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Current Postgraduate Research Students

Alexandre Benedetto supervises 1 postgraduate research students. If these students have produced research profiles, these are listed below:

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Dr Alexandre Benedetto

Lecturer

Alexandre Benedetto

Furness Building

LA1 4YG

Lancaster

Tel: +44 1524 594999

Research overview

I wish to understand how animals and their microbiome communicate throughout life to maintain homeostasis. To probe such interactions, I study C. elegans and its adult gut microbiota under challenging conditions (infection, neurodegenerative diseases, stress, ageing). Combining genome-wide phenotyping screens, RNAseq and in chip time-lapse imaging, I aim to map the genetic network that governs worm gut-bacteria interactions. In parallel, I also study the regulation of abrupt death in C. elegans in a bid to identify interventions that can halt or delay tissue decay and organismal death. Lastly, I develop and apply microfludics and microfabricated devices for the quantitative study of cancer development and progression in cell and tissue culture models.

PhD supervision

I can welcome PhD and MSc research students (No funded positions currently available) interested in studying: - the spatiotemporal dynamics of gut host-microbiota interactions using a combination of advanced genomic, spectrophotometric and on-chip live-imaging microscopy techniques in the model organism C. elegans. - the dynamics of bacterial biofilm regulation in vivo in the model organism C. elegans. - the neuronal regulation of organismal death in C. elegans using advanced imaging of tissue-specific genetically-encoded calcium and pH reporters. - Autophagy and proteasome regulation in C. elegans - the role of intercellular variability in cancer progression using advanced live microscopy imaging and automated analysis techniques (in collaboration with Dr. Richard Mort).

Current Teaching

BIOL114 - Biotechnology

BIOL364 - Biology of Ageing

BIOL383 - Innovations in Biosciences (co-organisor)

BIOL461 - Fundamental Research Skills

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