Accuracy and applications of sequencing and genotyping approaches for CYP2A6 and homologous genes

Langlois, A. W. R., El-Boraie, A., Fukunaga, K., Mushiroda, T., Kubo, M., Lerman, C., Knight, J., Scherer, S. E., Chenoweth, M. J. & Tyndale, R. F., 30/06/2022, In: Pharmacogenetics and genomics. 32, 4, p. 159-172 14 p.

Research output: Contribution to journal › Journal article › peer-review

Are child health information services a viable source of accurate vaccination data for clinicians working in paediatric emergency departments in England?

Isba, R., Davies, N. & Knight, J., 31/12/2021, In: BMJ health & care informatics. 28, 1, 3 p., e100486.

Research output: Contribution to journal › Journal article › peer-review

A Domain Based Approach to Semantic Lexicon Expansion

Prentice, S., Rayson, P., Knight, J., El-Haj, M. & Elstein, S., 4/12/2021, (E-pub ahead of print) In: International Journal of Lexicography. 16 p.

Research output: Contribution to journal › Journal article › peer-review

Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis

Chenoweth, M. J., Peng, A. R., Zhu, A. Z. X., Cox, L. S., Nollen, N. L., Ahluwalia, J. S., Benowitz, N. L., Knight, J., Swardfager, W. & Tyndale, R. F., 30/06/2022, In: Addiction. 117, 6, p. 1715-1724 10 p.

Research output: Contribution to journal › Journal article › peer-review

A genome-wide association study of nausea incidence in varenicline-treated cigarette smokers

Chenoweth, M. J., Lerman, C., Knight, J. & Tyndale, R. F., 31/10/2021, In: Nicotine and Tobacco Research. 23, 10, p. 1805-1809 5 p.

Research output: Contribution to journal › Journal article › peer-review

Transferability Of Ancestry-Specific And Cross-Ancestry CYP2A6 Activity Genetic Risk Scores In African And European Populations

El-Boraie, A., Chenoweth, M. J., Pouget, J. G., Benowitz, N. L., Fukunaga, K., Mushiroda, T., Kubo, M., Nollen, N. L., Cox, L. S., Lerman, C., Knight, J. & Tyndale, R. F., 31/10/2021, In: Clinical pharmacology and therapeutics. 110, 4, p. 975-985 11 p.

Research output: Contribution to journal › Journal article › peer-review

Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans

Chenoweth, M. J., Cox, L. S., Nollen, N. L., Ahluwalia, J. S., Benowitz, N. L., Lerman, C., Knight, J. & Tyndale, R. F., 1/10/2021, In: Scientific Reports. 11, 1, 12 p., 19572.

Research output: Contribution to journal › Journal article › peer-review

Problematising Characteristicness: A Biomedical Association Case Study

Prentice, S., Knight, J., Rayson, P., El-Haj, M. & Rutherford, N., 31/08/2021, In: International Journal of Corpus Linguistics. 26, 3, p. 305-335 31 p.

Research output: Contribution to journal › Journal article › peer-review

Variation in waiting times by diagnostic category: an observational study of 1,951 referrals to a neurology outpatient clinic

Biggin, F., Howcroft, T., Davies, Q., Knight, J. & Emsley, H., 31/05/2021, In: BMJ Neurology Open. 3, 1, 8 p., 000133.

Research output: Contribution to journal › Journal article › peer-review

A modelling framework for developing early warning systems of COPD emergency admissions

Johnson, O., Knight, J. & Giorgi, E., 1/02/2021, In: Spatial and Spatio-temporal Epidemiology. 36, 9 p., 100392.

Research output: Contribution to journal › Journal article › peer-review

Late-onset epilepsy predicts stroke: Systematic review and meta-analysis

Wall, J., Knight, J. & Emsley, H. C. A., 1/02/2021, In: Epilepsy and Behavior. 115, 6 p., 107634.

Research output: Contribution to journal › Review article › peer-review

Routinely collected patient data in neurology research: a systematic mapping review

Biggin, F., Emsley, H. & Knight, J., 27/11/2020, In: BMC Neurology. 20, 9 p., 431.

Research output: Contribution to journal › Journal article › peer-review

COVID-19 exposes the urgent need for coding of outpatient neurology episodes

Kemp, M., Biggin, F., Dayanandan, R., Knight, J. & Emsley, H. C. A., 31/08/2020, In: BMJ Neurology Open. 2, 2, 2 p., e000080.

Research output: Contribution to journal › Editorial › peer-review

Complement genes contribute sex-biased vulnerability in diverse disorders

Schizophrenia Working Group of the Psychiatric Genomics Consortium 2, 11/05/2020, (E-pub ahead of print) In: Nature. 28 p.

Research output: Contribution to journal › Journal article › peer-review

The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia

GROUP Investigators & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 1/03/2020, In: Schizophrenia Bulletin. 46, 2, p. 336-344 9 p.

Research output: Contribution to journal › Journal article › peer-review

Comparative genetic architectures of schizophrenia in East Asian and European populations

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 31/12/2019, In: Nature Genetics. 51, 12, p. 1670-1678 9 p.

Research output: Contribution to journal › Journal article › peer-review

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

ADHD Working Group of the Psychiatric Genomics Consortium, 18/12/2019, In: Nature Communications. 10, 1, 12 p., 5765.

Research output: Contribution to journal › Journal article › peer-review

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu, 12/12/2019, In: Cell. 179, 7, p. 1469-1482.e11 14 p.

Research output: Contribution to journal › Journal article › peer-review

Can we accurately classify schizophrenia patients from healthy controls using magnetic resonance imaging and machine learning? A multi-method and multi-dataset study

Winterburn, J. L., Voineskos, A. N., Devenyi, G. A., Plitman, E., de la Fuente-Sandoval, C., Bhagwat, N., Graff-Guerrero, A., Knight, J. & Chakravarty, M. M., 1/12/2019, In: Schizophrenia Research. 214, p. 3-10 8 p.

Research output: Contribution to journal › Journal article › peer-review

APOE-ɛ4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia

Saeed Mirza, S., Saeed, U., Knight, J., Ramirez, J., Stuss, D., Keith, J., Nestor, S. M., Yu, D., Swardfager, W., Rogaeva, E., George-Hyslop, P. S., Black, S. E. & Masellis, M., 5/11/2019, In: Neurology. 93, 19, p. e1807-e1819 13 p.

Research output: Contribution to journal › Journal article › peer-review

Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk

Pouget, J. G., Han, B., Wu, Y., Mignot, E., Ollila, H. M., Barker, J., Spain, S., Dand, N., Trembath, R., Martin, J., Mayes, M. D., Bossini-Castillo, L., López-Isac, E., Jin, Y., Santorico, S. A., Spritz, R. A., Hakonarson, H., Polychronakos, C., Raychaudhuri, S., Knight, J. & 1 others, Schizophrenia Working Group of the Psychiatric Genomics Consortium, 15/10/2019, In: Human Molecular Genetics. 28, 20, p. 3498-3513 16 p.

Research output: Contribution to journal › Journal article › peer-review

A polygenic resilience score moderates the genetic risk for schizophrenia

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 6/09/2019, In: Molecular Psychiatry. 2019, 16 p.

Research output: Contribution to journal › Journal article › peer-review

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

M.R.C.Psych & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 1/08/2019, In: American Journal of Psychiatry. 176, 8, p. 651-660 10 p.

Research output: Contribution to journal › Journal article › peer-review

The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia

Schizophrenia Working Group of the Psychiatric Genomics Consortium 2, 1/08/2019, In: Neuropsychopharmacology. 44, 9, p. 1562-1569 8 p.

Research output: Contribution to journal › Journal article › peer-review

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

CommonMind Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & iPSYCH-GEMS Schizophrenia Working Group, 1/04/2019, In: Nature Genetics. 51, 4, p. 659-674 16 p.

Research output: Contribution to journal › Journal article › peer-review

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Wellcome Trust Case Control Consortium 2 & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 1/04/2019, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 180, 3, p. 223-231 9 p.

Research output: Contribution to journal › Journal article › peer-review

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium, Rhodes, C. J., Batai, K., Bleda, M., Haimel, M., Southgate, L., Germain, M., Pauciulo, M. W., Hadinnapola, C., Aman, J., Girerd, B., Arora, A., Knight, J., Hanscombe, K. B., Karnes, J. H., Kaakinen, M., Gall, H., Ulrich, A. & 33 others, Harbaum, L., Cebola, I., Ferrer, J., Lutz, K., Swietlik, E. M., Ahmad, F., Amouyel, P., Archer, S. L., Argula, R., Austin, E. D., Badesch, D., Bakshi, S., Barnett, C., Benza, R., Bhatt, N., Bogaard, H. J., Burger, C. D., Chakinala, M., Church, C., Coghlan, J. G., Condliffe, R., Corris, P. A., Danesino, C., Debette, S., Elliott, C. G., Elwing, J., Eyries, M., Fortin, T., Franke, A., Frantz, R. P., Frost, A., Garcia, J. G. N. & Ghio, S., 1/03/2019, In: Lancet Respiratory Medicine. 7, 3, p. 227-238 12 p.

Research output: Contribution to journal › Journal article › peer-review

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., Karaman, I., Ng, F. L., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, J. N., Giri, A., Velez Edwards, D. R., Sun, Y. V., Cho, K., Gaziano, J. M. & 31 others, Wilson, P. W. F., Tsao, P. S., Kovesdy, C. P., Esko, T., Mägi, R., Milani, L., Almgren, P., Boutin, T., Debette, S., Ding, J., Giulianini, F., Holliday, E. G., Jackson, A. U., Li-Gao, R., Lin, W-Y., Luan, J., Mangino, M., Oldmeadow, C., Prins, B. P., Qian, Y., Sargurupremraj, M., Shah, N., Surendran, P., Thériault, S., Verweij, N., Willems, S. M., Zhao, J-H., Amouyel, P., Connell, J., Knight, J. & Million Veteran Program, 17/09/2018, In: Nature Genetics. 20 p.

Research output: Contribution to journal › Journal article › peer-review

APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies

Saeed, U., Mirza, S. S., MacIntosh, B. J., Herrmann, N., Keith, J., Ramirez, J., Nestor, S. M., Yu, Q., Knight, J., Swardfager, W., Potkin, S. G., Rogaeva, E., George-Hyslop, P. S., Black, S. E. & Masellis, M., 09/2018, In: Alzheimer's and Dementia. 14, 9, p. 1137-1147 11 p.

Research output: Contribution to journal › Journal article › peer-review

Heritability estimates of cortical anatomy: The influence and reliability of different estimation strategies

Patel, S., Patel, R., Park, M. T. M., Masellis, M., Knight, J. & Chakravarty, M. M., 09/2018, In: NeuroImage. 178, p. 78-91 14 p.

Research output: Contribution to journal › Journal article › peer-review

Age at first birth in women is genetically associated with increased risk of schizophrenia

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 5/07/2018, In: Scientific Reports. 8, 1, 14 p., 10168.

Research output: Contribution to journal › Journal article › peer-review

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium, 14/06/2018, In: Cell. 173, 7, p. 1705-1715.e16 11 p.

Research output: Contribution to journal › Journal article › peer-review

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 7/06/2018, In: American Journal of Human Genetics. 102, 6, p. 1185-1194 10 p.

Research output: Contribution to journal › Journal article › peer-review

A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 06/2018, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 177, 4, p. 454-467 14 p.

Research output: Contribution to journal › Journal article › peer-review

Connected Health Cities – Lancaster – the north west coast and beyond

Knight, J. & King, N. S., 23/04/2018, In: Morecambe Bay Medical Journal. 7, 12, p. 310-310 1 p.

Research output: Contribution to journal › Journal article

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 04/2018, In: Nature Genetics. 50, 4, p. 538-548 11 p.

Research output: Contribution to journal › Journal article › peer-review

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences

Chenoweth, M. J., Ware, J. J., Zhu, A. Z. X., Cole, C. B., Cox, L. S., Nollen, N., Ahluwalia, J. S., Benowitz, N. L., Schnoll, R. A., Hawk, L. W., Cinciripini, P. M., George, T. P., Lerman, C., Knight, J., Tyndale, R. F. & PGRN-PNAT Research Group, 03/2018, In: Addiction. 113, 3, p. 509-523 15 p.

Research output: Contribution to journal › Journal article › peer-review

Examining the role of common and rare mitochondrial variants in schizophrenia

Gonçalves, V. F., Giamberardino, S. N., Crowley, J. J., Vawter, M. P., Saxena, R., Bulik, C. M., Yilmaz, Z., Hultman, C. M., Sklar, P., Kennedy, J. L., Sullivan, P. F. & Knight, J., 25/01/2018, In: PLoS ONE. 13, 1, e0191153.

Research output: Contribution to journal › Journal article › peer-review

Unraveling DNA sequence to identify cerebral indicators of dementia risk

Masellis, M. & Knight, J., 16/01/2018, In: Neurology. 90, 3, p. 109 1 p.

Research output: Contribution to journal › Comment/debate

Genetic epistasis regulates amyloid deposition in resilient aging

Felsky, D., Xu, J., Chibnik, L., Schneider, J., Knight, J., Kennedy, J. L., Bennett, D. A., De Jager, P. L. & Voineskos, A. N., 10/2017, In: Alzheimer's and Dementia. 13, 10, p. 1107-1116 10 p.

Research output: Contribution to journal › Journal article › peer-review

Heritability of hippocampal subfield volumes using a twin and non-twin siblings design

Patel, S., Park, M. T. M., Devenyi, G. A., Patel, R., Masellis, M., Knight, J. & Chakravarty, M. M., 09/2017, In: Human Brain Mapping. 38, 9, p. 4337-4352 16 p.

Research output: Contribution to journal › Journal article › peer-review

Fine-mapping inflammatory bowel disease loci to single-variant resolution

Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C. A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K. K-H., Franke, A., Gori, A-S., Goyette, P., Halfvarson, J. & 27 others, Haritunians, T., Knight, J., Lawrance, I. C., Lees, C. W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S. L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R. J., Weersma, R. K., Duerr, R. H., Mathew, C. G., Rioux, J. D., McGovern, D. P. B., Cho, J. H., Georges, M., Daly, M. J., Barrett, J. C. & International Inflammatory Bowel Disease Genetics Consortium, 13/07/2017, In: Nature. 547, 7662, p. 173-178 6 p.

Research output: Contribution to journal › Journal article › peer-review

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Schizophrenia Working Group of the Psychiatric Genomics Consortium & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, 20/06/2017, In: Translational Psychiatry. 7, 6, 9 p., e1155.

Research output: Contribution to journal › Journal article › peer-review

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 21/03/2017, In: Nature Communications. 8, 12 p., 14774.

Research output: Contribution to journal › Journal article › peer-review

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., Ntalla, I., Surendran, P., Liu, C., Cook, J. P., Kraja, A. T., Drenos, F., Loh, M., Verweij, N., Marten, J., Karaman, I., Lepe, M. P. S., O'Reilly, P. F., Knight, J., Snieder, H. & 31 others, Kato, N., He, J., Tai, E. S., Said, M. A., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R. T., Padmanabhan, S., Mägi, R., Stanton, A., Connell, J., Bakker, S. J. L., Metspalu, A., Shields, D. C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J. C., Chasman, D. I., Chakravarti, A., Newton-Cheh, C., Lindgren, C. M., Levy, D. & International Consortium of Blood Pressure (ICBP) 1000G Analyses, 20/02/2017, In: Nature Genetics. 49, p. 403-415 13 p.

Research output: Contribution to journal › Journal article › peer-review

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium, 01/2017, In: Nature Genetics. 49, p. 27-35 9 p.

Research output: Contribution to journal › Journal article › peer-review

Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseases

Gagliano, S. A., Pouget, J. G., Hardy, J., Knight, J., Barnes, M. R., Ryten, M. & Weale, M., 12/2016, In: Annals of Clinical and Translational Neurology. 3, 12, p. 924-933 10 p.

Research output: Contribution to journal › Journal article › peer-review

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 28/10/2016, In: PLoS Genetics. 12, 10, 20 p., e1006343.

Research output: Contribution to journal › Journal article › peer-review

Genome-wide association studies suggest limited immune gene enrichment in schizophrenia compared to 5 autoimmune diseases

Pouget, J. G., Gonçalves, V. F., Spain, S. L., Finucane, H. K., Raychaudhuri, S., Kennedy, J. L., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 09/2016, In: Schizophrenia Bulletin. 42, 5, p. 1176-1184 9 p.

Research output: Contribution to journal › Journal article › peer-review

Genetic Markers of Human Evolution Are Enriched in Schizophrenia

Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium, 15/08/2016, In: Biological Psychiatry. 80, 4, p. 284-92 9 p.

Research output: Contribution to journal › Journal article › peer-review

CEREBRAL PERFUSION AS AN IMAGING BIOMARKER OF PRESYMPTOMATIC GENETIC FRONTOTEMPORAL DEMENTIA: PRELIMINARY RESULTS FROM THE GENETIC FRONTOTEMPORAL DEMENTIA INITIATIVE (GENFI)

Mutsaerts, H. J. M. M. & Knight, J., 07/2016, In: Alzheimer's and Dementia. 12, 7 Suppl., p. P409-P411 3 p.

Research output: Contribution to journal › Meeting abstract

Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study

Masellis, M., Collinson, S., Freeman, N., Tampakeras, M., Levy, J., Tchelet, A., Eyal, E., Berkovich, E., Eliaz, R. E., Abler, V., Grossman, I., Fitzer-Attas, C., Tiwari, A., Hayden, M. R., Kennedy, J. L., Lang, A. E., Knight, J. & ADAGIO investigators, 07/2016, In: Brain. 139, 7, p. 2050-2062 13 p.

Research output: Contribution to journal › Journal article › peer-review

Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 26/06/2016, In: Schizophrenia Bulletin. 43, 3, p. 654-664 11 p.

Research output: Contribution to journal › Journal article › peer-review

Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium Mendelian randomization study

Prins, B. P., Abbasi, A., Wong, A., Vaez, A., Nolte, I., Franceschini, N., Stuart, P. E., Guterriez Achury, J., Mistry, V., Bradfield, J. P., Valdes, A. M., Bras, J., Shatunov, A., Lu, C., Han, B., Raychaudhuri, S., Bevan, S., Mayes, M. D., Tsoi, L. C., Evangelou, E. & 28 others, Nair, R. P., Grant, S. F. A., Polychronakos, C., Radstake, T. R. D., van Heel, D. A., Dunstan, M. L., Wood, N. W., Al-Chalabi, A., Dehghan, A., Hakonarson, H., Markus, H. S., Elder, J. T., Knight, J., Arking, D. E., Spector, T. D., Koeleman, B. P. C., van Duijn, C. M., Martin, J., Morris, A. P., Weersma, R. K., Wijmenga, C., Munroe, P. B., Perry, J. R. B., Pouget, J. G., Jamshidi, Y., Snieder, H., Alizadeh, B. Z. & PAGE Consortium, 21/06/2016, In: PLoS Medicine. 13, 6, 29 p., e1001976.

Research output: Contribution to journal › Journal article › peer-review

Allele-skewed DNA modification in the brain: relevance to a schizophrenia GWAS

Gagliano, S. A., Ptak, C., Mak, D. Y. F., Shamsi, M., Oh, G., Knight, J., Boutros, P. C. & Petronis, A., 5/05/2016, In: American Journal of Human Genetics. 98, 5, p. 956-962 7 p.

Research output: Contribution to journal › Journal article › peer-review

Gene prioritization for imaging genetics studies using gene ontology and a stratified false discovery rate approach

Patel, S., Park, M. T. M., Chakravarty, M. M., Knight, J. & Alzheimer's Disease Neuroimaging Initiative, 7/04/2016, In: Frontiers in Neuroinformatics. 10, 13 p., 14.

Research output: Contribution to journal › Journal article › peer-review

Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 04/2016, In: JAMA Psychiatry. 73, 4, p. 369-377 9 p.

Research output: Contribution to journal › Journal article › peer-review

Genetic association analysis of N-methyl-d-aspartate receptor subunit gene GRIN2B and clinical response to clozapine

Taylor, D. L., Tiwari, A. K., Lieberman, J. A., Potkin, S. G., Meltzer, H. Y., Knight, J., Remington, G., Müller, D. J. & Kennedy, J. L., 03/2016, In: Human Psychopharmacology: Clinical and Experimental. 31, 2, p. 121-134 14 p.

Research output: Contribution to journal › Journal article › peer-review

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2016, In: Nature Reviews Neuroscience. 19, 3, p. 420-431 12 p.

Research output: Contribution to journal › Journal article › peer-review

Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2016, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 171B, 2, p. 276-89 14 p.

Research output: Contribution to journal › Journal article › peer-review

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 16/02/2016, In: Frontiers in Genetics. 7, 13 p., 15.

Research output: Contribution to journal › Journal article › peer-review

Schizophrenia risk from complex variation of complement component 4

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 11/02/2016, In: Nature. 530, 7589, p. 177-183 7 p.

Research output: Contribution to journal › Journal article › peer-review

IBD genetic risk profile in healthy first-degree relatives of Crohn's disease patients

Kevans, D., Silverberg, M. S., Borowski, K., Griffiths, A., Xu, W., Onay, V., Paterson, A. D., Knight, J., Croitoru, K. & GEM Project, 02/2016, In: Journal of Crohn's and Colitis. 10, 2, p. 209-215 7 p.

Research output: Contribution to journal › Journal article › peer-review

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS

Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium, 01/2016, In: PLoS Genetics. 12, 1, 22 p., e1005803.

Research output: Contribution to journal › Journal article › peer-review

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

Schizophrenia Working Group of Psychiatric Genomics Consortium, 12/2015, In: Nature Genetics. 47, 12, p. 1385-1392 8 p.

Research output: Contribution to journal › Journal article › peer-review

Modeling linkage disequilibrium increases accuracy of polygenic risk scores

Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study, 1/10/2015, In: American Journal of Human Genetics. 97, 4, p. 576-592 17 p.

Research output: Contribution to journal › Journal article › peer-review

Predictors of outcome in ulcerative colitis

Waterman, M., Knight, J., Dinani, A., Xu, W., Stempak, J. M., Croitoru, K., Nguyen, G. C., Cohen, Z., McLeod, R. S., Greenberg, G. R., Steinhart, A. H. & Silverberg, M. S., 09/2015, In: Inflammatory Bowel Diseases. 21, 9, p. 2097-2105 9 p.

Research output: Contribution to journal › Journal article › peer-review

Smoking gun or circumstantial evidence? comparison of statistical learning methods using functional annotations for prioritizing risk variants

Gagliano, S. A., Ravji, R., Barnes, M. R., Weale, M. E. & Knight, J., 24/08/2015, In: Scientific Reports. 5, 11 p., 13373.

Research output: Contribution to journal › Journal article › peer-review

Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models

Lobo, D. S. S., Aleksandrova, L., Knight, J., Casey, D. M., el-Guebaly, N., Nobrega, J. N. & Kennedy, J. L., 08/2015, In: Molecular Psychiatry. 20, 8, p. 1002-1010 9 p.

Research output: Contribution to journal › Journal article › peer-review

A genome-wide association study of suicide severity scores in bipolar disorder

Zai, C. C., Gonçalves, V. F., Tiwari, A. K., Gagliano, S. A., Hosang, G., de Luca, V., Shaikh, S. A., King, N., Chen, Q., Xu, W., Strauss, J., Breen, G., Lewis, C. M., Farmer, A. E., McGuffin, P., Knight, J., Vincent, J. B. & Kennedy, J. L., 06/2015, In: Journal of Psychiatric Research. 65, p. 23-29 7 p.

Research output: Contribution to journal › Journal article › peer-review

Assessing models for genetic prediction of complex traits: a comparison of visualization and quantitative methods

Gagliano, S. A., Paterson, A. D., Weale, M. E. & Knight, J., 22/05/2015, In: BMC Genomics. 16, 11 p., 405.

Research output: Contribution to journal › Journal article › peer-review

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

Tsoi, L. C., Spain, S. L., Ellinghaus, E., Stuart, P. E., Capon, F., Knight, J., Tejasvi, T., Kang, H. M., Allen, M. H., Lambert, S., Stoll, S. W., Weidinger, S., Gudjonsson, J. E., Koks, S., Kingo, K., Esko, T., Das, S., Metspalu, A., Weichenthal, M., Enerback, C. & 13 others, Krueger, G. G., Voorhees, J. J., Chandran, V., Rosen, C. F., Rahman, P., Gladman, D. D., Reis, A., Nair, R. P., Franke, A., Barker, J. N. W. N., Abecasis, G. R., Trembath, R. C. & Elder, J. T., 5/05/2015, In: Nature Communications. 6, 8 p., 7001.

Research output: Contribution to journal › Journal article › peer-review

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2015, In: Nature Genetics. 47, 3, p. 291-295 5 p.

Research output: Contribution to journal › Journal article › peer-review

Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes

Prescott, N. J., Lehne, B., Stone, K., Lee, J. C., Taylor, K., Knight, J., Papouli, E., Mirza, M. M., Simpson, M. A., Spain, S. L., Lu, G., Fraternali, F., Bumpstead, S. J., Gray, E., Amar, A., Bye, H., Green, P., Chung-Faye, G., Hayee, BH., Pollok, R. & 10 others, Satsangi, J., Parkes, M., Barrett, J. C., Mansfield, J. C., Sanderson, J., Lewis, C. M., Weale, M. E., Schlitt, T., Mathew, C. G. & UK IBD Genetics Consortium, 11/02/2015, In: PLoS Genetics. 11, 2, e1004955.

Research output: Contribution to journal › Journal article › peer-review

CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers: findings from two independent populations

Wassenaar, C. A., Ye, Y., Cai, Q., Aldrich, M. C., Knight, J., Spitz, M. R., Wu, X., Blot, W. J. & Tyndale, R. F., 01/2015, In: Carcinogenesis. 36, 1, p. 99-103 5 p.

Research output: Contribution to journal › Journal article › peer-review

Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes

Pouget, J. G., Gonçalves, V. F., Nurmi, E. L., Laughlin, C. P., Mallya, K. S., McCracken, J. T., Aman, M. G., McDougle, C. J., Scahill, L., Misener, V. L., Tiwari, A. K., Zai, C. C., Brandl, E. J., Felsky, D., Leung, A. Q., Lieberman, J. A., Meltzer, H. Y., Potkin, S. G., Niedling, C., Steimer, W. & 4 others, Leucht, S., Knight, J., Müller, D. J. & Kennedy, J. L., 01/2015, In: Pharmacogenomics. 16, 1, p. 5-22 18 p.

Research output: Contribution to journal › Journal article › peer-review

Complex host genetics influence the microbiome in inflammatory bowel disease

Knights, D., Silverberg, M. S., Weersma, R. K., Gevers, D., Dijkstra, G., Huang, H., Tyler, A. D., van Sommeren, S., Imhann, F., Stempak, J. M., Huang, H., Vangay, P., Al-Ghalith, G. A., Russell, C., Sauk, J., Knight, J., Daly, M. J., Huttenhower, C. & Xavier, R. J., 2/12/2014, In: Genome Biology. 6, 12, 11 p., 107.

Research output: Contribution to journal › Journal article › peer-review

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 6/11/2014, In: American Journal of Human Genetics. 95, 5, p. 535-552 18 p.

Research output: Contribution to journal › Journal article › peer-review

The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa

Yilmaz, Z., Kaplan, A. S., Tiwari, A. K., Levitan, R. D., Piran, S., Bergen, A. W., Kaye, W. H., Hakonarson, H., Wang, K., Berrettini, W. H., Brandt, H. A., Bulik, C. M., Crawford, S., Crow, S., Fichter, M. M., Halmi, K. A., Johnson, C. L., Keel, P. K., Klump, K. L., Magistretti, P. & 7 others, Mitchell, J., Strober, M., Thornton, L. M., Treasure, J., Woodside, D. B., Knight, J. & Kennedy, J. L., 08/2014, In: Journal of Psychiatric Research. 55, p. 77-86 10 p.

Research output: Contribution to journal › Journal article › peer-review

Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 24/07/2014, In: Nature. 511, 7510, p. 421-427 7 p.

Research output: Contribution to journal › Journal article › peer-review

Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain

Gagliano, S. A., Tiwari, A. K., Freeman, N., Lieberman, J. A., Meltzer, H. Y., Kennedy, J. L., Knight, J. & Müller, D. J., 07/2014, In: Human Psychopharmacology: Clinical and Experimental. 29, 4, p. 330-335 6 p.

Research output: Contribution to journal › Journal article › peer-review

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

Navarini, A. A., Simpson, M. A., Weale, M., Knight, J., Carlavan, I., Reiniche, P., Burden, D. A., Layton, A., Bataille, V., Allen, M., Pleass, R., Pink, A., Creamer, D., English, J., Munn, S., Walton, S., Willis, C., Déret, S., Voegel, J. J., Spector, T. & 4 others, Smith, C. H., Trembath, R. C., Barker, J. N. W. N. & Acne Genetic Study Group, 13/06/2014, In: Nature Communications. 5, 6 p., 4020.

Research output: Contribution to journal › Journal article › peer-review

A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization

Gagliano, S. A., Barnes, M. R., Weale, M. E. & Knight, J., 20/05/2014, In: PLoS ONE. 9, 5, 14 p., e98122.

Research output: Contribution to journal › Journal article › peer-review

Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1

Xu, W., Cohen-Woods, S., Chen, Q., Noor, A., Knight, J., Hosang, G., Parikh, S. V., De Luca, V., Tozzi, F., Muglia, P., Forte, J., McQuillin, A., Hu, P., Gurling, H. M. D., Kennedy, J. L., McGuffin, P., Farmer, A., Strauss, J. & Vincent, J. B., 4/01/2014, In: Journal of Medical Genetics. 15, 13 p., 2.

Research output: Contribution to journal › Journal article › peer-review

Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis

Knight, J., Spain, S. L., Capon, F., Hayday, A., Nestle, F. O., Clop, A., Barker, J. N. W. N., Weale, M. E., Trembath, R. C. & Wellcome Trust Case Control Consortium, 1/12/2012, In: Human Molecular Genetics. 21, 23, p. 5185-5192 8 p.

Research output: Contribution to journal › Journal article › peer-review

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Tsoi, L. C., Spain, S. L., Knight, J., Ellinghaus, E., Stuart, P. E., Capon, F., Ding, J., Li, Y., Tejasvi, T., Gudjonsson, J. E., Kang, H. M., Allen, M. H., McManus, R., Novelli, G., Samuelsson, L., Schalkwijk, J., Ståhle, M., Burden, A. D., Smith, C. H., Cork, M. J. & 31 others, Estivill, X., Bowcock, A. M., Krueger, G. G., Weger, W., Worthington, J., Tazi-Ahnini, R., Nestle, F. O., Hayday, A., Hoffmann, P., Winkelmann, J., Wijmenga, C., Langford, C., Edkins, S., Andrews, R., Blackburn, H., Strange, A., Band, G., Pearson, R. D., Vukcevic, D., Spencer, C. C. A., Deloukas, P., Mrowietz, U., Schreiber, S., Weidinger, S., Koks, S., Kingo, K., Esko, T., Metspalu, A., Lim, H. W., Voorhees, J. J. & Collaborative Association Study of Psoriasis (CASP), 12/2012, In: Nature Genetics. 44, 12, p. 1341-1348 8 p.

Research output: Contribution to journal › Letter › peer-review

Introduction to genetic association studies

Lewis, C. M. & Knight, J., 03/2012, In: Cold Spring Harbor Protocols. 2012, 3, p. 297-306 10 p.

Research output: Contribution to journal › Journal article › peer-review

Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis

Onoufriadis, A., Simpson, M. A., Pink, A. E., Di Meglio, P., Smith, C. H., Pullabhatla, V., Knight, J., Spain, S. L., Nestle, F. O., Burden, A. D., Capon, F., Trembath, R. C. & Barker, J. N. W. N., 9/09/2011, In: American Journal of Human Genetics. 89, 3, p. 432-437 6 p.

Research output: Contribution to journal › Journal article › peer-review

A genome-wide significant linkage for severe depression on chromosome 3: the depression network study

Breen, G., Webb, B. T., Butler, A. W., van den Oord, E. J. C. G., Tozzi, F., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M. J., Cohen-Woods, S., Perry, J., Galwey, N. W., Upmanyu, R., Craig, I., Lewis, C. M., Ng, M., Brewster, S. & 8 others, Preisig, M., Rietschel, M., Jones, L., Knight, J., Rice, J., Muglia, P., Farmer, A. E. & McGuffin, P., 08/2011, In: American Journal of Psychiatry. 168, 8, p. 840-847 8 p.

Research output: Contribution to journal › Journal article › peer-review

Using functional annotation for the empirical determination of Bayes Factors for genome-wide association study analysis

Knight, J., Barnes, M. R., Breen, G. & Weale, M. E., 27/04/2011, In: PLoS ONE. 6, 4, 8 p., e14808.

Research output: Contribution to journal › Journal article › peer-review

Common variants in DGKK are strongly associated with risk of hypospadias

van der Zanden, L. F. M., van Rooij, I. A. L. M., Feitz, W. F. J., Knight, J., Donders, A. R. T., Renkema, K. Y., Bongers, E. M. H. F., Vermeulen, S. H. H. M., Kiemeney, L. A. L. M., Veltman, J. A., Arias-Vásquez, A., Zhang, X., Markljung, E., Qiao, L., Baskin, L. S., Nordenskjöld, A., Roeleveld, N., Franke, B. & Knoers, N. V. A. M., 01/2011, In: Nature Genetics. 43, 1, p. 48-50 3 p.

Research output: Contribution to journal › Letter › peer-review

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

Strange, A., Capon, F., Spencer, C. C. A., Knight, J., Weale, M. E., Allen, M. H., Barton, A., Band, G., Bellenguez, C., Bergboer, J. G. M., Blackwell, J. M., Bramon, E., Bumpstead, S. J., Casas, J. P., Cork, M. J., Corvin, A., Deloukas, P., Dilthey, A., Duncanson, A., Edkins, S. & 31 others, Estivill, X., Fitzgerald, O., Freeman, C., Giardina, E., Gray, E., Hofer, A., Hüffmeier, U., Hunt, S. E., Irvine, A. D., Jankowski, J., Kirby, B., Langford, C., Lascorz, J., Leman, J., Leslie, S., Mallbris, L., Markus, H. S., Mathew, C. G., McLean, W. H. I., McManus, R., Mössner, R., Moutsianas, L., Naluai, A. T., Nestle, F. O., Novelli, G., Onoufriadis, A., Palmer, C. N. A., Perricone, C., Pirinen, M., Plomin, R. & Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, 11/2010, In: Nature Genetics. 42, 11, p. 985-990 6 p.

Research output: Contribution to journal › Letter › peer-review

An investigation of candidate regions for association with bipolar disorder

Knight, J., Rochberg, N. S., Saccone, S. F., Nurnberger, J. I., Rice, J. P. & NIMH Genetics Initiative Bipolar Disorder Consortium, 5/10/2010, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 153B, 7, p. 1292-1297 6 p.

Research output: Contribution to journal › Journal article › peer-review

The Bipolar Association Case-Control Study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

Cohen-Woods, S., Craig, I., Gaysina, D., Gray, J., Gunasinghe, C., Craddock, N., Elkin, A., Jones, L., Kennedy, J., King, N., Korszun, A., Knight, J., Owen, M., Parikh, S., Strauss, J., Sterne, A., Tozzi, F., Perry, J., Muglia, P., Vincent, J. & 2 others, McGuffin, P. & Farmer, A., 5/10/2010, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 153B, 7, p. 1298-1304 7 p.

Research output: Contribution to journal › Journal article › peer-review

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders

Beall, C. M., Cavalleri, G. L., Deng, L., Elston, R. C., Gao, Y., Knight, J., Li, C., Li, J. C., Liang, Y., McCormack, M., Montgomery, H. E., Pan, H., Robbins, P. A., Shianna, K. V., Tam, S. C., Tsering, N., Veeramah, K. R., Wang, W., Wangdui, P., Weale, M. E. & 9 others, Xu, Y., Xu, Z., Yang, L., Zaman, M. J., Zeng, C., Zhang, L., Zhang, X., Zhaxi, P. & Zheng, Y. T., 22/06/2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11459-11464 6 p.

Research output: Contribution to journal › Journal article › peer-review

Software for generating liability distributions for pedigrees conditional on their observed disease states and covariates

Campbell, D. D., Sham, P. C., Knight, J., Wickham, H. & Landau, S., 02/2010, In: Genetic Epidemiology. 34, 2, p. 159-170 12 p.

Research output: Contribution to journal › Journal article › peer-review

Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder

Cohen-Woods, S., Gaysina, D., Craddock, N., Farmer, A., Gray, J., Gunasinghe, C., Hoda, F., Jones, L., Knight, J., Korszun, A., Owen, M. J., Sterne, A., Craig, I. W. & McGuffin, P., 15/04/2009, In: Human Molecular Genetics. 18, 8, p. 1504-1509 6 p.

Research output: Contribution to journal › Journal article › peer-review