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Professor Thomas Jaki

Formerly at Lancaster University

  1. 2024
  2. Published

    A Comparison of Model-Free Phase I Dose Escalation Designs for Dual-Agent Combination Therapies

    Barnett, H., George, M., Skanji, D., Saint-Hilary, G., Jaki, T. & Mozgunov, P., 12/03/2024, In: Statistical Methods in Medical Research. 33, 2, p. 203-226

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  3. 2023
  4. Published

    Using biomarkers to allocate patients in a response-adaptive clinical trial

    Jackson, H., Bowen, S. & Jaki, T., 2/12/2023, In: Communications in Statistics: Simulation and Computation. 52, 12, p. 5946-5965 20 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  5. Published

    Medicines and Healthcare products Regulatory Agency’s “Consultation on proposals for legislative changes for clinical trials”: a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing

    Law, M., Couturier, D-L., Choodari-Oskooei, B., Crout, P., Gamble, C., Jacko, P., Pallmann, P., Pilling, M., Robertson, DS., Robling, M., Sydes, MR., Villar, SS., Wason, J., Wheeler, G., Williamson, S. F., Yap, C. & Jaki, T., 5/10/2023, In: Trials. 24, 1

    Research output: Contribution to Journal/MagazineLetterpeer-review

  6. E-pub ahead of print

    A comparison of Bayesian information borrowing methods in basket trials and a novel proposal of modified exchangeability‐nonexchangeability method

    Daniells, L., Mozgunov, P., Bedding, A. & Jaki, T., 23/08/2023, (E-pub ahead of print) In: Statistics in Medicine.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  7. Published

    A Bayesian multi‐arm multi‐stage clinical trial design incorporating information about treatment ordering

    Serra, A., Mozgunov, P. & Jaki, T., 20/07/2023, In: Statistics in Medicine. 42, 16, p. 2841-2854 14 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  8. Published

    Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study

    Solovyeva, O., Dimairo, M., Weir, C. J., Hee, S. W., Espinasse, A., Ursino, M., Patel, D., Kightley, A., Hughes, S., Jaki, T., Mander, A., Evans, T. R. J., Lee, S., Hopewell, S., Rantell, K. R., Chan, A-W., Bedding, A., Stephens, R., Richards, D., Roberts, L., & 3 othersKirkpatrick, J., de Bono, J. & Yap, C., 5/07/2023, In: BMC Medicine. 21, 1, 246.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  9. Published

    An alternative to traditional sample size determination for small patient populations

    Jackson, H. & Jaki, T., 3/07/2023, In: Statistics in Biopharmaceutical Research. 15, 3, p. 596-607 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  10. Published

    Backfilling cohorts in phase I dose-escalation studies

    Barnett, H., Boix, O., Kontos, D. & Jaki, T., 30/06/2023, In: Clinical Trials. 20, 3, p. 261-268 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  11. Published

    Bayesian sample size determination using commensurate priors to leverage pre‐experimental data

    Zheng, H., Jaki, T. & Wason, J. M. S., 30/06/2023, In: Biometrics. 79, 2, p. 669-683 15 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  12. Published

    Updating the probability of study success for combination therapies using related combination study data

    Graham, E., Harbron, C. & Jaki, T., 30/04/2023, In: Statistical Methods in Medical Research. 32, 4, p. 712-731 20 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  13. Published

    A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule

    Barnett, H. Y., Villar, S. S., Geys, H. & Jaki, T., 31/03/2023, In: Biometrics. 79, 1, p. 86-97 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  14. Published

    Point estimation for adaptive trial designs I: A methodological review

    Robertson, D. S., Choodari‐Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. & Jaki, T., 30/01/2023, In: Statistics in Medicine. 42, 2, p. 122-145 24 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  15. 2022
  16. Published

    Dose finding studies for therapies with late‐onset toxicities: A comparison study of designs

    Barnett, H., Boix, O., Kontos, D. & Jaki, T., 30/12/2022, In: Statistics in Medicine. 41, 30, p. 5767-5788 22 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  17. Published

    Practical implementation of the partial ordering continual reassessment method in a Phase I combination‐schedule dose‐finding trial

    Mozgunov, P., Jaki, T., Gounaris, I., Goddemeier, T., Victor, A. & Grinberg, M., 30/12/2022, In: Stat. Med.. 41, 30, p. 5789-5809 21 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  18. Published

    Generalisations of a Bayesian decision-theoretic randomisation procedure and the impact of delayed responses

    Williamson, S. F., Jacko, P. & Jaki, T., 31/10/2022, In: Computational Statistics and Data Analysis. 174, 26 p., 107407.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  19. Published

    Practical guidance for planning resources required to support publicly-funded adaptive clinical trials

    Wason, J. M. S., Dimairo, M., Biggs, K., Bowden, S., Brown, J., Flight, L., Hall, J., Jaki, T., Lowe, R., Pallmann, P., Pilling, M. A., Snowdon, C., Sydes, M. R., Villar, S. S., Weir, C. J., Wilson, N., Yap, C., Hancock, H. & Maier, R., 10/08/2022, In: BMC Medicine. 20, 1, 12 p., 254.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  20. Published

    A Benchmark for Dose Finding Studies with Unknown Ordering

    Mozgunov, P., Paoletti, X. & Jaki, T., 31/07/2022, In: Biostatistics. 23, 3, p. 721-737 17 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  21. Published

    What is the expected benefit of patient-centric clinical development in oncology?

    Serra, A., Mozgunov, P., Jaki, T. & Rigat, F., 31/07/2022, In: Journal of Biopharmaceutical Statistics. 32, 3, p. 414-426 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  22. Published

    An order restricted multi-arm multi-stage clinical trial design

    Serra, A., Mozgunov, P. & Jaki, T., 30/04/2022, In: Statistics in Medicine. 41, 9, p. 1613-1626 14 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  23. Published

    Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity

    Kuhlemeier, A., Jaki, T., Jimenez, E. Y., Kong, A. S., Gill, H., Chang, C., Resnicow, K., Wilson, D. K. & Van Horn, M. L., 30/04/2022, In: Journal of Behavioral Medicine. 45, 2, p. 211-226 16 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  24. Published

    A dose-finding design for dual-agent trials with patient-specific doses for one agent with application to an opiate detoxification trial

    Mozgunov, P., Cro, S., Lingford-Hughes, A., Paterson, L. M. & Jaki, T., 31/03/2022, In: Pharmaceutical Statistics. 21, 2, p. 476-495 20 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  25. Published

    The need for reporting guidelines for early phase dose-finding trials: Dose-Finding CONSORT Extension

    Yap, C., Bedding, A., de Bono, J., Dimairo, M., Espinasse, A., Evans, J., Hopewell, S., Jaki, T., Kightley, A., Lee, S., Liu, R., Mander, A., Solovyeva, O. & Weir, C. J., 31/01/2022, In: Nature Medicine. 28, 1, p. 6-7 2 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  26. Published

    Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic

    Ewings, S., Saunders, G., Jaki, T. & Mozgunov, P., 20/01/2022, In: BMC Medical Research Methodology. 22, 1, 15 p., 25.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  27. 2021
  28. Published

    Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

    Khoo, S. H., Fitzgerald, R., Fletcher, T., Ewings, S., Jaki, T., Lyon, R., Downs, N., Walker, L., Tansley-Hancock, O., Greenhalf, W., Woods, C., Reynolds, H., Marwood, E., Mozgunov, P., Adams, E., Bullock, K., Holman, W., Bula, M. D., Gibney, J. L., Saunders, G., & 18 othersCorkhill, A., Hale, C., Thorne, K., Chiong, J., Condie, S., Pertinez, H., Painter, W., Wrixon, E., Johnson, L., Yeats, S., Mallard, K., Radford, M., Fines, K., Shaw, V., Owen, A., Lalloo, D. G., Jacobs, M. & Griffiths, G., 12/11/2021, In: Journal of Antimicrobial Chemotherapy. 76, 12, p. 3286-3295 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  29. Published

    A permutation test for assessing the presence of individual differences in treatment effects

    Chang, C., Jaki, T., Sadiq, M. S., Kuhlemeier, A., Feaster, D., Cole, N., Lamont, A., Oberski, D., Desai, Y. & Lee Van Horn, M., 1/11/2021, In: Statistical Methods in Medical Research. 30, 11, p. 2369-2381 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

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