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Professor Joanne Knight

Chair in Applied Data Science, Reader in Applied Data Science

  1. Published

    Biological insights from 108 schizophrenia-associated genetic loci

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 24/07/2014, In: Nature. 511, 7510, p. 421-427 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  2. Published

    Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

    CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium, 01/2017, In: Nature Genetics. 49, p. 27-35 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

    Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium, 14/06/2018, In: Cell. 173, 7, p. 1705-1715.e16 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

    Schizophrenia Working Group of the Psychiatric Genomics Consortium & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, 20/06/2017, In: Translational Psychiatry. 7, 6, 9 p., e1155.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

    UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium, Rhodes, C. J., Batai, K., Bleda, M., Haimel, M., Southgate, L., Germain, M., Pauciulo, M. W., Hadinnapola, C., Aman, J., Girerd, B., Arora, A., Knight, J., Hanscombe, K. B., Karnes, J. H., Kaakinen, M., Gall, H., Ulrich, A. & 33 others, Harbaum, L., Cebola, I., Ferrer, J., Lutz, K., Swietlik, E. M., Ahmad, F., Amouyel, P., Archer, S. L., Argula, R., Austin, E. D., Badesch, D., Bakshi, S., Barnett, C., Benza, R., Bhatt, N., Bogaard, H. J., Burger, C. D., Chakinala, M., Church, C., Coghlan, J. G., Condliffe, R., Corris, P. A., Danesino, C., Debette, S., Elliott, C. G., Elwing, J., Eyries, M., Fortin, T., Franke, A., Frantz, R. P., Frost, A., Garcia, J. G. N. & Ghio, S., 1/03/2019, In: Lancet Respiratory Medicine. 7, 3, p. 227-238 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

    CommonMind Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & iPSYCH-GEMS Schizophrenia Working Group, 1/04/2019, In: Nature Genetics. 51, 4, p. 659-674 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

    M.R.C.Psych & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 1/08/2019, In: American Journal of Psychiatry. 176, 8, p. 651-660 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia

    Schizophrenia Working Group of the Psychiatric Genomics Consortium 2, 1/08/2019, In: Neuropsychopharmacology. 44, 9, p. 1562-1569 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

    Wellcome Trust Case Control Consortium 2 & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 1/04/2019, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 180, 3, p. 223-231 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia

    GROUP Investigators & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 1/03/2020, In: Schizophrenia Bulletin. 46, 2, p. 336-344 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    A polygenic resilience score moderates the genetic risk for schizophrenia

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 6/09/2019, In: Molecular Psychiatry. 2019, 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu, 12/12/2019, In: Cell. 179, 7, p. 1469-1482.e11 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Comparative genetic architectures of schizophrenia in East Asian and European populations

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 31/12/2019, In: Nature Genetics. 51, 12, p. 1670-1678 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

    ADHD Working Group of the Psychiatric Genomics Consortium, 18/12/2019, In: Nature Communications. 10, 1, 12 p., 5765.

    Research output: Contribution to journalJournal articlepeer-review

  15. E-pub ahead of print

    Complement genes contribute sex-biased vulnerability in diverse disorders

    Schizophrenia Working Group of the Psychiatric Genomics Consortium 2, 11/05/2020, In: Nature. 28 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Attention-Deficit Hyperactivity Disorder in the post-genomic era

    Asherson, P., Knight, J. & IMAGE Consortium, 07/2004, In: European Child and Adolescent Psychiatry. 13 , Suppl 1, p. I50-70 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders

    Beall, C. M., Cavalleri, G. L., Deng, L., Elston, R. C., Gao, Y., Knight, J., Li, C., Li, J. C., Liang, Y., McCormack, M., Montgomery, H. E., Pan, H., Robbins, P. A., Shianna, K. V., Tam, S. C., Tsering, N., Veeramah, K. R., Wang, W., Wangdui, P., Weale, M. E. & 9 others, Xu, Y., Xu, Z., Yang, L., Zaman, M. J., Zeng, C., Zhang, L., Zhang, X., Zhaxi, P. & Zheng, Y. T., 22/06/2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11459-11464 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2016, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 171B, 2, p. 276-89 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Routinely collected patient data in neurology research: a systematic mapping review

    Biggin, F., Emsley, H. & Knight, J., 27/11/2020, In: BMC Neurology. 20, 9 p., 431.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Variation in waiting times by diagnostic category: an observational study of 1,951 referrals to a neurology outpatient clinic

    Biggin, F., Howcroft, T., Davies, Q., Knight, J. & Emsley, H., 31/05/2021, In: BMJ Neurology Open. 3, 1, 8 p., 000133.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    A genome-wide significant linkage for severe depression on chromosome 3: the depression network study

    Breen, G., Webb, B. T., Butler, A. W., van den Oord, E. J. C. G., Tozzi, F., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M. J., Cohen-Woods, S., Perry, J., Galwey, N. W., Upmanyu, R., Craig, I., Lewis, C. M., Ng, M., Brewster, S. & 8 others, Preisig, M., Rietschel, M., Jones, L., Knight, J., Rice, J., Muglia, P., Farmer, A. E. & McGuffin, P., 08/2011, In: American Journal of Psychiatry. 168, 8, p. 840-847 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes

    Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., Anney, R., Franke, B., Gill, M., Ebstein, R., Buitelaar, J., Sham, P., Campbell, D., Knight, J., Andreou, P., Altink, M., Arnold, R., Boer, F., Buschgens, C., Butler, L. & 42 others, Christiansen, H., Feldman, L., Fleischman, K., Fliers, E., Howe-Forbes, R., Goldfarb, A., Heise, A., Gabriëls, I., Korn-Lubetzki, I., Johansson, L., Marco, R., Medad, S., Minderaa, R., Mulas, F., Müller, U., Mulligan, A., Rabin, K., Rommelse, N., Sethna, V., Sorohan, J., Uebel, H., Psychogiou, L., Weeks, A., Barrett, R., Craig, I., Banaschewski, T., Sonuga-Barke, E., Eisenberg, J., Kuntsi, J., Manor, I., McGuffin, P., Miranda, A., Oades, R. D., Plomin, R., Roeyers, H., Rothenberger, A., Sergeant, J., Steinhausen, H-C., Taylor, E., Thompson, M., Faraone, S. V. & Asherson, P., 10/2006, In: Molecular Psychiatry. 11, 10, p. 934-953 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy

    Brookes, K-J., Mill, J., Guindalini, C., Curran, S., Xu, X., Knight, J., Chen, C-K., Huang, Y-S., Sethna, V., Taylor, E., Chen, W., Breen, G. & Asherson, P., 01/2006, In: Archives of General Psychiatry. 63, 1, p. 74-81 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters

    Brookes, K. J., Knight, J., Xu, X. & Asherson, P., 5/11/2005, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 139B, 1, p. 33-37 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2015, In: Nature Genetics. 47, 3, p. 291-295 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children

    Butcher, L. M., Meaburn, E., Knight, J., Sham, P. C., Schalkwyk, L. C., Craig, I. W. & Plomin, R., 15/05/2005, In: Human Molecular Genetics. 14, 10, p. 1315-1325 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Software for generating liability distributions for pedigrees conditional on their observed disease states and covariates

    Campbell, D. D., Sham, P. C., Knight, J., Wickham, H. & Landau, S., 02/2010, In: Genetic Epidemiology. 34, 2, p. 159-170 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Genome-wide mapping of human loci for essential hypertension

    Caulfield, M., Munroe, P., Pembroke, J., Samani, N., Dominiczak, A., Brown, M., Benjamin, N., Webster, J., Ratcliffe, P., O'Shea, S., Papp, J., Taylor, E., Dobson, R., Knight, J., Newhouse, S., Hooper, J., Lee, W., Brain, N., Clayton, D., Lathrop, G. M. & 3 others, Farrall, M., Connell, J. & MRC British Genetics of Hypertension Study, 21/06/2003, In: The Lancet. 361, 9375, p. 2118-2123 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Genes for hypertension

    Caulfield, M., Knight, J., Gardener, G., O’Shea, S. & Monroe, P., 2002, An introduction to vascular biology: from basic science to clinical practice. Hunt, B. J. (ed.). 2nd ed ed. Cambridge: Cambridge University Press

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter

  30. Published

    DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage

    Chen, W., Zhou, K., Sham, P., Franke, B., Kuntsi, J., Campbell, D., Fleischman, K., Knight, J., Andreou, P., Arnold, R., Altink, M., Boer, F., Boholst, M. J., Buschgens, C., Butler, L., Christiansen, H., Fliers, E., Howe-Forbes, R., Gabriëls, I., Heise, A. & 30 others, Korn-Lubetzki, I., Marco, R., Medad, S., Minderaa, R., Müller, U. C., Mulligan, A., Psychogiou, L., Rommelse, N., Sethna, V., Uebel, H., McGuffin, P., Plomin, R., Banaschewski, T., Buitelaar, J., Ebstein, R., Eisenberg, J., Gill, M., Manor, I., Miranda, A., Mulas, F., Oades, R. D., Roeyers, H., Rothenberger, A., Sergeant, J., Sonuga-Barke, E., Steinhausen, H-C., Taylor, E., Thompson, M., Faraone, S. V. & Asherson, P., 5/12/2008, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 147B, 8, p. 1450-1460 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences

    Chenoweth, M. J., Ware, J. J., Zhu, A. Z. X., Cole, C. B., Cox, L. S., Nollen, N., Ahluwalia, J. S., Benowitz, N. L., Schnoll, R. A., Hawk, L. W., Cinciripini, P. M., George, T. P., Lerman, C., Knight, J., Tyndale, R. F. & PGRN-PNAT Research Group, 03/2018, In: Addiction. 113, 3, p. 509-523 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. E-pub ahead of print

    A genome-wide association study of nausea incidence in varenicline-treated cigarette smokers

    Chenoweth, M. J., Lerman, C., Knight, J. & Tyndale, R. F., 31/10/2021, In: Nicotine and Tobacco Research. 23, 10, p. 1805-1809 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans

    Chenoweth, M. J., Cox, L. S., Nollen, N. L., Ahluwalia, J. S., Benowitz, N. L., Lerman, C., Knight, J. & Tyndale, R. F., 1/10/2021, In: Scientific Reports. 11, 1, 12 p., 19572.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Haplotype and linkage disequilibrium analysis to characterise a region in the calcium channel gene CACNA1A associated with idiopathic generalised epilepsy

    Chioza, B., Osei-Lah, A., Nashef, L., Suarez-Merino, B., Wilkie, H., Sham, P., Knight, J., Asherson, P. & Makoff, A. J., 12/2002, In: European Journal of Human Genetics. 10, 12, p. 857-864 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    The Bipolar Association Case-Control Study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

    Cohen-Woods, S., Craig, I., Gaysina, D., Gray, J., Gunasinghe, C., Craddock, N., Elkin, A., Jones, L., Kennedy, J., King, N., Korszun, A., Knight, J., Owen, M., Parikh, S., Strauss, J., Sterne, A., Tozzi, F., Perry, J., Muglia, P., Vincent, J. & 2 others, McGuffin, P. & Farmer, A., 5/10/2010, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 153B, 7, p. 1298-1304 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder

    Cohen-Woods, S., Gaysina, D., Craddock, N., Farmer, A., Gray, J., Gunasinghe, C., Hoda, F., Jones, L., Knight, J., Korszun, A., Owen, M. J., Sterne, A., Craig, I. W. & McGuffin, P., 15/04/2009, In: Human Molecular Genetics. 18, 8, p. 1504-1509 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Program report: GENECOUNTING support programs

    Curtis, D., Knight, J. & Sham, P. C., 03/2006, In: Annals of Human Genetics. 70, Pt 2, p. 277-279 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigrees

    Curtis, D., Knight, J. & Sham, P. C., 09/2005, In: Psychiatric Genetics. 15, 3, p. 181-187 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Investigation into the ability of SNP chipsets and microsatellites to detect association with a disease locus

    Curtis, D., Vine, A. E. & Knight, J., 07/2008, In: Annals of Human Genetics. 72, 4, p. 547-556 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    Study of regions of extended homozygosity provides a powerful method to explore haplotype structure of human populations

    Curtis, D., Vine, A. E. & Knight, J., 03/2008, In: Annals of Human Genetics. 72, 2, p. 261-278 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    A simple method for assessing the strength of evidence for association at the level of the whole gene

    Curtis, D., Vine, A. E. & Knight, J., 17/11/2008, In: Advances and Applications in Bioinformatics and Chemistry : AABC. 1, p. 115-120 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studies

    Curtis, D., Vine, A. E. & Knight, J., 10/05/2007, In: Genetics. 8, 6 p., 20.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Dopamine genes and pathological gambling in discordant sib-pairs

    da Silva Lobo, D. S., Vallada, H. P., Knight, J., Martins, S. S., Tavares, H., Gentil, V. & Kennedy, J. L., 12/2007, In: Journal of Gambling Studies. 23, 4, p. 421-433 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    The effect of haplotype-block definitions on inference of haplotype-block structure and htSNPs selection

    Ding, K., Zhou, K., Zhang, J., Knight, J., Zhang, X. & Shen, Y., 01/2005, In: Molecular Biology and Evolution. 22, 1, p. 148-159 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Profiling Medical Journal Articles Using a Gene Ontology Semantic Tagger

    El Haj, M., Rayson, P. E., Piao, S. S. & Knight, J., 11/05/2018, LREC 2018, Eleventh International Conference on Language Resources and Evaluation. Calzolari, N., Choukri, K., Cieri, C., Declerck, T., Goggi, S., Hasida, K., Isahara, H., Maegaard, B., Mariani, J., Mazo, H., Moreno, A., Odijk, J., Piperidis, S. & Tokunaga, T. (eds.). European Language Resources Association (ELRA), p. 4593-4597 5 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNConference contribution/Paperpeer-review

  46. E-pub ahead of print

    Transferability Of Ancestry-Specific And Cross-Ancestry CYP2A6 Activity Genetic Risk Scores In African And European Populations

    El-Boraie, A., Chenoweth, M. J., Pouget, J. G., Benowitz, N. L., Fukunaga, K., Mushiroda, T., Kubo, M., Nollen, N. L., Cox, L. S., Lerman, C., Knight, J. & Tyndale, R. F., 31/10/2021, In: Clinical pharmacology and therapeutics. 110, 4, p. 975-985 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    A Comparison Between Genetics Papers Relating to Immune Disorders and Psychiatric Disorders

    El-Haj, M., Piao, S. S., Rayson, P. E. & Knight, J., 11/09/2017.

    Research output: Contribution to conference - Without ISBN/ISSN Posterpeer-review

  48. Published

    Infrastructure for Semantic Annotation in the Genomics Domain

    El-Haj, M., Rutherford, N., Coole, M., Ezeani, I., Prentice, S., Ide, N., Knight, J., Piao, S., Mariani, J., Rayson, P. & Suderman, K., 11/05/2020, LREC 2020, Twelfth International Conference on Language Resources and Evaluation: LREC'20. Paris: European Language Resources Association (ELRA), p. 6921-6929 9 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNConference contribution/Paperpeer-review

  49. Published

    Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

    Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., Karaman, I., Ng, F. L., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, J. N., Giri, A., Velez Edwards, D. R., Sun, Y. V., Cho, K., Gaziano, J. M. & 31 others, Wilson, P. W. F., Tsao, P. S., Kovesdy, C. P., Esko, T., Mägi, R., Milani, L., Almgren, P., Boutin, T., Debette, S., Ding, J., Giulianini, F., Holliday, E. G., Jackson, A. U., Li-Gao, R., Lin, W-Y., Luan, J., Mangino, M., Oldmeadow, C., Prins, B. P., Qian, Y., Sargurupremraj, M., Shah, N., Surendran, P., Thériault, S., Verweij, N., Willems, S. M., Zhao, J-H., Amouyel, P., Connell, J., Knight, J. & Million Veteran Program, 17/09/2018, In: Nature Genetics. 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Genetic epistasis regulates amyloid deposition in resilient aging

    Felsky, D., Xu, J., Chibnik, L., Schneider, J., Knight, J., Kennedy, J. L., Bennett, D. A., De Jager, P. L. & Voineskos, A. N., 10/2017, In: Alzheimer's and Dementia. 13, 10, p. 1107-1116 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene

    Flomen, R., Knight, J., Sham, P., Kerwin, R. & Makoff, A., 1/04/2004, In: Nucleic Acids Research. 32, 7, p. 2113-2122 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality

    Fogh, I., Rijsdijk, F., Andersen, P. M., Sham, P. C., Knight, J., Neale, B., McKenna-Yasek, D., Silani, V., Brown, R. H., Powell, J. F. & Al-Chalabi, A., 08/2007, In: Neurogenetics. 8, 3, p. 235-236 2 p.

    Research output: Contribution to journalLetterpeer-review

  53. Published

    Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2016, In: Nature Reviews Neuroscience. 19, 3, p. 420-431 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    Allele-skewed DNA modification in the brain: relevance to a schizophrenia GWAS

    Gagliano, S. A., Ptak, C., Mak, D. Y. F., Shamsi, M., Oh, G., Knight, J., Boutros, P. C. & Petronis, A., 5/05/2016, In: American Journal of Human Genetics. 98, 5, p. 956-962 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Smoking gun or circumstantial evidence? comparison of statistical learning methods using functional annotations for prioritizing risk variants

    Gagliano, S. A., Ravji, R., Barnes, M. R., Weale, M. E. & Knight, J., 24/08/2015, In: Scientific Reports. 5, 11 p., 13373.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    Assessing models for genetic prediction of complex traits: a comparison of visualization and quantitative methods

    Gagliano, S. A., Paterson, A. D., Weale, M. E. & Knight, J., 22/05/2015, In: BMC Genomics. 16, 11 p., 405.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization

    Gagliano, S. A., Barnes, M. R., Weale, M. E. & Knight, J., 20/05/2014, In: PLoS ONE. 9, 5, 14 p., e98122.

    Research output: Contribution to journalJournal articlepeer-review

  58. Published

    Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain

    Gagliano, S. A., Tiwari, A. K., Freeman, N., Lieberman, J. A., Meltzer, H. Y., Kennedy, J. L., Knight, J. & Müller, D. J., 07/2014, In: Human Psychopharmacology: Clinical and Experimental. 29, 4, p. 330-335 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  59. Published

    Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseases

    Gagliano, S. A., Pouget, J. G., Hardy, J., Knight, J., Barnes, M. R., Ryten, M. & Weale, M., 12/2016, In: Annals of Clinical and Translational Neurology. 3, 12, p. 924-933 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  60. Published

    TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease

    Garcia-Barcelo, M., Ganster, R. W., Lui, V. C. H., Leon, T. Y. Y., So, M-T., Lau, A. M. F., Fu, M., Sham, M-H., Knight, J., Zannini, M. S., Sham, P. C. & Tam, P. K. H., 15/01/2005, In: Human Molecular Genetics. 14, 2, p. 191-204 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  61. Published

    Examining the role of common and rare mitochondrial variants in schizophrenia

    Gonçalves, V. F., Giamberardino, S. N., Crowley, J. J., Vawter, M. P., Saxena, R., Bulik, C. M., Yilmaz, Z., Hultman, C. M., Sklar, P., Kennedy, J. L., Sullivan, P. F. & Knight, J., 25/01/2018, In: PLoS ONE. 13, 1, e0191153.

    Research output: Contribution to journalJournal articlepeer-review

  62. Published

    Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 6/11/2014, In: American Journal of Human Genetics. 95, 5, p. 535-552 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  63. Published

    Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 04/2018, In: Nature Genetics. 50, 4, p. 538-548 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  64. Published

    Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease

    Hamilton, G., Samedi, F., Knight, J., Archer, N., Foy, C., Walter, S., Turic, D., Jehu, L., Moore, P., Hollingworth, P., O'Donovan, M. C., Williams, J., Owen, M. J., Lovestone, S. & Powell, J. F., 19/06/2006, In: Neuroscience Letters. 401, 1-2, p. 77-80 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  65. Published

    Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease

    Hassan, A. E. M., Gormley, K., O'Sullivan, M., Knight, J., Sham, P. C., Vallance, P., Bamford, J. & Markus, H. S., 03/2004, In: Stroke; a journal of cerebral circulation. 35, 3, p. 654-659 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  66. Published

    Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 04/2016, In: JAMA Psychiatry. 73, 4, p. 369-377 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  67. Published

    Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 16/02/2016, In: Frontiers in Genetics. 7, 13 p., 15.

    Research output: Contribution to journalJournal articlepeer-review

  68. Published

    Fine-mapping inflammatory bowel disease loci to single-variant resolution

    Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C. A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K. K-H., Franke, A., Gori, A-S., Goyette, P., Halfvarson, J. & 27 others, Haritunians, T., Knight, J., Lawrance, I. C., Lees, C. W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S. L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R. J., Weersma, R. K., Duerr, R. H., Mathew, C. G., Rioux, J. D., McGovern, D. P. B., Cho, J. H., Georges, M., Daly, M. J., Barrett, J. C. & International Inflammatory Bowel Disease Genetics Consortium, 13/07/2017, In: Nature. 547, 7662, p. 173-178 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  69. Published

    No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 28/10/2016, In: PLoS Genetics. 12, 10, 20 p., e1006343.

    Research output: Contribution to journalJournal articlepeer-review

  70. Published

    A modelling framework for developing early warning systems of COPD emergency admissions

    Johnson, O., Knight, J. & Giorgi, E., 1/02/2021, In: Spatial and Spatio-temporal Epidemiology. 36, 9 p., 100392.

    Research output: Contribution to journalJournal articlepeer-review

  71. Published

    COVID-19 exposes the urgent need for coding of outpatient neurology episodes

    Kemp, M., Biggin, F., Dayanandan, R., Knight, J. & Emsley, H. C. A., 31/08/2020, In: BMJ Neurology Open. 2, 2, 2 p., e000080.

    Research output: Contribution to journalEditorialpeer-review

  72. Published

    IBD genetic risk profile in healthy first-degree relatives of Crohn's disease patients

    Kevans, D., Silverberg, M. S., Borowski, K., Griffiths, A., Xu, W., Onay, V., Paterson, A. D., Knight, J., Croitoru, K. & GEM Project, 02/2016, In: Journal of Crohn's and Colitis. 10, 2, p. 209-215 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  73. Published

    Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis

    Knight, J., Spain, S. L., Capon, F., Hayday, A., Nestle, F. O., Clop, A., Barker, J. N. W. N., Weale, M. E., Trembath, R. C. & Wellcome Trust Case Control Consortium, 1/12/2012, In: Human Molecular Genetics. 21, 23, p. 5185-5192 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  74. Published

    Human chromosome 17 in essential hypertension

    Knight, J., Munroe, P. B., Pembroke, J. C. & Caulfield, M. J., 03/2003, In: Annals of Human Genetics. 67, 2, p. 193-206 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  75. Published

    Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans

    Knight, J., Gardner, G. T., Clark, A. J. & Caulfield, M. J., 06/2000, In: Journal of Human Hypertension. 14, 6, p. 385-387 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  76. Published

    CLUMPHAP: a simple tool for performing haplotype-based association analysis

    Knight, J., Curtis, D. & Sham, P. C., 09/2008, In: Genetic Epidemiology. 32, 6, p. 539-545 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  77. Published

    Design and analysis of association studies using pooled DNA from large twin samples

    Knight, J. & Sham, P., 09/2006, In: Behavior Genetics. 36, 5, p. 665-677 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  78. Published

    Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait

    Knight, J., North, B. V., Sham, P. C. & Curtis, D., 31/12/2003, In: Genetics. 4 , Suppl. 1, 4 p., S74.

    Research output: Contribution to journalJournal articlepeer-review

  79. Published

    Using functional annotation for the empirical determination of Bayes Factors for genome-wide association study analysis

    Knight, J., Barnes, M. R., Breen, G. & Weale, M. E., 27/04/2011, In: PLoS ONE. 6, 4, 8 p., e14808.

    Research output: Contribution to journalJournal articlepeer-review

  80. Published

    An investigation of candidate regions for association with bipolar disorder

    Knight, J., Rochberg, N. S., Saccone, S. F., Nurnberger, J. I., Rice, J. P. & NIMH Genetics Initiative Bipolar Disorder Consortium, 5/10/2010, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 153B, 7, p. 1292-1297 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  81. Published

    A comparison of association statistics between pooled and individual genotypes

    Knight, J., Saccone, S. F., Zhang, Z., Ballinger, D. G. & Rice, J. P., 03/2009, In: Human Heredity. 67, 4, p. 219-225 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  82. Published

    A survey of current software for genetic power calculations

    Knight, J., 2/03/2004, In: BMC Genomics. 1, 3, p. 225-227 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  83. Published

    Regional multi-locus association models

    Knight, J., Sham, P., Shaun, P. & Neale, B., 2007, Statistical genetics: gene mapping through linkage and association. Neale, B., Ferreira, M., Medland, S. & Posthuma, D. (eds.). London: Taylor and Francis

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter

  84. Published

    Connected Health Cities – Lancaster – the north west coast and beyond

    Knight, J. & King, N. S., 23/04/2018, In: Morecambe Bay Medical Journal. 7, 12, p. 310-310 1 p.

    Research output: Contribution to journalJournal article

  85. Published

    Complex host genetics influence the microbiome in inflammatory bowel disease

    Knights, D., Silverberg, M. S., Weersma, R. K., Gevers, D., Dijkstra, G., Huang, H., Tyler, A. D., van Sommeren, S., Imhann, F., Stempak, J. M., Huang, H., Vangay, P., Al-Ghalith, G. A., Russell, C., Sauk, J., Knight, J., Daly, M. J., Huttenhower, C. & Xavier, R. J., 2/12/2014, In: Genome Biology. 6, 12, 11 p., 107.

    Research output: Contribution to journalJournal articlepeer-review

  86. Published

    Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 26/06/2016, In: Schizophrenia Bulletin. 43, 3, p. 654-664 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  87. Published

    Introduction to genetic association studies

    Lewis, C. M. & Knight, J., 03/2012, In: Cold Spring Harbor Protocols. 2012, 3, p. 297-306 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  88. Published

    A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 06/2018, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 177, 4, p. 454-467 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  89. Published

    Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models

    Lobo, D. S. S., Aleksandrova, L., Knight, J., Casey, D. M., el-Guebaly, N., Nobrega, J. N. & Kennedy, J. L., 08/2015, In: Molecular Psychiatry. 20, 8, p. 1002-1010 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  90. Published

    Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

    Schizophrenia Working Group of Psychiatric Genomics Consortium, 12/2015, In: Nature Genetics. 47, 12, p. 1385-1392 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  91. Published

    Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study

    Masellis, M., Collinson, S., Freeman, N., Tampakeras, M., Levy, J., Tchelet, A., Eyal, E., Berkovich, E., Eliaz, R. E., Abler, V., Grossman, I., Fitzer-Attas, C., Tiwari, A., Hayden, M. R., Kennedy, J. L., Lang, A. E., Knight, J. & ADAGIO investigators, 07/2016, In: Brain. 139, 7, p. 2050-2062 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  92. Published

    Unraveling DNA sequence to identify cerebral indicators of dementia risk

    Masellis, M. & Knight, J., 16/01/2018, In: Neurology. 90, 3, p. 109 1 p.

    Research output: Contribution to journalComment/debate

  93. Published

    Whole genome linkage scan of recurrent depressive disorder from the depression network study

    McGuffin, P., Knight, J., Breen, G., Brewster, S., Boyd, P. R., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M. J., Perry, J., Preisig, M., Reich, T., Rice, J., Rietschel, M., Jones, L., Sham, P. & Farmer, A. E., 15/11/2005, In: Human Molecular Genetics. 14, 22, p. 3337-3345 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  94. Published

    Homing in on depression genes

    McGuffin, P., Cohen, S. & Knight, J., 02/2007, In: American Journal of Psychiatry. 164, 2, p. 195-197 3 p.

    Research output: Contribution to journalEditorialpeer-review

  95. Published

    Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

    Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 21/03/2017, In: Nature Communications. 8, 12 p., 14774.

    Research output: Contribution to journalJournal articlepeer-review

  96. Published

    Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B

    Mill, J., Xu, X., Ronald, A., Curran, S., Price, T., Knight, J., Craig, I., Sham, P., Plomin, R. & Asherson, P., 5/02/2005, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 133B, 1, p. 68-73 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  97. Published

    Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD

    Mill, J., Richards, S., Knight, J., Curran, S., Taylor, E. & Asherson, P., 08/2004, In: Molecular Psychiatry. 9, 8, p. 801-810 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  98. Published

    1990-2000: progress in determining high blood pressure genes

    Munroe, P. B., Knight, J. & Caulfield, M. J., 05/2000, In: Annals of the Academy of Medicine, Singapore. 29, 3, p. 357-363 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  99. Published

    CEREBRAL PERFUSION AS AN IMAGING BIOMARKER OF PRESYMPTOMATIC GENETIC FRONTOTEMPORAL DEMENTIA: PRELIMINARY RESULTS FROM THE GENETIC FRONTOTEMPORAL DEMENTIA INITIATIVE (GENFI)

    Mutsaerts, H. J. M. M. & Knight, J., 07/2016, In: Alzheimer's and Dementia. 12, 7 Suppl., p. P409-P411 3 p.

    Research output: Contribution to journalMeeting abstract

  100. Published

    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

    Navarini, A. A., Simpson, M. A., Weale, M., Knight, J., Carlavan, I., Reiniche, P., Burden, D. A., Layton, A., Bataille, V., Allen, M., Pleass, R., Pink, A., Creamer, D., English, J., Munn, S., Walton, S., Willis, C., Déret, S., Voegel, J. J., Spector, T. & 4 others, Smith, C. H., Trembath, R. C., Barker, J. N. W. N. & Acne Genetic Study Group, 13/06/2014, In: Nature Communications. 5, 6 p., 4020.

    Research output: Contribution to journalJournal articlepeer-review

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