Home > Research > Researchers > Dr Morgan Gadd > Publications

Research

Dr Morgan Gadd

Formerly at Lancaster University

1 - 10 out of 14Page size: 10
RSS feed of this list
Sort by: Title
  1. Published

    Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.

    Galdeano, C., Gadd, M. S., Soares, P., Scaffidi, S., van Molle, I., Birced, I., Hewitt, S., Dias, D. M. & Ciulli, A., 23/10/2014, In: Journal of Medicinal Chemistry. 57, 20, p. 8657-8663 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    Structural basis of PROTAC cooperative recognition for selective protein degradation

    Gadd, M. S., Testa, A., Lucas, X., Chan, K-H., Chen, W., Lamont, D. J., Zengerle, M. & Ciulli, A., 31/05/2017, In: Nature Chemical Biology. 13, 5, p. 514-521 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.

    Gadd, M. S., Bhati, M., Jeffries, C. M., Langley, D. B., Trewhella, J., Guss, J. M. & Matthews, J. M., 16/12/2011, In: Journal of Biological Chemistry. 286, 50, p. 42971-42980 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.

    Bhati, M., Lee, C., Gadd, M. S., Jeffries, C. M., Kwan, A. H., Whitten, A. E., Trewhella, J., Mackay, J. P. & Matthews, J. M., 25/07/2012, In: PLoS ONE. 7, 7, 9 p., e40719.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases.

    Gadd, M. S., Bulatov, E. & Ciulli, A., 29/06/2015, In: PLoS ONE. 10, 6, 14 p., e0131218.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases

    Aublette, M. C., Harrison, T. A., Thorpe, E. J. & Gadd, M. S., 15/05/2022, In: Bioorganic & medicinal chemistry letters. 64, 8 p., 128636.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

    Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. & Ciulli, A., 4/11/2016, In: Nature Communications. 7, 12 p., 13312.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

    Soares, P., Gadd, M. S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K. D. & Ciulli, A., 25/01/2018, In: Journal of Medicinal Chemistry. 61, 2, p. 599-618 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Crystallization and diffraction of an Lhx4–Isl2 complex.

    Gadd, M. S., Langley, D. B., Guss, J. M. & Matthews, J. M., 31/01/2009, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 65, 2, p. 151-153 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Crystallization and diffraction of an Isl1-Ldb1 complex.

    Gadd, M. S., Jacques, D. A., Guss, J. M. & Matthews, J. M., 1/11/2012, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 68, 11, p. 1398-1401 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

Previous 1 2 Next

Back to top