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Dr John Worthington

Senior Lecturer in Infection Biology

  1. Published

    Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential

    Ball, S. G., Worthington, J. J., Canfield, A. E., Merry, C. L. R. & Kielty, C. M., 03/2014, In: Stem Cells. 32, 3, p. 694-705 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  2. Published

    WSX-1: a key role in induction of chronic intestinal nematode infection

    Bancroft, A. J., Humphreys, N. E., Worthington, J. J., Yoshida, H. & Grencis, R. K., 15/06/2004, In: Journal of Immunology. 172, 12, p. 7635-7641 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  3. Published

    Chronic Antipsychotic Treatment Modulates Aromatase (CYP19A1) Expression in the Male Rat Brain

    Bogus, K., Pałasz, A., Suszka-Świtek, A., Worthington, J. J., Krzystanek, M. & Wiaderkiewicz, R., 15/06/2019, In: Journal of Molecular Neuroscience . 68, 2, p. 311-317 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  4. Published

    Antipsychotics increase steroidogenic enzyme gene expression in the rat brainstem

    Bogus, K., Żarczyńska, M., Pałasz, A., Suszka-Świtek, A., Worthington, J. J., Krzystanek, M. & Żarczyński, P., 28/02/2022, In: Molecular Biology Reports. 49, 2, p. 1601-1608 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  5. Published

    Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice

    Cohen, T. S., Takahashi, V., Bonnell, J., Tovchigrechko, A., Chaerkady, R., Yu, W., Jones-Nelson, O., Lee, Y., Raja, R., Hess, S., Stover, C. K., Worthington, J. J., Travis, M. A. & Sellman, B. R., 1/05/2019, In: Journal of Clinical Investigation. 129, 5, p. 2133-2144 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  6. Published

    Helminth Sensing at the Intestinal Epithelial Barrier—A Taste of Things to Come

    Faniyi, A. A., Wijanarko, K. J., Tollitt, J. & Worthington, J. J., 30/07/2020, In: Frontiers in Immunology. 11, 8 p., 1489.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  7. Published

    Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

    Fenton, T. M., Kelly, A., Shuttleworth, E. E., Smedley, C., Atakilit, A., Powrie, F., Campbell, S., Nishimura, S. L., Sheppard, D., Levison, S., Worthington, J. J., Lehtinen, M. J. & Travis, M. A., 2017, In: Mucosal Immunology. 10, 3, p. 624-634 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  8. Published

    Tuft cells: a new flavor in innate epithelial immunity

    Grencis, R. K. & Worthington, J. J., 08/2016, In: Trends in Parasitology. 32, 8, p. 583-585 3 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  9. Published

    Effects of radio-frequency fields on bacterial cell membranes and nematode temperature-sensitive mutants

    Gul Guven, R., Guven, K., Dawe, A., Worthington, J., Harvell, C., Popple, A., Smith, T., Smith, B. & de Pomerai, D. I., 2/08/2006, In: Enzyme and Microbial Technology. 39, 4, p. 788-795 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  10. Published

    Chronic Trichuris muris infection in C57BL/6 mice causes significant changes in most microbiota and metabolome: effects reversed by pathogen clearance

    Houlden, A., Hayes, K. S., Bancroft, A. J., Worthington, J. J., Wang, P., Grencis, R. K. & Roberts, I. S., 2015, In: PLoS ONE. 10, 5, 25 p., e0125945.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  11. Published

    The role of CD8+ cells in the establishment and maintenance of a Trichuris muris infection

    Humphreys, N. E., Worthington, J. J., Little, M. C., Rice, E. J. & Grencis, R. K., 04/2004, In: Parasite Immunology. 26, 4, p. 187-196 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  12. Published

    Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro

    Ilic, N., Worthington, J. J., Gruden-Movsesijan, A., Travis, M. A., Sofronic-Milosavljevic, L. & Grencis, R. K., 10/2011, In: Parasite Immunology. 33, 10, p. 572-582 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  13. Published

    Effects of long-term treatment with the neuroleptics haloperidol, clozapine and olanzapine on immunoexpression of NMDA receptor subunits NR1, NR2A and NR2B in the rat hippocampus

    Krzystanek, M., Bogus, K., Pałasz, A., Krzystanek, E., Worthington, J. J. & Wiaderkiewicz, R., 10/2015, In: Pharmacological reports : PR. 67, 5, p. 965-969 5 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  14. Published

    Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon

    Krzystanek, M., Bogus, K., Palasz, A., Wiaderkiewicz, A., Filipczyk, L., Rojczyk, E., Worthington, J. J. & Wiaderkiewicz, R., 10/2016, In: Pharmacological reports : PR. 68, 5, p. 990-995 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  15. Published

    Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone

    Lasut, B., Palasz, A., Filipczyk, L., Arias-Carrión, O., Rojczyk, E., Savchyna, M., Bogus, K., Worthington, J. J., Krzystanek, M. & Wiaderkiewicz, R., 2018, In: CNS & neurological disorders drug targets. 17, 6, p. 458-463 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  16. Published

    Seasonal changes in peptide, receptor and ion channel mRNA expression in the caudal neurosecretory system of the European flounder (Platichthys flesus)

    Lu, W., Worthington, J., Riccardi, D., Balment, R. J. & McCrohan, C. R., 15/06/2007, In: General and Comparative Endocrinology. 153, 1-3, p. 262-272 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  17. Published

    Molecular characterization and expression of urotensin II and its receptor in the flounder (Platichthys flesus): a hormone system supporting body fluid homeostasis in euryhaline fish

    Lu, W., Greenwood, M., Dow, L., Yuill, J., Worthington, J., Brierley, M. J., McCrohan, C. R., Riccardi, D. & Balment, R. J., 08/2006, In: Clinical Endocrinology. 147, 8, p. 3692-708 17 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  18. Published

    Enteroendocrine cells: neglected players in gastrointestinal disorders?

    Moran, G. W., Leslie, F. C., Levison, S. E., Worthington, J. & McLaughlin, J. T., 07/2008, In: Therapeutic Advances in Gastroenterology. 1, 1, p. 51-60 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  19. Published

    Long-term treatment with haloperidol affects neuropeptide S and NPSR mRNA levels in the rat brain

    Palasz, A., Rojczyk, E., Golyszny, M., Filipczyk, L., Worthington, J. J. & Wiaderkiewicz, R., 04/2016, In: Acta Neuropsychiatrica. 28, 2, p. 110-116 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  20. Published

    Nesfatin-1, a unique regulatory neuropeptide of the brain

    Palasz, A., Krzystanek, M., Worthington, J., Czajkowska, B., Kostro, K., Wiaderkiewicz, R. & Bajor, G., 06/2012, In: Neuropeptides. 46, 3, p. 105-112 8 p.

    Research output: Contribution to Journal/MagazineLiterature reviewpeer-review

  21. Published

    Escitalopram affects spexin expression in the rat hypothalamus, hippocampus and striatum

    Palasz, A., Suszka-Świtek, A., Filipczyk, L., Bogus, K., Rojczyk, E., Worthington, J. J., Krzystanek, M. & Wiaderkiewicz, R., 12/2016, In: Pharmacological reports : PR. 68, 6, p. 1326-1331 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  22. Published

    Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

    Palasz, A., Palka, M., Filipczyk, L., Castro Menezes, I., Rojczyk, E., Worthington, J. J., Piwowarczyk-Nowak, A., Krzystanek, M. & Wiaderkiewicz, R., 07/2018, In: Journal of Neural Transmission. 125, 7, p. 1099-1105 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  23. Published

    The novel neuropeptide phoenixin is highly co-expressed with nesfatin-1 in the rat hypothalamus, an immunohistochemical study

    Pałasz, A., Rojczyk, E., Bogus, K., Worthington, J. J. & Wiaderkiewicz, R., 10/04/2015, In: Neuroscience Letters. 592, p. 17-21 5 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  24. Published

    The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa

    Pałasz, A., Janas-Kozik, M., Borrow, A., Arias-Carrión, O. & Worthington, J. J., 02/2018, In: Neurochemistry International. 113, p. 120-136 17 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  25. Published

    A different ultrastructural face of ribbon synapses in the rat retina

    Pałasz, A., Mielańczyk, Ł., Matysiak, N., Segovia, Y., Savchyna, M., Mordecka-Chamera, K. & Worthington, J. J., 12/2018, In: Anatomia, Histologia, Embryologia. 47, 6, p. 613-617 5 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  26. E-pub ahead of print

    The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis

    Pałasz, A., Bogus, K., Suszka-Świtek, A., Kaśkosz, A., Saint-Remy, S., Piwowarczyk-Nowak, A., Filipczyk, Ł., Worthington, J. J., Mordecka-Chamera, K., Kostro, K., Bajor, G. & Wiaderkiewicz, R., 15/02/2019, (E-pub ahead of print) In: Journal of Neural Transmission. 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  27. Published

    Molecular neurochemistry of the lanthanides

    Pałasz, A., Segovia, Y., Skowronek, R. & Worthington, J. J., 1/09/2019, In: Synapse. 73, 9, 14 p., e22119.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  28. Published

    Escitalopram as a modulator of proopiomelanocortin, kisspeptin, Kiss1R and MCHR1 gene expressions in the male rat brain

    Pałasz, A., Piwowarczyk-Nowak, A., Suszka-Świtek, A., Bogus, K., Filipczyk, Ł., Vecchia, A. D., Mordecka-Chamera, K., Menezes, I. C., Worthington, J. J., Krzystanek, M. & Wiaderkiewicz, R., 1/10/2020, In: Molecular Biology Reports. 47, p. 8273–8278 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  29. Published

    Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus

    Pałasz, A., Suszka-Świtek, A., Kaśkosz, A., Plewka, D., Bogus, K., Filipczyk, Ł., Błaszczyk, I., Bacopoulou, F., Worthington, J. J., Piwowarczyk-Nowak, A., Tyszkiewicz-Nwafor, M. & Wiaderkiewicz, R., 1/01/2021, In: Journal of Chemical Neuroanatomy. 111, 6 p., 101883.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  30. Published

    The role of brain gaseous neurotransmitters in anxiety

    Pałasz, A., Menezes, I. C. & Worthington, J. J., 13/03/2021, In: Pharmacological reports : PR. 73, p. 357–371 15 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  31. Published

    Olanzapine increases neural chemorepulsant-draxin expression in the adult rat hippocampus

    Pałasz, A., Suszka-Świtek, A., Francikowski, J., Krzystanek, M., Bogus, K., Skałbania, J., Worthington, J. J. & Mrzyk, I., 27/03/2021, In: Pharmaceuticals. 14, 4, 8 p., 298.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  32. Published

    Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem

    Pałasz, A., Żarczyński, P., Bogus, K., Mordecka-Chamera, K., Della Vecchia, A., Skałbania, J., Worthington, J. J., Krzystanek, M. & Żarczyńska, M., 31/08/2021, In: Pharmacological reports : PR. 73, 4, p. 1188-1194 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  33. Published

    Neuropeptides of the human magnocellular hypothalamus

    Pałasz, A., Della Vecchia, A., Saganiak, K. & Worthington, J. J., 30/11/2021, In: Journal of Chemical Neuroanatomy. 117, 13 p., 102003.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  34. Published

    Immunogenicity and Protective Efficacy of an Intranasal Live-attenuated Vaccine Against SARS-CoV-2

    Park, J-G., Oladunni, F. S., Rohaim, M. A., Whittingham-Dowd, J., Tollitt, J., Hodges, M. D. J., Fathallah, N., Assas, M. B., Alhazmi, W., Almilaibary, A., Iqbal, M., Chang, P., Escalona, R., Shivanna, V., Torrelles, J. B., Worthington, J. J., Jackson-Jones, L. H., Martinez-Sobrido, L. & Munir, M., 30/09/2021, In: iScience. 24, 9, 102941.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  35. Published

    Escitalopram alters local expression of noncanonical stress-related neuropeptides in the rat brain via NPS receptor signaling

    Piwowarczyk-Nowak, A., Pałasz, A., Suszka-Świtek, A., Della Vecchia, A., Grajoszek, A., Krzystanek, M. & Worthington, J. J., 31/08/2022, In: Pharmacological reports : PR. 74, 4, p. 637-653 17 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  36. Published

    Effect of Escitalopram on the Number of DCX-Positive Cells and NMUR2 Receptor Expression in the Rat Hippocampus under the Condition of NPSR Receptor Blockade

    Piwowarczyk-Nowak, A., Pałasz, A., Suszka-Świtek, A., Błaszczyk, I., Bogus, K., Łasut-Szyszka, B., Krzystanek, M. & Worthington, J. J., 20/05/2022, In: Pharmaceuticals. 15, 5, 14 p., 631.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  37. Published

    Modulatory effect of long-term treatment with escitalopram and clonazepam on the expression of anxiety-related neuropeptides: neuromedin U, neuropeptide S and their receptors in the rat brain

    Piwowarczyk-Nowak, A., Pałasz, A., Bogus, K., Krzystanek, M., Błaszczyk, I., Worthington, J. J. & Grajoszek, A., 30/09/2022, In: Molecular Biology Reports. 49, 9, p. 9041-9049 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  38. Published

    Neurolight -astonishing advances in brain imaging

    Rojczyk-Gołębiewska, E., Pałasz, A., Worthington, J. J., Markowski, G. & Wiaderkiewicz, R., 02/2015, In: The International Journal of Neuroscience. 125, 2, p. 91-99 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  39. Published

    Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone

    Skałbania, J., Pałasz, A., Błaszczyk, I., Suszka-Świtek, A., Krzystanek, M., Tulcanaz, K. P., Worthington, J. J. & Mordecka-Chamera, K., 31/08/2021, In: Pharmacological reports : PR. 73, 4, p. 1164-1169 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  40. Published

    TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice

    Steel, N., Faniyi, A., Rahman, S., Swietlik, S., Czajkowska, B. I., Chan, B., Hardgrave, A., Steel, A., Sparwasser, T., Assas, M., Grencis, R. K., Travis, M. A. & Worthington, J. J., 18/04/2019, In: PLoS Pathogens. 15, 4, 25 p., e1007657.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  41. E-pub ahead of print

    The GnRH analogues affect novel neuropeptide SMIM20/phoenixin and GPR173 receptor expressions in the female rat hypothalamic-pituitary-gonadal (HPG) axis

    Suszka-Świtek, A., Pałasz, A., Filipczyk, Ł., Menezes, I. C., Mordecka-Chamera, K., Angelone, T., Bogus, K., Bacopoulou, F., Worthington, J. J. & Wiaderkiewicz, R., 4/01/2019, (E-pub ahead of print) In: Clinical and Experimental Pharmacology and Physiology.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  42. Published

    The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease

    Worthington, J. J., 3/08/2015, In: Biochemical Society Transactions. 43, 4, p. 727-733 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  43. Published

    Effector Tregs: middle-men in TGFβ activation

    Worthington, J. J. & Travis, M. A., 27/06/2015, In: Oncotarget. 6, 24, p. 19958-19959 2 p.

    Research output: Contribution to Journal/MagazineEditorialpeer-review

  44. Published

    Integrin αvβ8-mediated TGF-β activation by effector regulatory T sells is essential for suppression of T-Cell-mediated inflammation

    Worthington, J. J., Kelly, A., Smedley, C., Bauché, D., Campbell, S., Marie, J. C. & Travis, M. A., 19/05/2015, In: Immunity. 42, 5, p. 903-915 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  45. Published

    Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity

    Worthington, J. J., Klementowicz, J. E., Rahman, S., Czajkowska, B. I., Smedley, C., Waldmann, H., Sparwasser, T., Grencis, R. K. & Travis, M. A., 2013, In: PLoS Pathogens. 9, 10, 12 p., e1003675.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  46. Published

    Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion

    Worthington, J. J., Samuelson, L. C., Grencis, R. K. & McLaughlin, J. T., 17/01/2013, In: PLoS Pathogens. 9, 1, 8 p., e1003122.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  47. Published

    Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells

    Worthington, J. J., Fenton, T. M., Czajkowska, B. I., Klementowicz, J. E. & Travis, M. A., 12/2012, In: Immunobiology. 217, 12, p. 1259-1265 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  48. Published

    Intestinal dendritic cells specialize to activate transforming growth factor-β and induce Foxp3+ regulatory T cells via integrin αvβ8

    Worthington, J. J., Czajkowska, B. I., Melton, A. C. & Travis, M. A., 11/2011, In: Gastroenterology. 141, 5, p. 1802-1812 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  49. Published

    TGFβ: a sleeping giant awoken by integrins

    Worthington, J. J., Klementowicz, J. E. & Travis, M. A., 01/2011, In: Trends in Biochemical Sciences. 36, 1, p. 47-54 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  50. Published

    Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

    Worthington, J. J., Reimann, F. & Gribble, F. M., 01/2018, In: Mucosal Immunology. 11, p. 3-20 18 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

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