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Professor Joanne Knight

Chair in Applied Data Science

  1. 2016
  2. Published

    Genetic association analysis of N-methyl-d-aspartate receptor subunit gene GRIN2B and clinical response to clozapine

    Taylor, D. L., Tiwari, A. K., Lieberman, J. A., Potkin, S. G., Meltzer, H. Y., Knight, J., Remington, G., Müller, D. J. & Kennedy, J. L., 03/2016, In: Human Psychopharmacology: Clinical and Experimental. 31, 2, p. 121-134 14 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  3. Published

    Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2016, In: Nature Reviews Neuroscience. 19, 3, p. 420-431 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  4. Published

    Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2016, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 171B, 2, p. 276-89 14 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  5. Published

    Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 16/02/2016, In: Frontiers in Genetics. 7, 13 p., 15.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  6. Published

    Schizophrenia risk from complex variation of complement component 4

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 11/02/2016, In: Nature. 530, 7589, p. 177-183 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  7. Published

    IBD genetic risk profile in healthy first-degree relatives of Crohn's disease patients

    Kevans, D., Silverberg, M. S., Borowski, K., Griffiths, A., Xu, W., Onay, V., Paterson, A. D., Knight, J., Croitoru, K. & GEM Project, 02/2016, In: Journal of Crohn's and Colitis. 10, 2, p. 209-215 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  8. Published

    Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS

    Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium, 01/2016, In: PLoS Genetics. 12, 1, 22 p., e1005803.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  9. 2015
  10. Published

    Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

    Schizophrenia Working Group of Psychiatric Genomics Consortium, 12/2015, In: Nature Genetics. 47, 12, p. 1385-1392 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  11. Published

    Modeling linkage disequilibrium increases accuracy of polygenic risk scores

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study, 1/10/2015, In: American Journal of Human Genetics. 97, 4, p. 576-592 17 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  12. Published

    Predictors of outcome in ulcerative colitis

    Waterman, M., Knight, J., Dinani, A., Xu, W., Stempak, J. M., Croitoru, K., Nguyen, G. C., Cohen, Z., McLeod, R. S., Greenberg, G. R., Steinhart, A. H. & Silverberg, M. S., 09/2015, In: Inflammatory Bowel Diseases. 21, 9, p. 2097-2105 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  13. Published

    Smoking gun or circumstantial evidence? comparison of statistical learning methods using functional annotations for prioritizing risk variants

    Gagliano, S. A., Ravji, R., Barnes, M. R., Weale, M. E. & Knight, J., 24/08/2015, In: Scientific Reports. 5, 11 p., 13373.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  14. Published

    Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models

    Lobo, D. S. S., Aleksandrova, L., Knight, J., Casey, D. M., el-Guebaly, N., Nobrega, J. N. & Kennedy, J. L., 08/2015, In: Molecular Psychiatry. 20, 8, p. 1002-1010 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  15. Published

    A genome-wide association study of suicide severity scores in bipolar disorder

    Zai, C. C., Gonçalves, V. F., Tiwari, A. K., Gagliano, S. A., Hosang, G., de Luca, V., Shaikh, S. A., King, N., Chen, Q., Xu, W., Strauss, J., Breen, G., Lewis, C. M., Farmer, A. E., McGuffin, P., Knight, J., Vincent, J. B. & Kennedy, J. L., 06/2015, In: Journal of Psychiatric Research. 65, p. 23-29 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  16. Published

    Assessing models for genetic prediction of complex traits: a comparison of visualization and quantitative methods

    Gagliano, S. A., Paterson, A. D., Weale, M. E. & Knight, J., 22/05/2015, In: BMC Genomics. 16, 11 p., 405.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  17. Published

    Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

    Tsoi, L. C., Spain, S. L., Ellinghaus, E., Stuart, P. E., Capon, F., Knight, J., Tejasvi, T., Kang, H. M., Allen, M. H., Lambert, S., Stoll, S. W., Weidinger, S., Gudjonsson, J. E., Koks, S., Kingo, K., Esko, T., Das, S., Metspalu, A., Weichenthal, M., Enerback, C., & 13 othersKrueger, G. G., Voorhees, J. J., Chandran, V., Rosen, C. F., Rahman, P., Gladman, D. D., Reis, A., Nair, R. P., Franke, A., Barker, J. N. W. N., Abecasis, G. R., Trembath, R. C. & Elder, J. T., 5/05/2015, In: Nature Communications. 6, 8 p., 7001.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  18. Published

    LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2015, In: Nature Genetics. 47, 3, p. 291-295 5 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  19. Published

    Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes

    Prescott, N. J., Lehne, B., Stone, K., Lee, J. C., Taylor, K., Knight, J., Papouli, E., Mirza, M. M., Simpson, M. A., Spain, S. L., Lu, G., Fraternali, F., Bumpstead, S. J., Gray, E., Amar, A., Bye, H., Green, P., Chung-Faye, G., Hayee, BH., Pollok, R., & 10 othersSatsangi, J., Parkes, M., Barrett, J. C., Mansfield, J. C., Sanderson, J., Lewis, C. M., Weale, M. E., Schlitt, T., Mathew, C. G. & UK IBD Genetics Consortium, 11/02/2015, In: PLoS Genetics. 11, 2, e1004955.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  20. Published

    CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers: findings from two independent populations

    Wassenaar, C. A., Ye, Y., Cai, Q., Aldrich, M. C., Knight, J., Spitz, M. R., Wu, X., Blot, W. J. & Tyndale, R. F., 01/2015, In: Carcinogenesis. 36, 1, p. 99-103 5 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  21. Published

    Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes

    Pouget, J. G., Gonçalves, V. F., Nurmi, E. L., Laughlin, C. P., Mallya, K. S., McCracken, J. T., Aman, M. G., McDougle, C. J., Scahill, L., Misener, V. L., Tiwari, A. K., Zai, C. C., Brandl, E. J., Felsky, D., Leung, A. Q., Lieberman, J. A., Meltzer, H. Y., Potkin, S. G., Niedling, C., Steimer, W., & 4 othersLeucht, S., Knight, J., Müller, D. J. & Kennedy, J. L., 01/2015, In: Pharmacogenomics. 16, 1, p. 5-22 18 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  22. 2014
  23. Published

    Complex host genetics influence the microbiome in inflammatory bowel disease

    Knights, D., Silverberg, M. S., Weersma, R. K., Gevers, D., Dijkstra, G., Huang, H., Tyler, A. D., van Sommeren, S., Imhann, F., Stempak, J. M., Huang, H., Vangay, P., Al-Ghalith, G. A., Russell, C., Sauk, J., Knight, J., Daly, M. J., Huttenhower, C. & Xavier, R. J., 2/12/2014, In: Genome Biology. 6, 12, 11 p., 107.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  24. Published

    Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 6/11/2014, In: American Journal of Human Genetics. 95, 5, p. 535-552 18 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  25. Published

    The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa

    Yilmaz, Z., Kaplan, A. S., Tiwari, A. K., Levitan, R. D., Piran, S., Bergen, A. W., Kaye, W. H., Hakonarson, H., Wang, K., Berrettini, W. H., Brandt, H. A., Bulik, C. M., Crawford, S., Crow, S., Fichter, M. M., Halmi, K. A., Johnson, C. L., Keel, P. K., Klump, K. L., Magistretti, P., & 7 othersMitchell, J., Strober, M., Thornton, L. M., Treasure, J., Woodside, D. B., Knight, J. & Kennedy, J. L., 08/2014, In: Journal of Psychiatric Research. 55, p. 77-86 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  26. Published

    Biological insights from 108 schizophrenia-associated genetic loci

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, 24/07/2014, In: Nature. 511, 7510, p. 421-427 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  27. Published

    Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain

    Gagliano, S. A., Tiwari, A. K., Freeman, N., Lieberman, J. A., Meltzer, H. Y., Kennedy, J. L., Knight, J. & Müller, D. J., 07/2014, In: Human Psychopharmacology: Clinical and Experimental. 29, 4, p. 330-335 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  28. Published

    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

    Navarini, A. A., Simpson, M. A., Weale, M., Knight, J., Carlavan, I., Reiniche, P., Burden, D. A., Layton, A., Bataille, V., Allen, M., Pleass, R., Pink, A., Creamer, D., English, J., Munn, S., Walton, S., Willis, C., Déret, S., Voegel, J. J., Spector, T., & 4 othersSmith, C. H., Trembath, R. C., Barker, J. N. W. N. & Acne Genetic Study Group, 13/06/2014, In: Nature Communications. 5, 6 p., 4020.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

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