A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

Raimi, O. G., Hurtado-Guerrero, R., Borodkin, V., Ferenbach, A., Urbaniak, M., Ferguson, M. A. J. & van Aalten, D. M. F., 24/03/2020, (E-pub ahead of print) In: RSC Chemical Biology. 2020, 1, p. 13-25 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology

Durrant, J. D., Amaro, R. E., Xie, L., Urbaniak, M. D., Ferguson, M. A. J., Haapalainen, A., Chen, Z., Di Guilmi, A. M., Wunder, F., Bourne, P. E. & McCammon, J. A., 22/01/2010, In: PLoS Computational Biology. 6, 1, 8 p., e1000648.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei.

Urbaniak, M., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Hopkins Navratilova, I., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20/09/2013, In: ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A transferrin receptor’s guide to African trypanosomes

Urbaniak, M. & Gadelha, C., 31/12/2023, In: The Cell Surface. 9, 3 p., 100100.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

Urbaniak, M. D., 08/2009, In: Molecular and Biochemical Parasitology. 166, 2, p. 183-185 3 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cell cycle synchronisation of Trypanosoma brucei by centrifugal counter-flow elutriation reveals the timing of nuclear and kinetoplast DNA replication

Benz, C., Dondelinger, F., McKean, P. G. & Urbaniak, M. D., 14/12/2017, In: Scientific Reports. 7, 10 p., 17599.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Chapter 3 The GlcNAc-PI de-N-acetylase. Structure, function, and activity

Urbaniak, M. D. & Ferguson, M. A. J., 1/12/2009, In: Enzymes. 26, C, p. 49-64 16 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei

Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G., 16/11/2012, In: ACS Chemical Biology. 7, 11, p. 1858-1865 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore

Urbaniak, M. D., Frost, L. M., Bingham, J. P., Kelland, L. R., Hartley, J. A., Woolfson, D. N. & Caddick, S., 16/06/2003, In: Bioorganic and Medicinal Chemistry Letters. 13, 12, p. 2025-2027 3 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Chromosome-Scale Assembly of the Complete Genome Sequence of Leishmania (Mundinia) enriettii, Isolate CUR178, Strain LV763

Almutairi, H., Urbaniak, M. D., Bates, M. D., Thomaz-Soccol, V., Al-Salem, W. S., Dillon, R. J., Bates, P. A. & Gatherer, D., 9/09/2021, In: Microbiology Resource Announcements. 10, 36, 3 p., e0057521.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Chromosome-Scale Assembly of the Complete Genome Sequence of Leishmania (Mundinia) martiniquensis, Isolate LSCM1, Strain LV760

Almutairi, H., Urbaniak, M. D., Bates, M. D., Jariyapan, N., Al-Salem, W. S., Dillon, R. J., Bates, P. A. & Gatherer, D., 17/06/2021, In: Microbiology Resource Announcements. 10, 24, 3 p., e0005821.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Chromosome-Scale Assembly of the Complete Genome Sequence of Leishmania (Mundinia) orientalis, Isolate LSCM4, Strain LV768

Almutairi, H., Urbaniak, M. D., Bates, M. D., Jariyapan, N., Al-Salem, W. S., Dillon, R. J., Bates, P. A. & Gatherer, D., 9/09/2021, In: Microbiology Resource Announcements. 10, 36, 3 p., e0057421.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Chromosome-Scale Assembly of the Complete Genome Sequence of Leishmania (Mundinia) procaviensis Isolate 253, Strain LV425

Almutairi, H., Urbaniak, M. D., Bates, M. D., Kwakye-Nuako, G., Al-Salem, W. S., Dillon, R. J., Bates, P. A. & Gatherer, D., 18/04/2023, In: Microbiology Resource Announcements. 12, 4, 3 p., e0130622.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Chromosome-Scale Assembly of the Complete Genome Sequence of Leishmania (Mundinia) sp. Ghana, Isolate GH5, Strain LV757

Almutairi, H., Urbaniak, M. D., Bates, M. D., Kwakye-Nuako, G., Al-Salem, W. S., Dillon, R. J., Bates, P. A. & Gatherer, D., 30/09/2021, In: Microbiology Resource Announcements. 10, 39, 3 p., e0059121.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Chromosome-Scale Assembly of the Complete Genome Sequence of Porcisia hertigi, Isolate C119, Strain LV43

Almutairi, H., Urbaniak, M. D., Bates, M. D., Al-Salem, W. S., Dillon, R. J., Bates, P. A. & Gatherer, D., 14/10/2021, In: Microbiology Resource Announcements. 10, 41, 3 p., e0065121.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae

Almutairi, H., Urbaniak, M. D., Bates, M. D., Jariyapan, N., Kwakye-Nuako, G., Thomaz Soccol, V., Al-Salem, W. S., Dillon, R. J., Bates, P. A. & Gatherer, D., 6/09/2021, In: Scientific Data. 8, 1, 9 p., 234.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

Urbaniak, M., Guther, M. L. S. & Ferguson, M. A. J., 4/05/2012, In: PLoS ONE. 7, 5, 8 p., e36619.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness

Durrant, J. D., Urbaniak, M. D., Ferguson, M. A. J. & McCammon, J. A., 8/07/2010, In: Journal of Medicinal Chemistry. 53, 13, p. 5025-5032 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S., & 12 othersBerriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 25/07/2018, In: Nature. 560, p. 192-197 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin

Urbaniak, M. D., Bingham, J. P., Hartley, J. A., Woolfson, D. N. & Caddick, S., 9/09/2004, In: Journal of Medicinal Chemistry. 47, 19, p. 4710-4715 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Development of chemical proteomics for the folateome and analysis of the kinetoplastid folateome

Webster, L. A., Thomas, M., Urbaniak, M. D., Wyllie, S., Ong, H. B., Tinti, M., Fairlamb, A. H., Boesche, M., Ghidelli-Disse, S., Drewes, G. & Gilbert, I. H., 12/10/2018, In: ACS Infectious Diseases. 4, 10, p. 1475-1486 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Dynamic regulation of the Trypanosoma brucei transferrin receptor in response to iron starvation is mediated via the 3’UTR

Benz, C., Lo, W., Fathallah, N., Connor-Guscott, A., Benns, H. J. & Urbaniak, M. D., 31/12/2018, In: PLoS ONE. 13, 12, 12 p., e0206332.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Extensive Translational Regulation through the Proliferative Transition of Trypanosoma cruzi Revealed by Multi-Omics

Chavez, S., Urbaniak, M., Benz, C., Smircich, P., Garat, B., Sotelo-Silveira, J. R. & Duhagon, M. A., 1/09/2021, In: mSphere. 6, 5, 21 p., e00366-21.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

Ivanova, I. M., Nepogodiev, S. A., Saalbach, G., O'Neill, E. C., Urbaniak, M. D., Ferguson, M. A. J., Gurcha, S. S., Besra, G. S. & Field, R. A., 13/01/2017, In: Carbohydrate Research. 438, p. 26-38 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

Urbaniak, M. D., Capes, A. S., Crossman, A., O'Neill, S., Thompson, S., Gilbert, I. H. & Ferguson, M. A. J., 31/03/2014, In: Carbohydrate Research. 387, p. 54-58 5 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review