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Professor Christian Holscher

Formerly at Lancaster University

  1. Published

    An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

    Bomfim, T. R., Forny-Germano, L., Sathler, L. B., Brito-Moreira, J., Houzel, J-C., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., Holscher, C., Arnold, S. E., Talbot, K., Klein, W. L., Munoz, D. P., Ferreira, S. T. & De Felice, F. G., 2/04/2012, In : Journal of Clinical Investigation. 122, 4, p. 1339-1353 15 p.

    Research output: Contribution to journalJournal article

  2. Published

    Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats

    Cai, H-Y., Hölscher, C., Yue, X-H., Zhang, S-X., Wang, X-H., Qiao, F., Yang, W. & Qi, J-S., 26/09/2014, In : Neuroscience. 277, p. 6-13 8 p.

    Research output: Contribution to journalJournal article

  3. Published

    Lixisenatide attenuates the detrimental effects of amyloid β protein on spatial working memory and hippocampal neurons in rats

    Cai, H-Y., Wang, Z-J., Holscher, C., Yuan, L., Zhang, J., Sun, P., Li, J., Yang, W., Wu, M-N. & Qi, J-S., 1/02/2017, In : Behavioural Brain Research. 318, p. 28-35 8 p.

    Research output: Contribution to journalJournal article

  4. Published

    DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease

    Cao, Y., Hölscher, C., Hu, M-M., Wang, T., Zhao, F., Bai, Y., Zhang, J., Wu, M-N. & Qi, J-S., 15/05/2018, In : European Journal of Pharmacology. 827, p. 215-226 12 p.

    Research output: Contribution to journalJournal article

  5. Published

    Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

    Chen, Y., Zhang, Y., Li, L. & Holscher, C., 5/12/2015, In : European Journal of Pharmacology. 768, p. 21-27 7 p.

    Research output: Contribution to journalJournal article

  6. Published

    Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats

    Du, Y., Du, L., Cao, J., Holscher, C., Feng, Y., Su, H., Wang, Y. & Yun, K-M., 15/01/2017, In : Behavioural Brain Research. 317, p. 367-373 7 p.

    Research output: Contribution to journalJournal article

  7. Published

    The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease

    Duffy, A. M. & Hölscher, C., 3/01/2013, In : Neuroscience. 228, p. 294-300 7 p.

    Research output: Contribution to journalJournal article

  8. Published

    Neuroprotective effects of D-Ala2GIP on Alzheimer’s disease biomarkers in an APP/PS1 mouse model

    Faivre, E. & Holscher, C., 19/04/2013, In : Alzheimer's Research and Therapy. 5, p. 20-29 10 p., 20.

    Research output: Contribution to journalJournal article

  9. Published

    D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer’s disease mouse model

    Faivre, E. & Holscher, C., 8/04/2013, In : Journal of Alzheimer's Disease. 35, 2, p. 267-283 17 p.

    Research output: Contribution to journalJournal article

  10. Published

    Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

    Faivre, E., Hamilton, A. & Hölscher, C., 15/01/2012, In : European Journal of Pharmacology. 674, 2-3, p. 294-306 13 p.

    Research output: Contribution to journalJournal article

  11. Published

    Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

    Faivre, E., Gault, V. A., Thorens, B. & Hölscher, C., 1/04/2011, In : Journal of Neurophysiology. 105, 4, p. 1574-1580 7 p.

    Research output: Contribution to journalJournal article

  12. Published

    The effect of mGlu8 deficiency in animal models of psychiatric diseases

    Fendt, M., Bürki, H., Imobersteg, S., van der Putten, H., McAllister, K., Leslie, J. C., Shaw, D. & Hölscher, C., 02/2010, In : Genes, Brain and Behavior. 9, 1, p. 33-44 12 p.

    Research output: Contribution to journalJournal article

  13. Published

    Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease

    Feng, P., Zhang, X., Li, D., Ji, C., Yuan, Z., Wang, R., Xue, G., Li, G. & Hölscher, C., 1/05/2018, In : Neuropharmacology. 133, p. 385-394 10 p.

    Research output: Contribution to journalJournal article

  14. Published

    Intranasal insulin as a treatment for Alzheimer’s Disease: a review of basic research and clinical evidence

    Freiherr, J., Hallschmid, M., Frey, W., Brünner, Y., Chapman, C., Holscher, C., Craft, S., De Felice, F. & Benedict, C., 07/2013, In : CNS Drugs. 27, 7, p. 505-514 10 p.

    Research output: Contribution to journalJournal article

  15. Published

    New animal models of Alzheimer's disease that display insulin desensitization in the brain

    Gao, C., Liu, Y., Li, L. & Hölscher, C., 12/2013, In : Reviews in the Neurosciences. 24, 6, p. 607-615 9 p.

    Research output: Contribution to journalJournal article

  16. Published

    GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

    Gao, C., Hölscher, C., Liu, Y. & Li, L., 02/2012, In : Reviews in the Neurosciences. 23, 1, p. 1-11 11 p.

    Research output: Contribution to journalJournal article

  17. Published

    Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

    Gault, V. A., Porter, W. D., Flatt, P. R. & Holscher, C., 08/2010, In : International Journal of Obesity. 34, p. 1341-1344 4 p.

    Research output: Contribution to journalJournal article

  18. Published

    Beneficial actions of glucagon-like peptide 1 (GLP-1) on hippocampal synaptic plasticity, gene expression, oxidative stress and inflammation in mice with diet-induced obesity and insulin resistance

    Gault, V., Lennox, R., Porter, D., Holscher, C. & Flatt, P., 03/2013, In : Diabetic Medicine. 30, Supplement 1, p. 4 1 p., A9 (P99).

    Research output: Contribution to journalMeeting abstract

  19. Published

    GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes

    Gault, V. A. & Hölscher, C., 02/2018, In : Peptides. 100, p. 101-107 7 p.

    Research output: Contribution to journalJournal article

  20. Published

    Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

    Gengler, S., McClean, P. L., McCurtin, R., Gault, V. A. & Holscher, C., 02/2012, In : Neurobiology of Aging. 33, 2, p. 265-276 12 p.

    Research output: Contribution to journalJournal article

  21. Published

    Synaptic plasticity in the hippocampus of an APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice

    Gengler, S., Hamilton, A. & Holscher, C., 22/03/2010, In : PLoS ONE. 5, 3, 10 p., e9764.

    Research output: Contribution to journalJournal article

  22. Published

    H-1 NMR metabolomics investigation of an Alzheimer's disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma

    Graham, S. F., Holscher, C., McClean, P., Elliot, C. T. & Green, B. D., 10/2013, In : Metabolomics. 9, 5, p. 974-983 10 p.

    Research output: Contribution to journalJournal article

  23. Published

    Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Roberts, D., Hölscher, C., Elliott, C. T. & Green, B. D., 5/02/2013, In : Analytical Chemistry. 85, 3, p. 1803-1811 9 p.

    Research output: Contribution to journalJournal article

  24. Published

    Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies

    Graham, S. F., Nasaruddin, M. B., Carey, M., Holscher, C., McGuinness, B., Kehoe, P. G., Love, S., Passmore, P., Elliott, C. T., Meharg, A. A. & Green, B. D., 2014, In : Journal of Alzheimer's Disease. 42, 4, p. 1407-1413 7 p.

    Research output: Contribution to journalJournal article

  25. Published

    Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue

    Graham, S. F., Holscher, C. & Green, B. D., 08/2014, In : Metabolomics. 10, 4, p. 744-753 10 p.

    Research output: Contribution to journalJournal article

  26. Published

    Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's Disease and dementia with Lewy bodies

    Graham, S. F., Nasarauddin, M. B., Carey, M., McGuinness, B., Holscher, C., Kehoe, P. G., Love, S., Passmore, A. P., Elliott, C. T., Meharg, A. & Green, B. D., 2015, In : Journal of Alzheimer's Disease. 44, 3, p. 851-857 7 p.

    Research output: Contribution to journalJournal article

  27. Published

    Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Elliott, C. T., Holscher, C., Johnston, J., McGuinness, B., Kehoe, P. G., Passmore, A. P. & Green, B. D., 24/03/2015, In : PLoS ONE. 10, 3, 16 p., e0119452.

    Research output: Contribution to journalJournal article

  28. Published

    The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease

    Hamilton, A. & Holscher, C., 17/04/2012, In : Brain Research. 1449, p. 83-93 11 p.

    Research output: Contribution to journalJournal article

  29. Published

    Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

    Hamilton, A., Patterson, S., Porter, D., Gault, V. A. & Hölscher, C., 04/2011, In : Journal of Neuroscience Research. 89, 4, p. 481-489 9 p.

    Research output: Contribution to journalJournal article

  30. Published

    Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

    Hamilton, A. & Hölscher, C., 26/08/2009, In : NeuroReport. 20, 13, p. 1161-1166 6 p.

    Research output: Contribution to journalJournal article

  31. Published

    Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

    Han, W-N., Hölscher, C., Yuan, L., Yang, W., Wang, X-H., Wu, M-N. & Qi, J-S., 02/2013, In : Neurobiology of Aging. 34, 2, p. 576-588 13 p.

    Research output: Contribution to journalJournal article

  32. Published

    A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat

    Han, L., Holscher, C., Xue, G., Li, G. & Li, D., 6/01/2016, In : NeuroReport. 27, 1, p. 23-32 10 p.

    Research output: Contribution to journalJournal article

  33. Published

    抗糖尿病新药(D-Ser2)Oxm 拮抗淀粉样β 蛋白细胞毒性的神经保护 效应观察

    Han, Y-F., Hölscher, C., Wang, Z-J., Zhang, J., Yuan, L., Tong, J-Q., Wang, D-D., Wu, M-N. & Qi, J-S., 25/06/2016, In : Acta Physiologica Sinica. 68, 3, p. 265-275 11 p.

    Research output: Contribution to journalJournal article

  34. Published

    Potential roles of glucagon-like peptide-1 (GLP-1) in neuroprotection

    Holscher, C., 10/2012, In : CNS Drugs. 26, 10, p. 871-882 12 p.

    Research output: Contribution to journalJournal article

  35. Published

    Diabetes as a risk factor for Alzheimer’s disease: insulin signalling impairment in the brain as an alternative model of Alzheimer’s disease

    Holscher, C., 08/2011, In : Biochemical Society Transactions. 39, 4, p. 891-897 7 p.

    Research output: Contribution to journalJournal article

  36. Published

    Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

    Holscher, C., 1/04/2014, In : Journal of Endocrinology. 221, p. T31-T41 11 p.

    Research output: Contribution to journalJournal article

  37. Published

    Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects

    Holscher, C., 06/2014, In : Regulatory Peptides. 192-193, p. 55-56 2 p.

    Research output: Contribution to journalEditorial

  38. Published

    Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

    Hölscher, C., 1/04/2014, In : Biochemical Society Transactions. 42, 2, p. 593-599 7 p.

    Research output: Contribution to journalJournal article

  39. Published

    The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

    Hölscher, C., 02/2014, In : Alzheimer's and Dementia. 10, 1 Supplement, p. S47-54 8 p.

    Research output: Contribution to journalJournal article

  40. Published

    First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

    Hölscher, C., 02/2014, In : Alzheimer's and Dementia. 10, 1 Supplement, p. S33-37 5 p.

    Research output: Contribution to journalJournal article

  41. Published

    The role of GLP-1 in neuronal activity and neurodegeneration

    Hölscher, C., 2010, In : Vitamins and Hormones. 84, p. 331-354 24 p.

    Research output: Contribution to journalJournal article

  42. Published

    Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease

    Hölscher, C., 06/2010, In : Recent Patents on CNS Drug Discovery. 5, 2, p. 109-117 9 p.

    Research output: Contribution to journalJournal article

  43. Published

    Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide analogues as novel treatments for Alzheimer's and Parkinson's disease

    Hölscher, C., 1/09/2016, In : Cardiovascular Endocrinology . 5, 3, p. 93-98 6 p.

    Research output: Contribution to journalJournal article

  44. Published

    Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

    Hölscher, C., 1/07/2018, In : Neuropharmacology. 136, Part B, p. 251-259 9 p.

    Research output: Contribution to journalJournal article

  45. Published

    Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

    Hölscher, C., De Felice, F. G., Greig, N. & Ferreira, S. T., 1/07/2018, In : Neuropharmacology. 136, Part B, p. 159 1 p.

    Research output: Contribution to journalEditorial

  46. Published

    Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology

    Holubová, M., Hrubá, L., Popelová, A., Bencze, M., Pražienková, V., Gengler, S., Kratochvílová, H., Haluzík, M., Železná, B., Kuneš, J., Hölscher, C. & Maletínská, L., 01/2019, In : Neuropharmacology. 144, p. 377-387 11 p.

    Research output: Contribution to journalJournal article

  47. Published

    Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

    Hunter, K. & Holscher, C., 2012, In : BMC Neuroscience. 13, p. 33-38 6 p.

    Research output: Contribution to journalJournal article

  48. Published

    Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study

    Jalewa, J., Joshi, A., McGinnity, T. M., Prasad, G., Wong-Lin, K. & Hölscher, C., 6/02/2014, In : PLoS ONE. 9, 2, 16 p., e88003.

    Research output: Contribution to journalJournal article

  49. Published

    Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

    Jalewa, J., Sharma, M. K. & Holscher, C., 10/2016, In : Journal of Neurochemistry. 139, 1, p. 55-67 13 p.

    Research output: Contribution to journalJournal article

  50. Published

    A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease

    Jalewa, J., Sharma, M. K., Gengler, S. & Hölscher, C., 1/05/2017, In : Neuropharmacology. 117, p. 238-248 11 p.

    Research output: Contribution to journalJournal article

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