. 214-227 14 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2019
Published
Combined use of CSF NfL and CSF TDP-43 improves diagnostic performance in ALS: A comprehensive analysis on diagnostic and prognostic significance of plasma and CSF NfL, TDP-43, and tau
Kasai, T., Kojima, Y., Ohmichi, T., Tatebe, H., Tsuji, Y., Noto, Y.-I., Kitani-Morii, F., Shinomoto, M., Allsop, D., Mizuno, T. & Tokuda, T., 1/12/2019, In: Annals of Clinical and Translational Neurology. 6, 12, p. 2489-2502 14 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients
Shinomoto, M., Kasai, T., Tatebe, H., Kondo, M., Ohmichi, T., Morimoto, M., Chiyonobu, T., Terada, N., Allsop, D., Yokota, I., Mizuno, T. & Tokuda, T., 5/04/2019, In: PLoS ONE. 14, 4, 13 p., e0211575.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2018
Published
Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer’s disease
Paraskevaidi, M., Morais, C., Freitas, D., Lima, K., Mann, D., Allsop, D., Martin-Hirsch, P. & Martin, F. L., 21/12/2018, In: Analyst. 143, 24, p. 5959-5964 6 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Liposome delivery systems for the treatment of Alzheimer’s disease
Ross, C., Taylor, M. N., Fullwood, N. J. & Allsop, D., 12/12/2018, In: International Journal of Nanomedicine. 2018, 13, p. 8507-8522 16 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Raman spectroscopy to diagnose Alzheimer's disease and dementia with Lewy bodies in blood
Paraskevaidi, M., Morais, C., Halliwell, D., Mann, D., Allsop, D., Martin-Hirsch, P. & Martin, F. L., 2018, In: ACS Chemical Neuroscience. 9, 11, p. 2786–2794 9 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Untangled - peptide-based inhibitors of tau aggregation as a potential treatment for Alzheimer's disease
Allsop, D., Aggidis, A., Fullwood, N. J., Taylor, M. N., Foulds, P., Vincent, S. & Dale, M., 2018, In: Journal of Prevention of Alzheimer's Disease. 5, Suppl 1, p. S15-S16 2 p.
Research output: Contribution to Journal/Magazine › Meeting abstract
2017
Published
Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes
Obasse, I. C., Taylor, M. N., Fullwood, N. J. & Allsop, D., 6/12/2017, In: Interface Focus. 7, 6, 11 p., 20160127.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Increased levels of plasma total tau in adult Down syndrome
Kasai, T., Tatebe, H., Kondo, M., Ishii, R., Ohmichi, T., Yeung, W. T. E., Morimoto, M., Chiyonobu, T., Terada, N., Allsop, D., Nakagawa, M., Mizuno, T. & Tokuda, T., 30/11/2017, In: PLoS ONE. 12, 11, 12 p., e0188802.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
A novel approach to the therapy of Alzheimer's disease based on peptide nanoliposome inhibitors of Aβ and tau aggregation
Allsop, D., Taylor, M. N., Fullwood, N. J., Michael, M., Aggidis, A., Vincent, S. & Dale, M., 1/11/2017, In: Journal of Prevention of Alzheimer's Disease. 4, 4, p. 385-386 2 p.
Research output: Contribution to Journal/Magazine › Meeting abstract › peer-review
Published
α-Synuclein interacts with lipoproteins in plasma
Nouri Emamzadeh, F. & Allsop, D., 10/2017, In: Journal of Molecular Neuroscience . 63, 2, p. 165-172 8 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Differential diagnosis of Alzheimer’s disease using spectrochemical analysis of blood
Paraskevaidi, M., Morais, C., Lima, K., Snowden, J., Saxon, J., Richardson, A., Jones, M., Mann, D., Allsop, D., Martin-Hirsch, P. & Martin, F., 19/09/2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. E7929–E7938 10 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and Down syndrome
Tatebe, H., Kasai, T., Ohmichi, T., Kishi, Y., Kakeya, T., Waragai, M., Kondo, M., Allsop, D. & Tokuda, T., 4/09/2017, In: Molecular Neurodegeneration. 12, 63, 11 p., 63.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer's disease
Kasai, T., Kondo, M., Ishii, R., Tanaka, A., Ataka, S., Shimada, H., Tomiyama, T., Mori, H., Taylor, M. N., Allsop, D., Nakagawa, M., Mizuno, T. & Tokuda, T., 10/04/2017, In: PLoS ONE. 12, 4
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives
Castelletto, V., Ryumin, P., Cramer, R., Hamley, I., Taylor, M. N., Allsop, D., Reza, M., Ruokolainen, J., Arnold, T., Hermida-Merino, D., Garcia, C. I., Leal, M. C. & Castaño, E., 8/03/2017, In: Scientific Reports. 7, 12 p., 43637.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
ß-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the ß-amyloid aggregation process preserving the monomer species
Pellegrino, S., Tonali, N., Erba, E., Kaffy, J., Taverna, M., Contini, A., Taylor, M. N., Allsop, D., Gelmi, M. L. & Ongeri, S., 1/02/2017, In: Chemical Science. 8, 2, p. 1295-1302 8 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Retro-inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer’s Aβ peptide
Gregori, M., Taylor, M. N., Salvati, E., Re, F., Mancini, S., Balducci, C., Forloni, G., Zambelli, V., Sesana, S., Michael, M., Michail, C., Kolosov, O. V., Tinker-Mill, C. L., Sherer, M., Harris, S., Fullwood, N. J., Masserini, M. & Allsop, D., 02/2017, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 2, p. 723-732 10 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2016
Published
Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
Morris, O., Gregory, J., Kadirvel, M., Henderson, F., Blykers, A., McMahon, A., Taylor, M. N., Allsop, D., Allan, S., Grigg, J., Boutin, H. & Prenant, C., 10/2016, In: Applied Radiation and Isotopes. 116, p. 120-127 8 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Magnetite pollution nanoparticles in the human brain
Maher, B. A., Ahmed, I., Karloukovski, V. V., MacLaren, D., Foulds, P., Allsop, D., Mann, D., Torres-Jardon, R. & Calderon-Garciduenas, L., 27/09/2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 39, p. 10797-10801 5 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Effects of different isoforms of apoE on aggregation of the α- synuclein protein implicated in Parkinson's disease
Nouri Emamzadeh, F., Aojula, H., McHugh, P. & Allsop, D., 8/04/2016, In: Neuroscience Letters. 618, p. 146-151 6 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Designed glycopeptidomimetics disrupt protein−protein interactions mediating amyloid β‑peptide aggregation and restore neuroblastoma cell viability
Kaffy, J., Brinet, D., Soulier, J.-L., Tonali, N., Fera, K. F., Iacone, Y., Hoffmann, A. R. F., Khemtemourian, L., Crousse, B., Taylor, M. N., Allsop, D., Taverna, M., Lequin, O. & Ongeri, S., 10/03/2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2025-2040 16 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2015
Published
A preliminary electron microscopic investigation into the interaction between Aβ1-42 peptide and a novel nanoliposome- coupled retro-inverso peptide inhibitor, developed as a potential treatment for Alzheimer's disease
Sherer, M., Fullwood, N. J., Taylor, M. & Allsop, D., 1/10/2015, In: Journal of Physics: Conference Series. 644, 1, 4 p., 012040.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2014
Published
Nanomechanical and nanothermal mapping of initial stages of amyloid fibres formation
Kolosov, O., Tovee, P., Tinker-Mill, C. & Allsop, D., 15/09/2014, p. 29. 1 p.
Research output: Contribution to conference - Without ISBN/ISSN › Abstract › peer-review
Published
Amyloid β-peptide and Alzheimer's disease
Allsop, D. & Mayes, J., 18/08/2014, In: Essays in Biochemistry. 56, p. 99-110 12 p., 7.
Research output: Contribution to Journal/Magazine › Literature review › peer-review
Published
Amyloid-β fibrils in Alzheimer's Disease are not inert when bound to copper ions but can degrade hydrogen peroxide and generate reactive oxygen species
Mayes, J., Tinker-Mill, C., Kolosov, O., Zhang, H., Tabner, B. & Allsop, D., 25/04/2014, In: Journal of Biological Chemistry. 289, p. 12052-12062 11 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Ultrasonic force microscopy for nanomechanical characterization of early and late-stage amyloid-β peptide aggregation
Tinker-Mill, C., Mayes, J., Allsop, D. & Kolosov, O., 2014, In: Scientific Reports. 4, 7 p., 4004.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2013
Published
Correlation of Aβ oligomer levels in matched cerebrospinal fluid and serum samples
Kasai, T., Tokuda, T., Taylor, M., Kondo, M., Mann, D. M. A., Foulds, P., Nakagawa, M. & Allsop, D., 13/09/2013, In: Neuroscience Letters. 551, p. 17-22 6 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson’s disease
Foulds, P., Diggle, P., Mitchell, J. D., Parker, A., Hasegawa, M., Masuda-Suzukake, M., Mann, D. M. A. & Allsop, D., 29/08/2013, In: Scientific Reports. 3, 6 p., 2540.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's Disease
Parthsarathy, V., McClean, P. L., Hölscher, C., Taylor, M., Tinker, C., Jones, G., Kolosov, O., Salvati, E., Gregori, M., Masserini, M. & Allsop, D., 2013, In: PLoS ONE. 8, 1, 11 p., e54769.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
A possible key role for redox-active metal ions and soluble oligomers in neurodegenerative diseases
Tabner, B., Moore, S., Mayes, J. & Allsop, D., 2013, Brain diseases and metalloproteins. Brown, D. R. (ed.). Boca Raton, Fla.: Pan Stanford, p. 11-32 22 p.
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
2012
Published
Utilization of a multiple antigenic peptide as a calibration standard in the BAN50 single antibody sandwich ELISA for Aß oligomers
Kasai, T., Tokuda, T., Taylor, M., Nakagawa, M. & Allsop, D., 8/06/2012, In: Biochemical and Biophysical Research Communications. 422, 3, p. 375-380 6 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies
Foulds, P., Yokota, O., Thurston, A., Davidson, Y., Ahmed, Z., Holton, J., Thompson, J. C., Akiyama, H., Arai, T., Hasegawa, M., Gerhard, A., Allsop, D. & Mann, D. M. A., 01/2012, In: Neurobiology of Disease. 45, 1, p. 188-195 8 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Nanoscale SPM characterisation of nacre aragonite plates and synthetic human amyloid fibres
Grishin, I., Tinker, C., Allsop, D., Robson, A. & Kolosov, O., 2012, NSTI-Nanotech 2012. Santa Clara, USA: CRC PRESS-TAYLOR & FRANCIS GROUP, Vol. 1. p. 110-113 4 p.
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
Published
Phosphorylated α-synuclein as a potential biomarker for Parkinson's disease (Editorial)
Foulds, P., Mann, D. & Allsop, D., 2012, In: Expert Review of Molecular Diagnostics. 12, 2, p. 115-117 3 p.
Research output: Contribution to Journal/Magazine › Editorial
2011
Published
TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's Syndrome: association with age, hippocampal sclerosis and clinical phenotype
Davidson, Y. S., Raby, S., Foulds, P., Robinson, A., Thompson, J. C., Sikkink, S., Yusuf, I., Amin, H., Duplessis, D., Troakes, C., Al-Sarraj, S., Sloan, C., Esiri, M. M., Prasher, V. P., Allsop, D., Neary, D., Pickering-Brown, S. M., Snowden, J. S. & Mann, D. M. A., 12/2011, In: Acta Neuropathologica. 122, 6, p. 703-713 11 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide
Taylor, M., Moore, S., Mourtas, S., Niarakis, A., Re, F., Zona, C., La Ferla, B., Nicotra, F., Masserini, M., Antimisiaris, S. G., Gregori, M. & Allsop, D., 10/2011, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 7, 5, p. 541-550 10 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
The amylin peptide implicated in type 2 diabetes stimulates copper-mediated carbonyl group and ascorbate radical formation
Masad, A., Tabner, B. J., Mayes, J. & Allsop, D., 15/08/2011, In: Free Radical Biology and Medicine. 51, 4, p. 869-875 7 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease
Foulds, P., Mitchell, J. D., Parker, A., Turner, R., Green, G., Diggle, P., Hasegawa, M., Taylor, M., Mann, D. & Allsop, D., 2011, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25, 12, p. 4127-4137 11 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2010
Published
Hypothesis: soluble Aβ oligomers in association with redox-active metal ions are the optimal generators of reactive oxygen species in Alzheimer's disease
Tabner, B. J., Mayes, J. & Allsop, D., 8/10/2010, In: International Journal of Alzheimer's Disease. 2011, 6 p., 546380.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Parkinson disease: progress towards a molecular biomarker for Parkinson disease
Foulds, P., Mann, D. M. A., Mitchell, J. D. & Allsop, D., 07/2010, In: Nature Reviews Neurology. 6, 7, p. 359-361 3 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease
Taylor, M., Moore, S., Mayes, J., Parkin, E., Beeg, M., Canovi, M., Gobbi, M., Mann, D. M. A. & Allsop, D., 2010, In: Biochemistry. 49, 15, p. 3261-3272 12 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
High-molecular-weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients
Fukumoto, H., Tokuda, T., Kasai, T., Ishigami, N., Hidaka, H., Kondo, M., Allsop, D. & Nakagawa, M., 2010, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24, 8, p. 2716-2726 11 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2009
Published
Galantamine inhibits β-amyloid aggregation and cytotoxicity
Matharu, B., Gibson, G., Parsons, R., Huckerby, T. N., Moore, S. A., Cooper, L. J., Millichamp, R., Allsop, D. & Austen, B., 15/05/2009, In: Journal of the Neurological Sciences. 280, 1-2, p. 49-58 10 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Detection of elevated levels of soluble α-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
Paleologou, K. E., Kragh, C. L., Mann, D. M. A., Salem, S. A., Al-Shami, R., Allsop, D., Hassan, A. H., Jensen, P. H. & El-Agnaf, O. M. A., 2009, In: Brain. 132, 4, p. 1093-1101 9 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis
Kasai, T., Tokuda, T., Ishigami, N., Sasayama, H., Foulds, P., Mitchell, D. J., Mann, D. M. A., Allsop, D. & Nakagawa, M., 2009, In: Acta Neuropathologica. 117, 1, p. 55-62 8 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration
Foulds, P., Davidson, Y., Mishra, M., Hobson, D. J., Humphreys, K. M., Taylor, M., Johnson, N., Weintraub, S., Akiyama, H., Arai, T., Hasegawa, M., Bigio, E. H., Benson, F. E., Allsop, D. & Mann, D. M. A., 2009, In: Acta Neuropathologica. 118, 5, p. 647-658 12 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2008
Published
Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's β-amyloid peptide
Austen, B. M., Paleologou, K. E., Ali, S. A. E., Qureshi, M. M., Allsop, D. & El-Agnaf, O. M. A., 2008, In: Biochemistry. 47, 7, p. 1984-1992 9 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Metal-dependent generation of reactive oxygen species from amyloid proteins implicated in neurodegenerative disease
Allsop, D., Mayes, J., Moore, S., Masad, A. & Tabner, B. J., 2008, In: Biochemical Society Transactions. 36, 6, p. 1293-1298 6 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration
Foulds, P., McAuley, E., Gibbons, L., Davidson, Y., Pickering-Brown, S. M., Neary, D., Snowden, J. S., Allsop, D. & Mann, D. M. A., 2008, In: Acta Neuropathologica. 116, 2, p. 141-146 6 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2007
Published
An investigation into the lipid-binding properties of α-, β- and γ-synucleins in human brain and cerebrospinal fluid
Salem, S. A., Allsop, D., Mann, D. M. A., Tokuda, T. & El-Agnaf, O. M. A., 19/09/2007, In: Experimental Brain Research. 1170, p. 103-111 9 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Copper-mediated formation of hydrogen peroxide from the amylin peptide: a novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?
Masad, A., Hayes, L., Tabner, B., Turnbull, S., Cooper, L., Fullwood, N. J., German, M., Kametani, F., El-Agnaf, O. M. A. & Allsop, D., 2007, In: FEBS Letters. 581, 18, p. 3489-3493 5 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2006
Published
Plasma amyloid-β concentrations in Alzheimer's disease : an alternative hypothesis.
Fullwood, N. J., Hayashi, Y. & Allsop, D., 12/2006, In: Lancet Neurology. 5, 12, p. 1000-1001 2 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.
Tokuda, T., Salem, S. A., Allsop, D., Mizuno, T., Nakagawa, M., Qureshi, M. M., Locascio, J. J., Schlossmacher, M. G. & El-Agnaf, O., 13/10/2006, In: Biochemical and Biophysical Research Communications. 349, 1, p. 162-166 5 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Donepezil for severe Alzheimer's disease.
Allsop, D., Martin, F., Moore, S. & Fullwood, N. J., 29/07/2006, In: Lancet. 368, 9533, p. 361-362 2 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on β-amyloid and α-synuclein.
Tabner, B. J., Turnbull, S., King, J., Benson, F. E., El-Agnaf, O. M. A. & Allsop, D., 07/2006, In: Free Radical Research. 40, 7, p. 731-739 9 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson’s disease
El-Agnaf, O. M. A., Salem, S. A., Paleologou, K. E., Curran, M. D., Gibson, M. J., Court, J. A., Schlossmacher, M. G. & Allsop, D., 2006, In: FASEB Journal. 20, 3, p. 419-425 7 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2005
Published
Protein aggregation, metals and oxidative stress in neurodegenerative diseases.
Tabner, B. J., El-Agnaf, O. M. A., German, M. J., Fullwood, N. J. & Allsop, D., 11/2005, In: Biochemical Society Transactions. 33, 5, p. 1082-1086 5 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer's disease and familial British dementia.
Tabner, B. J., El-Agnaf, O. M. A., Turnbull, S., German, M. J., Paleologou, K. E., Hayashi, Y., Cooper, L. J., Fullwood, N. & Allsop, D., 28/10/2005, In: Journal of Biological Chemistry. 280, 43, p. 35789-35792 4 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?
Tabner, B., Turnbull, S., Fullwood, N. J., German, M. & Allsop, D., 08/2005, In: Biochemical Society Transactions. 33, 4, p. 548-550 3 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2004
Published
A strategy for designing inhibitors of α-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.
El-Agnaf, O. M. A., Paleologou, K. E., Greer, B., Abogrein, A. M., King, J., Salem, S. A., Fullwood, N. J., Benson, F. E., Hewitt, R., Ford, K. J., Martin, F., Harriott, P., Cookson, M. R. & Allsop, D., 08/2004, In: FASEB Journal. 18, 11, p. 1315-1317 3 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Both the D-(+) and L-(-) enantiomers of nicotine inhibit Aβ aggregation and cytotoxicity.
Moore, S. A., Huckerby, T. N., Gibson, G. L., Fullwood, N. J., Turnbull, I., Tabner, B. J., El-Agnaf, O. M. A. & Allsop, D., 01/2004, In: Biochemistry. 43, 3, p. 819-826 8 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Induction of cellular oxidative stress by the β-amyloid peptide involved in Alzheimer's disease.
Gibson, G. L., Allsop, D. & Austen, B. M., 2004, In: Protein and Peptide Letters. 11, 3, p. 257-270 14 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
α-Synuclein and the pathogenesis of Parkinson’s disease.
Martin, F., Allsop, D., Williamson, S. J. M., Paleologou, K. E. & El-Agnaf, O. M. A., 2004, In: Protein and Peptide Letters. 11, 3, p. 229-237 9 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2003
Published
Fe(II)-induced DNA damage in α-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay.
Martin, F., Williamson, S. J. M., Paleologou, K. E., Hewitt, R., El-Agnaf, O. M. A. & Allsop, D., 11/2003, In: Journal of Neurochemistry. 87, 3, p. 620-630 11 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
α-Synuclein implicated in Parkinson’s disease is present in extracellular biological fluids, including human plasma.
El-Agnaf, O. M. A., Salem, S. A., Paleologou, K. E., Cooper, L. J., Fullwood, N. J., Gibson, M. J., Curran, M. D., Court, J. A., Mann, D. M. A., Ikeda, S.-I., Cookson, M. R., Hardy, J. & Allsop, D., 10/2003, In: FASEB Journal. 17, 13, p. 1945-1947 3 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Quinacrine acts as an antioxidant and reduces the toxicity of the prion peptide PrP106-126.
Turnbull, S., Tabner, B. J., Brown, D. R. & Allsop, D., 15/09/2003, In: NeuroReport. 14, 13, p. 1743-1745 3 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Soluble oligomers for the diagnosis of neurodegenerative diseases.
El-Agnaf, O. M. A., Walsh, D. M. & Allsop, D., 08/2003, In: Lancet Neurology. 2, 8, p. 461-462 2 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Generation of hydrogen peroxide from mutant forms of the prion protein fragment PrP121-231.
Turnbull, S., Tabner, B. J., Brown, D. R. & Allsop, D., 1/07/2003, In: Biochemistry. 42, 25, p. 7675-7681 7 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Copper-dependent generation of hydrogen peroxide from the toxic prion protein fragment PrP106-126.
Turnbull, S., Tabner, B. J., Brown, D. R. & Allsop, D., 23/01/2003, In: Neuroscience Letters. 336, 3, p. 159-162 4 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Direct production of reactive oxygen species from aggregating proteins and peptides implicated in the pathogenesis of neurodegenerative diseases.
Tabner, B. J., Turnbull, S., El-Agnaf, O. M. A. & Allsop, D., 2003, In: Current Medicinal Chemistry Immunology Endocrine and Metabolic Agents. 3, 4, p. 299-308 10 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2002
Published
Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease.
Tabner, B. J., Turnbull, S., El-Agnaf, O. M. A. & Allsop, D., 1/06/2002, In: Free Radical Biology and Medicine. 32, 11, p. 1076-1083 8 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Inherited frontotemporal dementia in 9 British families associated with intronic mutations in the tau gene.
Pickering-Brown, S. M., Richardson, A. M. T., Snowden, J. S., McDonagh, A., Burns, A., Braudie, W., Baker, M., Yen, S.-H., Hardy, J., Hutton, M., Davies, Y., Allsop, D., Craufurd, D., Neary, D. & Mann, D. M. A., 04/2002, In: Brain. 125, 4, p. 732-751 20 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
2001
Published
Fluorescence anisotropy: a method for early detection of Alzheimer β-peptide (Aβ) aggregation.
Allsop, D., Swanson, L., Moore, S., Davies, Y., York, A., El-Agnaf, O. M. A. & Soutar, I., 6/07/2001, In: Biochemical and Biophysical Research Communications. 285, 1, p. 58-63 6 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
New evidence that the Alzheimer β-amyloid peptide does not spontaneously form free radicals: An ESR study using a series of spin-traps.
Turnbull, S., Tabner, B. J., El-Agnaf, O. M. A., Twyman, L. J. & Allsop, D., 15/05/2001, In: Free Radical Biology and Medicine. 30, 10, p. 1154-1162 9 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
α-synuclein implicated in Parkinson’s disease catalyses the formation of hydrogen peroxide in vitro.
Turnbull, S., Tabner, B. J., Moore, S., Davies, Y., El-Agnaf, O. M. A. & Allsop, D., 15/05/2001, In: Free Radical Biology and Medicine. 30, 10, p. 1163-1170 8 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide.
Allsop, D., Gibson, G., Martin, I. K., Moore, S., Turnbull, S. & Twyman, L. J., 01/2001, In: Bioorganic and Medicinal Chemistry Letters. 11, 2, p. 255-257 3 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.
Tabner, B. J., Turnbull, S., El-Agnaf, O. M. A. & Allsop, D., 2001, In: Current Topics in Medicinal Chemistry. 1, p. 483-493 11 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
The biology and molecular neuropathology of β-amyloid protein.
Howlett, D. R., Allsop, D. & Karran, E. H., 2001, Neurobiology of Alzheimer's disease . Dawbarn, D. & Allen, S. J. (eds.). 2nd ed. ed. Oxford: Oxford University Press, p. 75-102 28 p.
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
2000
Published
Pick's disease is associated with mutations in the tau gene.
Pickering-Brown, S., Baker, M., Yen, S.-H., Liu, W.-K., Hasegawa, M., Cairns, N., Lantos, P. L., Rossor, M., Iwatsubo, T., Davies, Y., Allsop, D., Furlong, R., Owen, F., Hardy, J., David Mann, D. & Hutton, M., 12/2000, In: Annals of Neurology. 48, 6, p. 589-867 279 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Characterisation of peptidyl boronic acid inhibitors of mammalian 20S and 26S proteasomes and their inhibition of proteasomes in cultured cells
Gardner, R. C., Assinder, S. J., Christie, G., Mason, G. G. F., Markwell, R., Wadsworth, H., McLaughlin, M., King, R., Chabot-Fletcher, M. C., Breton, J., Allsop, D. & Rivett, A. J., 2000, In: Biochemical Journal. 346, p. 447-454 8 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Introduction to Alzheimer's disease.
Allsop, D., 2000, Alzheimer's disease : methods and protocols. Hooper, N. (ed.). Totawa, New Jersey: Humana Press, p. 1-21 21 p.
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
Published
Modulation of β-amyloid production and fibrillisation
Allsop, D., Twyman, L., Davies, Y., Moore, S., York, A., Swanson, L. & Soutar, I., 2000, In: Biochemical Society Symposia. 67, p. 1-14 14 p.
Research output: Contribution to Journal/Magazine › Literature review › peer-review
1999
Published
A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran.
Twyman, L. J. & Allsop, D., 12/1999, In: Tetrahedron Letters. 40, 52, p. 9383-9384 2 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Alzheimer's Disease: correlation of the suppression of β-Amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome
Christie, G., Markwell, R. E., Gray, C. W., Smith, L., Godfrey, F., Mansfield, F., Wadsworth, H., King, R., McLaughlin, M., Cooper, D. G., Ward, R. V., Howlett, D. R., Hartmann, T., Lichtenthaler, S. F., Beyreuther, K., Underwood, J., Gribble, S. K., Cappai, R., Masters, C. L. & Tamaoka, A. & 4 others, Gardner, R. L., Rivett, A. J., Karran, E. H. & Allsop, D., 07/1999, In: Journal of Neurochemistry. 73, 1, p. 195-204 10 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Biological activity associated with a high molecular weight form of β-amyloid.
Howlett, D. R., Ward, R. V., Bresciani, L., Jennings, K. H., Christie, G., Allsop, D., Gray, C. W. & Karran, E. H., 1999, In: Alzheimer's Reports. 2, p. 171-177 7 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Characterization of an α-secretase candidate from human brain using a new western blot assay
Evin, G., Reed, G., Tanner, J. E., Li, Q. X., Culvenor, J. G., Fuller, S. J., Wadsworth, H., Allsop, D., Ward, R. V., Karran, E. H., Gray, C. W., Hartmann, T., Lichtenthaler, S. F., Weidemann, A., Beyreuther, K. & Masters, C. L., 1999, Alzheimer's disease and related disorders. Iqbal, K., Swaab, D. F., Winblad, B. & Wisniewski, H. M. (eds.). Wiley, p. 411-418 8 p.
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
1998
Published
Fibrillogenesis of β-amyloid
Allsop, D., Howlett, D., Christie, G. & Karran, E., 08/1998, In: Biochemical Society Transactions. 26, 3, p. 459-463 5 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Presenilins: in search of functionality
Karran, E. H., Allsop, D., Christie, G., Davis, J., Gray, C., Mansfield, F. & Ward, R. V., 08/1998, In: Biochemical Society Transactions. 26, 3, p. 491-496 6 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
1997
Published
Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides
Hartmann, T., Bieger, S. C., Brühl, B., Tienari, P. J., Ida, N., Allsop, D., Roberts, G. W., Masters, C. L., Dotti, C. G., Unsicker, K. & Beyreuther, K., 09/1997, In: Nature Medicine. 3, 9, p. 1016-1020 5 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Studies on inhibition of β-amyloid formation in APP-751-transfected IMR-32 cells, and SPA4CT-transfected SHSY5Y cells
Allsop, D., Christie, G., Gray, C., Holmes, S., Markwell, R., Owen, D., Smith, L., Wadsworth, H., Ward, R. V., Hartmann, T., Lichtenthaler, S. F., Evin, G., Fuller, S., Tanner, J., Masters, C. L., Beyreuther, K. & Roberts, G. W., 1997, Alzheimer's disease: biology, diagnosis and therapeutics. Iqbal, K., Winblad, B., Nishimura, T., Takeda, M. & Wisniewski, H. M. (eds.). New York: Wiley, p. 717-727 11 p.
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
1996
Published
Effect of aluminium on expression and processing of amyloid precursor protein
Neill, D., Leake, A., Hughes, D., Keith, A. B., Taylor, G. A., Allsop, D., Rima, B. K., Morris, C., Candy, J. M. & Edwardson, J. A., 15/11/1996, In: Journal of Neuroscience Research. 46, 4, p. 395-403 9 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Aggregation and metal-binding properties of mutant forms of the amyloid Aβ peptide of Alzheimer's disease
Clements, A., Allsop, D., Walsh, D. M. & Williams, C. H., 02/1996, In: Journal of Neurochemistry. 66, 2, p. 740-747 8 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Mechanism of cerebral amyloidosis in Alzheimer's disease
Howlett, D. R., James, S., Allsop, D. & Roberts, G. W., 1996, Neurobiology of Alzheimer's disease. Dawbarn, D. & Allen, S. J. (eds.). Oxford: BIOS Scientific Publishers, p. 46-59 14 p.
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
1995
Published
The immunoreactive profile at the N-terminal region of Aβ1-39/40 but not Aβ1-42 changes with transition from monomer/dimer to further peptide aggregates
Kametani, F., Tanaka, K., Tokuda, T. & Allsop, D., 12/12/1995, In: Brain Research. 703, 1-2, p. 237-241 5 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Professor David Allsop

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