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Professor David Middleton

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  1. 2023
  2. Published

    Solid-state NMR chemical shift analysis for determining the conformation of ATP bound to Na,K-ATPase in its native membrane †

    Middleton, D. A., Griffin, J., Esmann, M. & Fedosova, N. U., 29/11/2023, In: RSC Advances. 13, 49, p. 34836-34846 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization

    Whitehead, M., Yusoff, S., Ahmad, S., Schmidt, L., Mayr, M., Madine, J., Middleton, D. & Shanahan, C., 28/02/2023, In: Aging Cell. 22, 2, 19 p., e13746.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. 2022
  5. Forthcoming

    Analysis of the orientation of cholesterol in high-density lipoprotein nanodiscs using solid-state NMR

    Lau, S. & Middleton, D., 7/09/2022, (Accepted/In press) In: Physical Chemistry Chemical Physics.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. 2021
  7. Published

    19F Solid-State NMR and Vibrational Raman Characterization of Corticosteroid Drug-Lipid Membrane Interactions

    Mapley, B., Townsend, D., Griffin, J., Ashton, L. & Middleton, D., 15/11/2021, In: ChemPlusChem. 86, 11, p. 1517-1523 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. 2020
  9. Published

    Raman Spectroscopy with 2D Perturbation Correlation Moving Windows for the Characterization of Heparin–Amyloid Interactions

    Townsend, D., Middleton, D. & Ashton, L., 31/10/2020, In: Analytical Chemistry. 92, 20, p. 13822–13828 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Sensitive morphological characterization of oriented high‐density lipoprotein nanoparticles using 31P NMR spectroscopy

    Lau, S. & Middleton, D., 5/10/2020, In: Angewandte Chemie International Edition. 59, 41, p. 18126-18130 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. E-pub ahead of print

    Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin

    Townsend, D., Fullwood, N., Yates, E. & Middleton, D., 21/09/2020, (E-pub ahead of print) In: Biochemistry.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. E-pub ahead of print

    Circular dichroism spectroscopy identifies the β-adrenoceptor agonist salbutamol as a direct inhibitor of tau filament formation in vitro.

    Middleton, D., Townsend, D., Hughes, E., Fullwood, N., Siligardi, G., Hussain, R. & Mala, B., 10/06/2020, (E-pub ahead of print) In: ACS Chemical Neuroscience.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. 2019
  14. Published

    Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR

    Lau, S., Griffin, J., Hughes, E. & Middleton, D., 14/11/2019, In: Chemical Communications. 55, 88, p. 13287-13290 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. 2018
  16. Published

    Orientation of a Diagnostic Ligand Bound to Macroscopically Aligned Amyloid-β Fibrils Determined by Solid-State NMR

    Townsend, D. J., Hughes, E., Stewart, K., Griffin, J. M., Radford, S. & Middleton, D. A., 15/11/2018, In: The Journal of Physical Chemistry Letters. 9, 22, p. 6611–6615 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin

    Townsend, D., Hughes, E., Akien, G., Stewart, K. L., Radford, S. E., Rochester, D. & Middleton, D. A., 17/08/2018, In: Journal of Biological Chemistry. 293, 33, p. 12877-12893 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Average orientation of a fluoroaromatic molecule in lipid bilayers from DFT-informed NMR measurements of 1H-19F dipolar couplings

    Hughes, E., Griffin, J. M., Coogan, M. P. & Middleton, D. A., 21/07/2018, In: Physical Chemistry Chemical Physics. 20, 27, p. 18207-18215 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. 2017
  20. Published

    Molecular Origins of the Compatibility Between Glycosaminoglycans and Aβ40 Amyloid Fibrils

    Stewart, K. L., Hughes, E., Yates, E. A., Middleton, D. A. & Radford, S. E., 4/08/2017, In: Journal of Molecular Biology. 429, 16, p. 2449-2462 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Heparin and methionine oxidation promote the formation of apolipoprotein A-I amyloid comprising α-helical and β-sheet structures.

    Townsend, D. J., Hughes, E., Hussain, R., Siligardi, G., Baldock, S. J., Madine, J. & Middleton, D. A., 21/03/2017, In: Biochemistry. 56, 11, p. 1632-1644 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. 2016
  23. Published

    Atomic details of the interactions of Glycosaminoglycans with amyloid-β fibrils

    Stewart, K., Hughes, E., Yates, E., Akien, G. R., Huang, T-Y., Lima, M., Rudd, T., Guerrini, M., Hung, S-C., Radford, S. & Middleton, D. A., 13/07/2016, In: Journal of the American Chemical Society. 138, 27, p. 8328-8331 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Novel stereoselective bufadienolides reveal new insights into the requirements for Na+, K+-ATPase inhibition by cardiotonic steroids

    Tang, H-J., Ruan, L-J., Tian, H-Y., Liang, G-P., Ye, W-C., Hughes, E., Esmann, M., Fedosova, N. U., Chung, T-Y., Tzen, J. T. C., Jiang, R-W. & Middleton, D. A., 5/07/2016, In: Scientific Reports. 2016, 6, 10 p., 29155.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. 2015
  26. Published

    Long-range effects of Na+ binding in Na,K-ATPase reported by ATP

    Middleton, D. A., Fedosova, N. U. & Esmann, M., 1/12/2015, In: Biochemistry. 54, 47, p. 7041-7047 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. Published

    Comparisons with amyloid-β reveal an aspartate residue that stabilizes fibrils of the aortic amyloid peptide medin

    Davies, H., Madine, J. & Middleton, D., 20/03/2015, In: Journal of Biological Chemistry. 290, p. 7791-7803 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. Published

    Ligand orientation in a membrane-embedded receptor site revealed by solid-state NMR with paramagnetic relaxation enhancement.

    Whittaker, C., Patching, S., Esmann, M. & Middleton, D., 7/03/2015, In: Organic and Biomolecular Chemistry . 13, 9, p. 2664-2668 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  29. 2014
  30. Published

    Comparison of the structure and function of phospholamban and the Arginine-14 deficient mutant associated with dilated cardiomyopathy

    Hughes, E. & Middleton, D. A., 16/09/2014, In: PLoS ONE. 9, 9, 10 p., 106746.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. Published

    Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells

    Yuan, X-F., Tian, H-Y., Li, J., Jin, L., Jiang, S-T., Liu, K. W-K., Luo, C., Middleton, D. A., Esmann, M., Ye, W-C. & Jiang, R-W., 3/06/2014, In: Natural Product Research. 28, 11, p. 843-847 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  32. Published

    Expression and purification of the aortic amyloid polypeptide medin

    Davies, H. A., Wilkinson, M. C., Gibson, R. P. & Middleton, D. A., 06/2014, In: Protein Expression and Purification. 98, p. 32-37 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. Published

    Structures, chemotaxonomic significance, cytotoxic and Na+, K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica

    Zhang, R-R., Tian, H-Y., Tan, Y-F., Chung, T-Y., Sun, X-H., Xia, X., Ye, W-C., Middleton, D. A., Fedosova, N., Esmann, M., Tzen, J. T. C. & Jiang, R-W., 2014, In: Organic and Biomolecular Chemistry . 12, 44, p. 8919-8929 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  34. 2013
  35. Published

    Heparin promotes the rapid fibrillization of a peptide with low intrinsic amyloidogenicity

    Madine, J., Davies, H. A., Hughes, E. & Middleton, D. A., 17/12/2013, In: Biochemistry. 52, 50, p. 8984-8992 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  36. Published

    Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample

    Middleton, D. A., Madine, J., Castelletto, V. & Hamley, I. W., 27/09/2013, In: Angewandte Chemie International Edition. 52, 40, p. 10537-10540

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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