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Research

Dr Edward Parkin

Senior Lecturer in Biomedicine

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  1. Published

    A Point Mutation in the Juxtamembrane Stalk of Human Angiotensin I-converting Enzyme Invokes the Action of a Distinct Secretase.

    Alfalah, M., Parkin, E. T., Jacob, R., Sturrock, E. D., Mentele, R., Turner, A. J., Hooper, N. M. & Naim, H. Y., 15/06/2001, In: Journal of Biological Chemistry. 276, 24, p. 21105-21109 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.

    Allinson, T. M. J., Parkin, E. T., Condon, T. P., Schwager, S. L. U., Sturrock, E. D., Turner, A. J. & Hooper, N. M., 06/2004, In: European Journal of Biochemistry. 271, 12, p. 2539-2547 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    ADAMs family members as amyloid precursor protein -secretases.

    Allinson, T. M. J., Parkin, E. T., Turner, A. J. & Hooper, N. M., 1/11/2003, In: Journal of Neuroscience Research. 74, 3, p. 342-352 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. E-pub ahead of print

    Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease

    Armstrong, P., Güngör, H., Anongjanya, P., Tweedy, C., Parkin, E., Johnston, J., Carr, I. M., Dawson, N. & Clapcote, S. J., 23/03/2024, (E-pub ahead of print) In: Neuropsychopharmacology.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Pyruvate dehydrogenase kinase inhibition: reversing the Warburg effect in cancer therapy

    Bell, H. & Parkin, E. T., 23/06/2016, In: International Journal of Cancer Therapy and Oncology. 4, 2, p. 4215-4227 12 p.

    Research output: Contribution to Journal/Magazine › Literature review › peer-review

  6. Published

    Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1

    Delury, C., Tinker, C., Rivers, S., Hodges, M., Broughton, S. & Parkin, E., 2/08/2013, In: International Journal of Biochemistry Research and Review. 3, 4, p. 278-290 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration: disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling

    Delury, C. P., Hart, C., Brown, M., Clarke, N. & Parkin, E. T., 25/03/2016, In: Biochemical and Biophysical Research Communications. 472, 1, p. 255-261 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease

    Gough, M., Parr-Sturgess, C. & Parkin, E., 2011, In: Biochemistry Research International. 2011, 13 p., 721463.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

    Gough, M., Blanthorn-Hazell, S., Delury, C. & Parkin, E., 31/10/2014, In: Biochemical and Biophysical Research Communications. 453, 4, p. 741-747 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease

    Gough, M., Blanthorn-Hazell, S. & Parkin, E. T., 2015, In: Journal of Alzheimer's Disease. 43, 4, p. 1163-1168 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    The E1 copper binding domain of full-length amyloid precursor protein promotes epithelial to mesenchymal transition in DU145 cells in isoform-specific manner

    Gough, M., Delury, C. & Parkin, E., 2015, In: International Journal of Biochemistry Research and Review. 6, 1, p. 264-273 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein

    Harris, B., Pereira, I. & Parkin, E., 16/10/2009, In: Brain Research. 1296, n/a, p. 203-215 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines

    Hicks, D. A., Makova, N. Z., Gough, M., Parkin, E. T., Nalivaeva, N. N. & Turner, A. J., 6/09/2013, In: Journal of Biological Chemistry. 288, 36, p. 26039-26051 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    The role of proteolysis in Alzheimer's disease.

    Hooper, N. M., Trew, A. J., Parkin, E. T. & Turner, A. J., 2000, Cellular peptidases in immune functions and diseases. Langner, J. & Ansorge, S. (eds.). Plenum, p. 379-390 12 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter

  15. Published

    Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders.

    Isaac, R. E., Parkin, E. T., Keen, J. N., Nässel, D. R., Siviter, R. J. & Shirras, A. D., 04/2002, In: Peptides. 23, 4, p. 725-733 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2).

    Lambert, D. W., Yarski, M., Warner, F. J., Thornhill, P., Parkin, E. T., Smith, A. I., Hooper, N. M. & Turner, A. J., 26/08/2005, In: Journal of Biological Chemistry. 280, 34, p. 30113-30119 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Angiotensin-converting enzyme as a GPlase : a critical reevaluation.

    Leisle, L., Parkin, E. T., Turner, A. J. & Hooper, N. M., 11/2005, In: Nature Medicine. 11, 11, p. 1139-1140 2 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Notch Signalling as a Therapeutic Target in Cancer

    Martinas, I. & Parkin, E. T., 10/2016, In: International Journal of Cancer Therapy and Oncology. 4, 4

    Research output: Contribution to Journal/Magazine › Literature review › peer-review

  19. Published

    Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer's disease

    Owens, L., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 15/02/2021, In: Brain Research. 1753, 12 p., 147264.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    BACE1 Overexpression Reduces SH-SY5Y Cell Viability Through a Mechanism Distinct from Amyloid-β Peptide Accumulation: Beta Prime-Mediated Competitive Depletion of sAβPPα

    Owens, L., Bracewell, J., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 5/04/2022, In: Journal of Alzheimer's Disease. 86, 3, p. 1201-1220 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Osteonectin as a screening marker for pancreatic cancer: A prospective study

    Papapanagiotou, A., Sgourakis, G., Karkoulias, K., Raptis, D., Parkin, E. T., Brotzakis, P., Panchal, S. & Papavassiliou, A., 1/07/2018, In: Journal of International Medical Research. 46, 7, p. 2769-2779 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Cellular pion protein regulates beta-secretase cleavage of the Alzheimers amyloid precurs protein.

    Parkin, E., Watt, N. T., Hussain, I., Eckman, E. A., Eckman, C. B., Manson, J. C., Baybutt, H. N., Turner, A. J. & Hooper, N. M., 26/06/2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 26, p. 11062-11067 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Dual Mechanisms for Shedding of the Cellular Prion Protein.

    Parkin, E. T., Watt, N. T., Turner, A. J. & Hooper, N. M., 19/03/2004, In: Journal of Biological Chemistry. 279, 12, p. 11170-11178 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts.

    Parkin, E. T., Tan, F., Skidgel, R. A., Turner, A. J. & Hooper, N. M., 1/08/2003, In: Journal of Cell Science. 116, 15, p. 3079-3087 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    Structure-Activity Relationship of Hydroxamate-Based Inhibitors on the Secretases that Cleave the Amyloid Precursor Protein, Angiotensin Converting Enzyme, CD23, and Pro-Tumor Necrosis Factor.

    Parkin, E. T., Trew, A., Christie, G., Faller, A., Mayer, R., Turner, A. J. & Hooper, N. M., 16/04/2002, In: Biochemistry. 41, 15, p. 4972-4981 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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