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Home > Research > Researchers > Edward Parkin
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Current Postgraduate Research Students

Edward Parkin supervises 2 postgraduate research students. Some of the students have produced research profiles, these are listed below:

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Dr Edward Parkin

Lecturer

Edward Parkin

Furness Building

Lancaster University

Bailrigg

Lancaster LA1 4YG

United Kingdom

Tel: +44 1524 592246

Location:

Research overview

Dr Edward Parkin is interested in the role played by the proteolysis of cell surface proteins in prostate and colorectal cancers and in the neurodegenerative condition, Alzheimer's disease (AD).

 

 

Research Interests

The amyloid precursor protein (APP) and Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative condition caused by accumulation within the brain of neurotoxic amyloid beta (Aß)-peptides. These short peptides are derived from the larger amyloid precursor protein (APP) through sequential cleavage by two enzymes known as β- and γ-secretases. Alternatively, APP can be shed from the cell surface through the action of an α-secretase which cleaves within the Aß region of the molecule thereby precluding the formation of intact Aß-peptides. We are particularly interested in the role played by a group of enzymes called 'ADAMs' in α-secretase cleavage of APP. Up-regulation of these enzyme activities may be beneficial in AD. We also conduct a considerable amount of work on the role of copper and APP binding of this metal in AD.

APP and cancer

Although APP has received most attention for its role in AD, more recent studies, including our own, have shown that the protein has a role to play in various cancers. We have shown that copper binding by this protein enables prostate cancer cells to grow effectively despite the high concentrations of this metal found in tumours. We have also shown that APP induces a change in prostate cancer cells known as epithelial-to-mesenchymal transition (EMT) which facilitates spread of the cancer throughout the body.

Notch signalling in cancer

Notch signalling is a mechanism that cells use to communicate with each other, essentially telling each other how to grow and divide. When this signalling pathway breaks down the cells grow uncontrollably into tumours. We are very interested in the role played by Notch signalling in prostate and colorectal cancers.

Profile

Education

  • 1995 Ph.D. (Plant biochemistry), University of Central Lancashire, Preston
  • 1990 B.Sc.(Hons) Biochemistry, Lancaster University

Academic Posts

  • 1995-1998 Research Fellow, University of Leeds
  • 1998-2001 Research Fellow, University of Leeds
  • 2001-2004 Research Fellow, University of Leeds
  • 2004-2006 Senior Experimental Officer, University of Leeds
  • 2007-present Lecturer in Biochemistry, Lancaster University

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