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The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya

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The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya. / Abubakar, Amina; Holding, Penny; Newton, Charles R. J. C. et al.
In: Developmental Medicine and Child Neurology, Vol. 51, No. 12, 12.2009, p. 968-973.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Abubakar, A, Holding, P, Newton, CRJC, van Baar, A & van de Vijver, FJR 2009, 'The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya', Developmental Medicine and Child Neurology, vol. 51, no. 12, pp. 968-973. https://doi.org/10.1111/j.1469-8749.2009.03333.x

APA

Abubakar, A., Holding, P., Newton, C. R. J. C., van Baar, A., & van de Vijver, F. J. R. (2009). The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya. Developmental Medicine and Child Neurology, 51(12), 968-973. https://doi.org/10.1111/j.1469-8749.2009.03333.x

Vancouver

Abubakar A, Holding P, Newton CRJC, van Baar A, van de Vijver FJR. The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya. Developmental Medicine and Child Neurology. 2009 Dec;51(12):968-973. doi: 10.1111/j.1469-8749.2009.03333.x

Author

Abubakar, Amina ; Holding, Penny ; Newton, Charles R. J. C. et al. / The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya. In: Developmental Medicine and Child Neurology. 2009 ; Vol. 51, No. 12. pp. 968-973.

Bibtex

@article{15ab0538bcee4f748acb1c3d30c7f9e8,
title = "The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya",
abstract = "AIM: We aimed to investigate the contribution of disease stage and weight for age to the variability in psychomotor outcome observed among children with human immunodeficiency virus (HIV) infection.METHOD: This cross-sectional study involved 48 Kenyan children (20 females, 28 males) aged 6 to 35 months (mean 19.9mo SD 8.9) exposed prenatally to HIV. Two subgroups of HIV-exposed children were seen: those who were HIV-infected and those who were uninfected. The reference population was composed of 319 children (159 females, 160 males) aged 6-35 months, (mean age = 19 months, SD=8.43) randomly selected from the community. Disease stage varied from stage 1 to stage 3, reflecting progression from primary HIV infection to advanced HIV infection and acquired immune deficiency syndrome. A locally developed and validated measure, the Kilifi Developmental Inventory, was used to assess psychomotor development.RESULT: Using age-corrected psychomotor scores, a significant main effect of HIV status was observed (F((2,38.01))=7.89, p<0.001). Children in the HIV-infected group had lower mean psychomotor scores than the HIV-exposed children and the reference group. In the HIV-infected group, disease stage was a negative predictor and weight for age a positive predictor of psychomotor outcome.INTERPRETATION: Weight for age and disease stage provide viable, easily measurable benchmarks to specify when frequent developmental monitoring and psychomotor rehabilitation are required. Nutritional intervention and other measures aimed at slowing disease progression may delay the onset and severity of psychomotor impairment in the paediatric HIV population in Africa.",
keywords = "Acquired Immunodeficiency Syndrome, Body Weight, Case-Control Studies, Child Development, Child, Preschool, Cross-Sectional Studies, Developmental Disabilities, Female, HIV Infections, Humans, Infant, Kenya, Male, Nutritional Status, Poverty, Psychomotor Disorders, Psychomotor Performance, Reference Values, Severity of Illness Index",
author = "Amina Abubakar and Penny Holding and Newton, {Charles R. J. C.} and {van Baar}, Anneloes and {van de Vijver}, {Fons J. R.}",
year = "2009",
month = dec,
doi = "10.1111/j.1469-8749.2009.03333.x",
language = "English",
volume = "51",
pages = "968--973",
journal = "Developmental Medicine and Child Neurology",
issn = "0012-1622",
publisher = "Wiley-Blackwell",
number = "12",

}

RIS

TY - JOUR

T1 - The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya

AU - Abubakar, Amina

AU - Holding, Penny

AU - Newton, Charles R. J. C.

AU - van Baar, Anneloes

AU - van de Vijver, Fons J. R.

PY - 2009/12

Y1 - 2009/12

N2 - AIM: We aimed to investigate the contribution of disease stage and weight for age to the variability in psychomotor outcome observed among children with human immunodeficiency virus (HIV) infection.METHOD: This cross-sectional study involved 48 Kenyan children (20 females, 28 males) aged 6 to 35 months (mean 19.9mo SD 8.9) exposed prenatally to HIV. Two subgroups of HIV-exposed children were seen: those who were HIV-infected and those who were uninfected. The reference population was composed of 319 children (159 females, 160 males) aged 6-35 months, (mean age = 19 months, SD=8.43) randomly selected from the community. Disease stage varied from stage 1 to stage 3, reflecting progression from primary HIV infection to advanced HIV infection and acquired immune deficiency syndrome. A locally developed and validated measure, the Kilifi Developmental Inventory, was used to assess psychomotor development.RESULT: Using age-corrected psychomotor scores, a significant main effect of HIV status was observed (F((2,38.01))=7.89, p<0.001). Children in the HIV-infected group had lower mean psychomotor scores than the HIV-exposed children and the reference group. In the HIV-infected group, disease stage was a negative predictor and weight for age a positive predictor of psychomotor outcome.INTERPRETATION: Weight for age and disease stage provide viable, easily measurable benchmarks to specify when frequent developmental monitoring and psychomotor rehabilitation are required. Nutritional intervention and other measures aimed at slowing disease progression may delay the onset and severity of psychomotor impairment in the paediatric HIV population in Africa.

AB - AIM: We aimed to investigate the contribution of disease stage and weight for age to the variability in psychomotor outcome observed among children with human immunodeficiency virus (HIV) infection.METHOD: This cross-sectional study involved 48 Kenyan children (20 females, 28 males) aged 6 to 35 months (mean 19.9mo SD 8.9) exposed prenatally to HIV. Two subgroups of HIV-exposed children were seen: those who were HIV-infected and those who were uninfected. The reference population was composed of 319 children (159 females, 160 males) aged 6-35 months, (mean age = 19 months, SD=8.43) randomly selected from the community. Disease stage varied from stage 1 to stage 3, reflecting progression from primary HIV infection to advanced HIV infection and acquired immune deficiency syndrome. A locally developed and validated measure, the Kilifi Developmental Inventory, was used to assess psychomotor development.RESULT: Using age-corrected psychomotor scores, a significant main effect of HIV status was observed (F((2,38.01))=7.89, p<0.001). Children in the HIV-infected group had lower mean psychomotor scores than the HIV-exposed children and the reference group. In the HIV-infected group, disease stage was a negative predictor and weight for age a positive predictor of psychomotor outcome.INTERPRETATION: Weight for age and disease stage provide viable, easily measurable benchmarks to specify when frequent developmental monitoring and psychomotor rehabilitation are required. Nutritional intervention and other measures aimed at slowing disease progression may delay the onset and severity of psychomotor impairment in the paediatric HIV population in Africa.

KW - Acquired Immunodeficiency Syndrome

KW - Body Weight

KW - Case-Control Studies

KW - Child Development

KW - Child, Preschool

KW - Cross-Sectional Studies

KW - Developmental Disabilities

KW - Female

KW - HIV Infections

KW - Humans

KW - Infant

KW - Kenya

KW - Male

KW - Nutritional Status

KW - Poverty

KW - Psychomotor Disorders

KW - Psychomotor Performance

KW - Reference Values

KW - Severity of Illness Index

U2 - 10.1111/j.1469-8749.2009.03333.x

DO - 10.1111/j.1469-8749.2009.03333.x

M3 - Journal article

C2 - 19486107

VL - 51

SP - 968

EP - 973

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

SN - 0012-1622

IS - 12

ER -