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Research

Professor Mick Urbaniak

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  1. 2010
  2. Published

    Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness

    Durrant, J. D., Urbaniak, M. D., Ferguson, M. A. J. & McCammon, J. A., 8/07/2010, In: Journal of Medicinal Chemistry. 53, 13, p. 5025-5032 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology

    Durrant, J. D., Amaro, R. E., Xie, L., Urbaniak, M. D., Ferguson, M. A. J., Haapalainen, A., Chen, Z., Di Guilmi, A. M., Wunder, F., Bourne, P. E. & McCammon, J. A., 22/01/2010, In: PLoS Computational Biology. 6, 1, 8 p., e1000648.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. 2009
  5. Published

    Chapter 3 The GlcNAc-PI de-N-acetylase. Structure, function, and activity

    Urbaniak, M. D. & Ferguson, M. A. J., 1/12/2009, In: Enzymes. 26, C, p. 49-64 16 p.

    Research output: Contribution to Journal/Magazine › Review article › peer-review

  6. Published

    Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei

    Urbaniak, M. D., 08/2009, In: Molecular and Biochemical Parasitology. 166, 2, p. 183-185 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. 2008
  8. Published

    Probing enzymes late in the trypanosomal glycosylphosphatidylinositol biosynthetic pathway with synthetic glycosylphosphatidylinositol analogues

    Urbaniak, M. D., Yashunsky, D. V., Crossman, A., Nikolaev, A. V. & Ferguson, M. A. J., 17/10/2008, In: ACS Chemical Biology. 3, 10, p. 625-634 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues

    Urbaniak, M. D., Crossman, A. & Ferguson, M. A. J., 08/2008, In: Chemical Biology and Drug Design. 72, 2, p. 127-132 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

    Crossman, A. T., Urbaniak, M. D. & Ferguson, M. A. J., 7/07/2008, In: Carbohydrate Research. 343, 9, p. 1478-1481 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. 2007
  12. Published

    Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic

    Baker, J. R., Woolfson, D. N., Muskett, F. W., Stoneman, R. G., Urbaniak, M. D. & Caddick, S., 7/05/2007, In: ChemBioChem. 8, 7, p. 704-717 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. 2006
  14. Published

    Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness

    Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M. & Ferguson, M. A. J., 15/11/2006, In: Bioorganic and Medicinal Chemistry Letters. 16, 22, p. 5744-5747 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant

    Urbaniak, M. D., Turnock, D. C. & Ferguson, M. A. J., 11/2006, In: Eukaryotic Cell. 5, 11, p. 1906-1913 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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