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Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering

Research output: Contribution to journalJournal article

Published
  • John George Hardy
  • Jose Guillermo Torres-Rendon
  • Aldo Leal-Egana
  • Andreas Walther
  • Helmut Schlaad
  • Helmut Cölfen
  • Thomas Rainer Scheibel
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Article number560
<mark>Journal publication date</mark>11/07/2016
<mark>Journal</mark>Materials
Issue number7
Volume9
Number of pages13
StatePublished
Original languageEnglish

Abstract

Materials based on biodegradable polyesters such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT) have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein is reported the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.