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Research

Dr Morgan Gadd

Formerly at Lancaster University

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  1. Published

    Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases

    Aublette, M. C., Harrison, T. A., Thorpe, E. J. & Gadd, M. S., 15/05/2022, In: Bioorganic & medicinal chemistry letters. 64, 8 p., 128636.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.

    Bhati, M., Lee, C., Gadd, M. S., Jeffries, C. M., Kwan, A. H., Whitten, A. E., Trewhella, J., Mackay, J. P. & Matthews, J. M., 25/07/2012, In: PLoS ONE. 7, 7, 9 p., e40719.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

    Cardote, T. A. F., Gadd, M. S. & Ciulli, A., 6/06/2017, In: Structure. 25, 6, p. 901-911.e3 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

    Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. & Ciulli, A., 4/11/2016, In: Nature Communications. 7, 12 p., 13312.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes

    Fung, H. K. H., Gadd, M. S., Drury, T. A., Cheung, S., Guss, J. M., Coleman, N. V. & Matthews, J. M., 08/2015, In: Molecular Microbiology. 97, 3, p. 439-453 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Structural basis of PROTAC cooperative recognition for selective protein degradation

    Gadd, M. S., Testa, A., Lucas, X., Chan, K-H., Chen, W., Lamont, D. J., Zengerle, M. & Ciulli, A., 31/05/2017, In: Nature Chemical Biology. 13, 5, p. 514-521 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases.

    Gadd, M. S., Bulatov, E. & Ciulli, A., 29/06/2015, In: PLoS ONE. 10, 6, 14 p., e0131218.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.

    Gadd, M. S., Jacques, D. A., Nisevic, I., Craig, V. J., Kwan, A. H., Guss, J. M. & Matthews, J. M., 26/07/2013, In: Journal of Biological Chemistry. 228, p. 21924-21935 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Crystallization and diffraction of an Isl1-Ldb1 complex.

    Gadd, M. S., Jacques, D. A., Guss, J. M. & Matthews, J. M., 1/11/2012, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 68, 11, p. 1398-1401 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.

    Gadd, M. S., Bhati, M., Jeffries, C. M., Langley, D. B., Trewhella, J., Guss, J. M. & Matthews, J. M., 16/12/2011, In: Journal of Biological Chemistry. 286, 50, p. 42971-42980 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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