Bringing Innovative Methods for Early Phase Precision Medicine Trials Into Practice (BINOP)

Project: Research

Status	Finished
Effective start/end date	1/07/20 → 31/03/21

Funding

National Institute for Health Research: £678,420.00

Mozgunov, Pavel (Principal Investigator)

Research outputs

An information-theoretic approach for selecting arms in clinical trials
Research output: Contribution to Journal/Magazine › Journal article › peer-review
A Benchmark for Dose Finding Studies with Unknown Ordering
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments?: A Simulation Study
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Response adaptive designs for Phase II trials with binary endpoint based on context-dependent information measures
Research output: Contribution to Journal/Magazine › Journal article › peer-review
A dose-finding design for dual-agent trials with patient-specific doses for one agent with application to an opiate detoxification trial
Research output: Contribution to Journal/Magazine › Journal article › peer-review
An order restricted multi-arm multi-stage clinical trial design
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic
Research output: Contribution to Journal/Magazine › Journal article › peer-review
A comparison of various aggregation functions in multi-criteria decision analysis for drug benefit–risk assessment
Research output: Contribution to Journal/Magazine › Journal article › peer-review
What is the expected benefit of patient-centric clinical development in oncology?
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Practical implementation of the partial ordering continual reassessment method in a Phase I combination‐schedule dose‐finding trial
Research output: Contribution to Journal/Magazine › Journal article › peer-review

Research

Bringing Innovative Methods for Early Phase Precision Medicine Trials Into Practice (BINOP)

Funding

Research outputs

An information-theoretic approach for selecting arms in clinical trials

A Benchmark for Dose Finding Studies with Unknown Ordering

Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs

Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments?: A Simulation Study

Response adaptive designs for Phase II trials with binary endpoint based on context-dependent information measures

A dose-finding design for dual-agent trials with patient-specific doses for one agent with application to an opiate detoxification trial

An order restricted multi-arm multi-stage clinical trial design

Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic

A comparison of various aggregation functions in multi-criteria decision analysis for drug benefit–risk assessment

What is the expected benefit of patient-centric clinical development in oncology?

Practical implementation of the partial ordering continual reassessment method in a Phase I combination‐schedule dose‐finding trial

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