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Healthy and pre-eclamptic placental basal plate lining cells: quantitative comparisons based on confocal laser scanning microscopy

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Healthy and pre-eclamptic placental basal plate lining cells: quantitative comparisons based on confocal laser scanning microscopy. / Smith, R K ; Ockleford, C D ; Byrne, S et al.
In: Microscopy Research and Technique, Vol. 64, No. 1, 01.05.2004, p. 54-62.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Smith, RK, Ockleford, CD, Byrne, S, Bosio, P & Sanders, R 2004, 'Healthy and pre-eclamptic placental basal plate lining cells: quantitative comparisons based on confocal laser scanning microscopy', Microscopy Research and Technique, vol. 64, no. 1, pp. 54-62. https://doi.org/10.1002/jemt.20047

APA

Smith, R. K., Ockleford, C. D., Byrne, S., Bosio, P., & Sanders, R. (2004). Healthy and pre-eclamptic placental basal plate lining cells: quantitative comparisons based on confocal laser scanning microscopy. Microscopy Research and Technique, 64(1), 54-62. https://doi.org/10.1002/jemt.20047

Vancouver

Smith RK, Ockleford CD, Byrne S, Bosio P, Sanders R. Healthy and pre-eclamptic placental basal plate lining cells: quantitative comparisons based on confocal laser scanning microscopy. Microscopy Research and Technique. 2004 May 1;64(1):54-62. doi: 10.1002/jemt.20047

Author

Smith, R K ; Ockleford, C D ; Byrne, S et al. / Healthy and pre-eclamptic placental basal plate lining cells : quantitative comparisons based on confocal laser scanning microscopy. In: Microscopy Research and Technique. 2004 ; Vol. 64, No. 1. pp. 54-62.

Bibtex

@article{2174319ce12142499878264e692a79a9,
title = "Healthy and pre-eclamptic placental basal plate lining cells: quantitative comparisons based on confocal laser scanning microscopy",
abstract = "Immunocytochemical confocal laser scanning microscope images of the monolayer of cells lining the intervillus space at the basal plate of term placentae were analysed using stereology. Immunoreactively-distinct regions of this mosaic layer were measured. In basal plate from healthy pregnancies, trophoblast epithelium occupied 18.91% of the surface area and endothelium 60.81%. In pre-eclampsia the equivalent areas were 15.57% and 67.63%. Acellular fibrinoid covers the remaining area and this component decreases in area in pre-eclampsia. The statistically significant increase in the cellular endothelial compartment may be relevant to the hypertensive pathology of pre-eclampsia as endothelial signalling plays a major role in regulation of blood pressure. (C) 2004 Wiley-Liss, Inc.",
keywords = "pre-eclampsia • basal plate • intervillus space • caveolin-1 • endothelial cells • trophoblast invasion • cytokeratin expression • placental development",
author = "Smith, {R K} and Ockleford, {C D} and S Byrne and P Bosio and R Sanders",
note = "RAE_import_type : Journal article RAE_uoa_type : Allied Health Professions and Studies",
year = "2004",
month = may,
day = "1",
doi = "10.1002/jemt.20047",
language = "English",
volume = "64",
pages = "54--62",
journal = "Microscopy Research and Technique",
issn = "1059-910X",
publisher = "Wiley-Liss Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Healthy and pre-eclamptic placental basal plate lining cells

T2 - quantitative comparisons based on confocal laser scanning microscopy

AU - Smith, R K

AU - Ockleford, C D

AU - Byrne, S

AU - Bosio, P

AU - Sanders, R

N1 - RAE_import_type : Journal article RAE_uoa_type : Allied Health Professions and Studies

PY - 2004/5/1

Y1 - 2004/5/1

N2 - Immunocytochemical confocal laser scanning microscope images of the monolayer of cells lining the intervillus space at the basal plate of term placentae were analysed using stereology. Immunoreactively-distinct regions of this mosaic layer were measured. In basal plate from healthy pregnancies, trophoblast epithelium occupied 18.91% of the surface area and endothelium 60.81%. In pre-eclampsia the equivalent areas were 15.57% and 67.63%. Acellular fibrinoid covers the remaining area and this component decreases in area in pre-eclampsia. The statistically significant increase in the cellular endothelial compartment may be relevant to the hypertensive pathology of pre-eclampsia as endothelial signalling plays a major role in regulation of blood pressure. (C) 2004 Wiley-Liss, Inc.

AB - Immunocytochemical confocal laser scanning microscope images of the monolayer of cells lining the intervillus space at the basal plate of term placentae were analysed using stereology. Immunoreactively-distinct regions of this mosaic layer were measured. In basal plate from healthy pregnancies, trophoblast epithelium occupied 18.91% of the surface area and endothelium 60.81%. In pre-eclampsia the equivalent areas were 15.57% and 67.63%. Acellular fibrinoid covers the remaining area and this component decreases in area in pre-eclampsia. The statistically significant increase in the cellular endothelial compartment may be relevant to the hypertensive pathology of pre-eclampsia as endothelial signalling plays a major role in regulation of blood pressure. (C) 2004 Wiley-Liss, Inc.

KW - pre-eclampsia • basal plate • intervillus space • caveolin-1 • endothelial cells • trophoblast invasion • cytokeratin expression • placental development

U2 - 10.1002/jemt.20047

DO - 10.1002/jemt.20047

M3 - Journal article

VL - 64

SP - 54

EP - 62

JO - Microscopy Research and Technique

JF - Microscopy Research and Technique

SN - 1059-910X

IS - 1

ER -