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Research

Dr Edward Parkin

Senior Lecturer in Biomedicine

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  1. Published

    A Point Mutation in the Juxtamembrane Stalk of Human Angiotensin I-converting Enzyme Invokes the Action of a Distinct Secretase.

    Alfalah, M., Parkin, E. T., Jacob, R., Sturrock, E. D., Mentele, R., Turner, A. J., Hooper, N. M. & Naim, H. Y., 15/06/2001, In: Journal of Biological Chemistry. 276, 24, p. 21105-21109 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.

    Allinson, T. M. J., Parkin, E. T., Condon, T. P., Schwager, S. L. U., Sturrock, E. D., Turner, A. J. & Hooper, N. M., 06/2004, In: European Journal of Biochemistry. 271, 12, p. 2539-2547 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    ADAMs family members as amyloid precursor protein -secretases.

    Allinson, T. M. J., Parkin, E. T., Turner, A. J. & Hooper, N. M., 1/11/2003, In: Journal of Neuroscience Research. 74, 3, p. 342-352 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. E-pub ahead of print

    Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease

    Armstrong, P., Güngör, H., Anongjanya, P., Tweedy, C., Parkin, E., Johnston, J., Carr, I. M., Dawson, N. & Clapcote, S. J., 23/03/2024, (E-pub ahead of print) In: Neuropsychopharmacology.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Pyruvate dehydrogenase kinase inhibition: reversing the Warburg effect in cancer therapy

    Bell, H. & Parkin, E. T., 23/06/2016, In: International Journal of Cancer Therapy and Oncology. 4, 2, p. 4215-4227 12 p.

    Research output: Contribution to Journal/Magazine › Literature review › peer-review

  6. Published

    Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1

    Delury, C., Tinker, C., Rivers, S., Hodges, M., Broughton, S. & Parkin, E., 2/08/2013, In: International Journal of Biochemistry Research and Review. 3, 4, p. 278-290 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration: disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling

    Delury, C. P., Hart, C., Brown, M., Clarke, N. & Parkin, E. T., 25/03/2016, In: Biochemical and Biophysical Research Communications. 472, 1, p. 255-261 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease

    Gough, M., Parr-Sturgess, C. & Parkin, E., 2011, In: Biochemistry Research International. 2011, 13 p., 721463.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

    Gough, M., Blanthorn-Hazell, S., Delury, C. & Parkin, E., 31/10/2014, In: Biochemical and Biophysical Research Communications. 453, 4, p. 741-747 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease

    Gough, M., Blanthorn-Hazell, S. & Parkin, E. T., 2015, In: Journal of Alzheimer's Disease. 43, 4, p. 1163-1168 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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