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Dr Leonie Unterholzner

Senior Lecturer in Molecular Immunology

  1. Published

    Beyond sensing DNA: A role for cGAS in the detection of extracellular cyclic di-nucleotides

    Unterholzner, L., 1/04/2019, In: EMBO Reports. 20, 4, e47970.

    Research output: Contribution to Journal/MagazineJournal article

  2. Published

    Camouflage and interception: How pathogens evade detection by intracellular nucleic acid sensors

    Unterholzner, L. & Almine, J. F., 03/2019, In: Immunology. 156, 3, p. 217-227 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  3. Published

    cGAS-independent STING activation in response to DNA damage

    Unterholzner, L. & Dunphy, G., 19/04/2019, In: Molecular & Cellular Oncology. 6, 4, 3 p., e1558682 .

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  4. Published

    DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS-STING signalling

    Wheeler, O. P. G. & Unterholzner, L., 28/09/2023, In: Essays in Biochemistry. 67, 6, p. 905-918 14 p.

    Research output: Contribution to Journal/MagazineReview articlepeer-review

  5. Published

    IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

    Almine, J. F., O'Hare, C. A. J., Dunphy, G., Haga, I. R., Naik, R. J., Atrih, A., Connolly, D. J., Taylor, J., Kelsall, I. R., Bowie, A. G., Beard, P. M. & Unterholzner, L., 13/02/2017, In: Nature Communications. 8, 14392.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  6. Published

    IFI16 is an innate immune sensor for intracellular DNA

    Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., Fitzgerald, K. A., Paludan, S. R. & Bowie, A. G., 11/2010, In: Nature Immunology. 11, 11, p. 997-1004 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  7. Published

    Innate DNA sensing moves to the nucleus

    Unterholzner, L. & Bowie, A. G., 19/05/2011, In: Cell Host and Microbe. 9, 5, p. 351-353 3 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  8. Published

    Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex

    Bono, F., Ebert, J., Unterholzner, L., Güttler, T., Izaurralde, E. & Conti, E., 03/2004, In: EMBO Reports. 5, 3, p. 304-310 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  9. Published

    Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7

    Gu, L., Casserly, D., Brady, G., Carpenter, S., Bracken, A. P., Fitzgerald, K. A., Unterholzner, L. & Bowie, A. G., 10/01/2022, In: Nature Communications. 13, 1, 14 p., 14.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  10. Published

    Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signalling after nuclear DNA damage

    Dunphy, G., Flannery, S., Almine, J., Connolly, D., Paulus, C., Jønsson, K., Jakobsen, M., Nevels, M., Bowie, A. & Unterholzner, L., 6/09/2018, In: Molecular Cell. 71, 5, p. 745-760 16 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

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