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Current Postgraduate Research Students

Alexandre Benedetto supervises 4 postgraduate research students. If these students have produced research profiles, these are listed below:

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Dr Alexandre Benedetto

Lecturer

Alexandre Benedetto

Furness Building

LA1 4YG

Lancaster

Tel: +44 1524 594999

Research overview

I wish to understand how animals and their microbiome communicate throughout life to maintain homeostasis. To probe such interactions, I study C. elegans and its adult gut microbiota under challenging conditions (infection, neurodegenerative diseases, stress, ageing). Combining genome-wide phenotyping screens, RNAseq and in chip time-lapse imaging, I aim to map the genetic network that governs worm gut-bacteria interactions (BBSRC: BB/S017127/1). In parallel, I also study the regulation of abrupt death in C. elegans in a bid to identify interventions that can halt or delay tissue decay and organismal death (Wellcome Trust: 214076/Z/18/Z). Lastly, I develop and apply microfludics and microfabricated devices for the quantitative study of cancer development and progression in cell and tissue culture models (NWCR).

PhD supervision

I can welcome PhD and MSc by Research students interested in studying: - the spatiotemporal dynamics of gut host-microbiota interactions using a combination of advanced genomic, spectrophotometric and on-chip live-imaging microscopy techniques in the model organism C. elegans. - the dynamics of bacterial biofilm regulation in vivo in the model organism C. elegans. - the neuronal regulation of organismal death in C. elegans using advanced imaging of tissue-specific genetically-encoded calcium and pH reporters. - Autophagy and proteasome regulation in C. elegans - the role of intercellular variability in cancer progression using advanced live microscopy imaging and automated analysis techniques (in collaboration with Dr. Richard Mort). We have a NWCR-funded project for a Msc by Research student starting in October 2019 (see link here: https://www.findaphd.com/phds/project/msc-by-research-project-the-impact-of-temperature-shifts-on-breast-uveal-and-skin-cancer-cell-dynamics/?p110785). Contact and send your CV by email to a.benedetto@lancaster.ac.uk, r.mort@lancaster.ac.uk, or a.fielding@lancaster.ac.uk to know more. Deadline for applications: 12/07/2019.

Current Teaching

BIOL114 - Biotechnology

BIOL364 - Biology of Ageing (Module organiser)

BIOL383 - Innovations in Biosciences (Module organiser)

BIOL461 - Fundamental Research Skills

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