Home > Research > Publications & Outputs > Transient bioimpedance monitoring of mechanotra...

Electronic data


Text available via DOI:

View graph of relations

Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation

Research output: Contribution to Journal/MagazineJournal articlepeer-review

<mark>Journal publication date</mark>9/09/2014
<mark>Journal</mark>Journal of Electrical Bioimpedance
Number of pages20
Pages (from-to)55-74
Publication StatusPublished
<mark>Original language</mark>English


Mechanotransduction is of fundamental importance in cell physiology, facilitating sensing in touch and hearing as well as tissue development and wound healing. This study used an impedance sensor to monitor the effective resistance and permittivity of artificial tissues, alginate hydrogel with encapsulated fibroblasts, which were kept viable through the use of a bespoke microfluidic system. The observed transient impedance responses upon the application of identical compressive normal loads differed between acellular hydrogels and hydrogels in which fibroblasts were encapsulated. These differences resulted from changes in the conductivity and permeability of the hydrogel due to the presence of the encapsulated fibroblasts, and transient changes in ion concentrations due to mechanotransduction effects.