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Research

Dr Morgan Gadd

Formerly at Lancaster University

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  1. 2017
  2. Published

    Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

    Cardote, T. A. F., Gadd, M. S. & Ciulli, A., 6/06/2017, In: Structure. 25, 6, p. 901-911.e3 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. 2018
  4. Published

    Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

    Soares, P., Gadd, M. S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K. D. & Ciulli, A., 25/01/2018, In: Journal of Medicinal Chemistry. 61, 2, p. 599-618 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

    Testa, A., Lucas, X., Castro, G. V., Chan, K-H., Wright, J. E., Runcie, A. C., Gadd, M. S., Harrison, W. T. A., Ko, E-J., Fletcher, D. & Ciulli, A., 25/07/2018, In: Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. 2022
  7. Published

    Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases

    Aublette, M. C., Harrison, T. A., Thorpe, E. J. & Gadd, M. S., 15/05/2022, In: Bioorganic & medicinal chemistry letters. 64, 8 p., 128636.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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