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  • materials-123114-final-pure

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  • materials-09-00560-FINAL-online

    Rights statement: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

    Final published version, 2.77 MB, PDF document

    Available under license: CC BY: Creative Commons Attribution 4.0 International License

  • materials-09-00560-supplementary-information

    Rights statement: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

    Final published version, 6.02 MB, PDF document

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Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering. / Hardy, John George; Torres-Rendon, Jose Guillermo; Leal-Egana, Aldo et al.
In: Materials, Vol. 9, No. 7, 560, 11.07.2016.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hardy, JG, Torres-Rendon, JG, Leal-Egana, A, Walther, A, Schlaad, H, Cölfen, H & Scheibel, TR 2016, 'Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering', Materials, vol. 9, no. 7, 560. https://doi.org/10.3390/ma9070560

APA

Hardy, J. G., Torres-Rendon, J. G., Leal-Egana, A., Walther, A., Schlaad, H., Cölfen, H., & Scheibel, T. R. (2016). Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering. Materials, 9(7), Article 560. https://doi.org/10.3390/ma9070560

Vancouver

Hardy JG, Torres-Rendon JG, Leal-Egana A, Walther A, Schlaad H, Cölfen H et al. Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering. Materials. 2016 Jul 11;9(7):560. doi: 10.3390/ma9070560

Author

Hardy, John George ; Torres-Rendon, Jose Guillermo ; Leal-Egana, Aldo et al. / Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering. In: Materials. 2016 ; Vol. 9, No. 7.

Bibtex

@article{119e41388f3e48a6b7ef5c95b652dff2,
title = "Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering",
abstract = "Materials based on biodegradable polyesters such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT) have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein is reported the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.",
keywords = "spider silk, recombinant protein, biodegradable polymers, biomaterials, biomineralization, bone tissue engineering",
author = "Hardy, {John George} and Torres-Rendon, {Jose Guillermo} and Aldo Leal-Egana and Andreas Walther and Helmut Schlaad and Helmut C{\"o}lfen and Scheibel, {Thomas Rainer}",
year = "2016",
month = jul,
day = "11",
doi = "10.3390/ma9070560",
language = "English",
volume = "9",
journal = "Materials",
issn = "1996-1944",
publisher = "MDPI AG",
number = "7",

}

RIS

TY - JOUR

T1 - Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering

AU - Hardy, John George

AU - Torres-Rendon, Jose Guillermo

AU - Leal-Egana, Aldo

AU - Walther, Andreas

AU - Schlaad, Helmut

AU - Cölfen, Helmut

AU - Scheibel, Thomas Rainer

PY - 2016/7/11

Y1 - 2016/7/11

N2 - Materials based on biodegradable polyesters such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT) have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein is reported the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.

AB - Materials based on biodegradable polyesters such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT) have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein is reported the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.

KW - spider silk

KW - recombinant protein

KW - biodegradable polymers

KW - biomaterials

KW - biomineralization

KW - bone tissue engineering

U2 - 10.3390/ma9070560

DO - 10.3390/ma9070560

M3 - Journal article

VL - 9

JO - Materials

JF - Materials

SN - 1996-1944

IS - 7

M1 - 560

ER -