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Professor Mick Urbaniak

Personal Chair

  1. 2015
  2. Published

    Molecular control of irreversible bistability during trypanosome developmental commitment

    Domingo Sananes, M. R., Szoor, B., Ferguson, M. A. J., Urbaniak, M. & Matthews, K. R., 19/10/2015, In: Journal of Cell Biology. 211, 2, p. 455-468 14 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  3. Published

    The Dictyostelium prestalk inducer differentiation-inducing factor-1 (DIF-1) triggers unexpectedly complex global phosphorylation changes

    Sugden, C., Urbaniak, M. D., Araki, T. & Williams, J. G., 15/02/2015, In: Molecular Biology of the Cell. 26, 4, p. 805-820 16 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  4. Published

    TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

    Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., de Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H. & Ferguson, M. A. J. & 21 others, Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F., 28/01/2015, In: Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  5. 2014
  6. Published

    Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

    Urbaniak, M. D., Capes, A. S., Crossman, A., O'Neill, S., Thompson, S., Gilbert, I. H. & Ferguson, M. A. J., 31/03/2014, In: Carbohydrate Research. 387, p. 54-58 5 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  7. Published

    High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics

    Güther, M. L. S., Urbaniak, M. D., Tavendale, A., Prescott, A. & Ferguson, M. A. J., 2014, In: Journal of Proteome Research. 13, 6, p. 2796-2806 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  8. Published

    Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

    Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H., 2014, In: Organic and Biomolecular Chemistry . 2014, 12, p. 1919-1934 16 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  9. Published

    Trypanosomatid Phosphoproteomics

    Urbaniak, M., 2014, Protein phosphorylation in parasites: novel targets for antiparasitic intervention. Doerig, C., Spath, G. & Wiese, M. (eds.). Chichester: Wiley Blackwell, p. 63-78 16 p. (Drug Discovery in Infectious Diseases).

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter

  10. 2013
  11. Published

    A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei.

    Urbaniak, M., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Hopkins Navratilova, I., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20/09/2013, In: ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  12. Published

    Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as a potential antifungal target

    Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Urbaniak, M., Ibrahim, A. F. M., Ferguson, M. A. J. & van Aalten, D. M. F., 08/2013, In: Molecular Microbiology. 89, 3, p. 479-493 15 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  13. Published

    Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei

    Urbaniak, M., Ferguson, M. A. J. & Martin, D. M. A., 14/03/2013, In: Journal of Proteome Research. 12, p. 2233-2244 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  14. 2012
  15. Published

    Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei

    Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G., 16/11/2012, In: ACS Chemical Biology. 7, 11, p. 1858-1865 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  16. Published

    Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

    Urbaniak, M., Guther, M. L. S. & Ferguson, M. A. J., 4/05/2012, In: PLoS ONE. 7, 5, 8 p., e36619.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  17. Published

    Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness

    Abdelwahab, N. Z., Crossman, A. T., Sullivan, L., Ferguson, M. A. J. & Urbaniak, M., 03/2012, In: Chemical Biology and Drug Design. 79, 3, p. 270-278 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  18. 2011
  19. Published

    Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

    Abdelwahab, N. Z., Urbaniak, M. D., Ferguson, M. A. J. & Crossman, A. T., 1/05/2011, In: Carbohydrate Research. 346, 6, p. 708-714 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  20. 2010
  21. Published

    Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness

    Durrant, J. D., Urbaniak, M. D., Ferguson, M. A. J. & McCammon, J. A., 8/07/2010, In: Journal of Medicinal Chemistry. 53, 13, p. 5025-5032 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  22. Published

    A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology

    Durrant, J. D., Amaro, R. E., Xie, L., Urbaniak, M. D., Ferguson, M. A. J., Haapalainen, A., Chen, Z., Di Guilmi, A. M., Wunder, F., Bourne, P. E. & McCammon, J. A., 22/01/2010, In: PLoS Computational Biology. 6, 1, 8 p., e1000648.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  23. 2009
  24. Published

    Chapter 3 The GlcNAc-PI de-N-acetylase. Structure, function, and activity

    Urbaniak, M. D. & Ferguson, M. A. J., 1/12/2009, In: Enzymes. 26, C, p. 49-64 16 p.

    Research output: Contribution to Journal/MagazineReview articlepeer-review

  25. Published

    Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

    Urbaniak, M. D., 08/2009, In: Molecular and Biochemical Parasitology. 166, 2, p. 183-185 3 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  26. 2008
  27. Published

    Probing enzymes late in the trypanosomal glycosylphosphatidylinositol biosynthetic pathway with synthetic glycosylphosphatidylinositol analogues

    Urbaniak, M. D., Yashunsky, D. V., Crossman, A., Nikolaev, A. V. & Ferguson, M. A. J., 17/10/2008, In: ACS Chemical Biology. 3, 10, p. 625-634 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  28. Published

    Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues

    Urbaniak, M. D., Crossman, A. & Ferguson, M. A. J., 08/2008, In: Chemical Biology and Drug Design. 72, 2, p. 127-132 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  29. Published

    Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

    Crossman, A. T., Urbaniak, M. D. & Ferguson, M. A. J., 7/07/2008, In: Carbohydrate Research. 343, 9, p. 1478-1481 4 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  30. 2007
  31. Published

    Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic

    Baker, J. R., Woolfson, D. N., Muskett, F. W., Stoneman, R. G., Urbaniak, M. D. & Caddick, S., 7/05/2007, In: ChemBioChem. 8, 7, p. 704-717 14 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  32. 2006
  33. Published

    Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness

    Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M. & Ferguson, M. A. J., 15/11/2006, In: Bioorganic and Medicinal Chemistry Letters. 16, 22, p. 5744-5747 4 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  34. Published

    Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant

    Urbaniak, M. D., Turnock, D. C. & Ferguson, M. A. J., 11/2006, In: Eukaryotic Cell. 5, 11, p. 1906-1913 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  35. Published

    Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose

    Alphey, M. S., Burton, A., Urbaniak, M. D., Boons, G.-J., Ferguson, M. A. J. & Hunter, W. N., 1/09/2006, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 62, 9, p. 829-834 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

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