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Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation

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Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation. / Cheneler, David; Bowen, James; Kaklamani, Georgina.

In: Journal of Electrical Bioimpedance, Vol. 5, 09.09.2014, p. 55-74.

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Cheneler, David ; Bowen, James ; Kaklamani, Georgina. / Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation. In: Journal of Electrical Bioimpedance. 2014 ; Vol. 5. pp. 55-74.

Bibtex

@article{1d883c6a37954191892767f2f14cc551,
title = "Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation",
abstract = "Mechanotransduction is of fundamental importance in cell physiology, facilitating sensing in touch and hearing as well as tissue development and wound healing. This study used an impedance sensor to monitor the effective resistance and permittivity of artificial tissues, alginate hydrogel with encapsulated fibroblasts, which were kept viable through the use of a bespoke microfluidic system. The observed transient impedance responses upon the application of identical compressive normal loads differed between acellular hydrogels and hydrogels in which fibroblasts were encapsulated. These differences resulted from changes in the conductivity and permeability of the hydrogel due to the presence of the encapsulated fibroblasts, and transient changes in ion concentrations due to mechanotransduction effects.",
keywords = "Bioimpedance, mechanotransduction , cells , artificial skin , tissue engineering",
author = "David Cheneler and James Bowen and Georgina Kaklamani",
year = "2014",
month = sep,
day = "9",
doi = "10.5617/jeb.869",
language = "English",
volume = "5",
pages = "55--74",
journal = "Journal of Electrical Bioimpedance",
issn = "1891-5469",
publisher = "Oslo Bioimpedance Group, Department of Physics, University of Oslo",

}

RIS

TY - JOUR

T1 - Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation

AU - Cheneler, David

AU - Bowen, James

AU - Kaklamani, Georgina

PY - 2014/9/9

Y1 - 2014/9/9

N2 - Mechanotransduction is of fundamental importance in cell physiology, facilitating sensing in touch and hearing as well as tissue development and wound healing. This study used an impedance sensor to monitor the effective resistance and permittivity of artificial tissues, alginate hydrogel with encapsulated fibroblasts, which were kept viable through the use of a bespoke microfluidic system. The observed transient impedance responses upon the application of identical compressive normal loads differed between acellular hydrogels and hydrogels in which fibroblasts were encapsulated. These differences resulted from changes in the conductivity and permeability of the hydrogel due to the presence of the encapsulated fibroblasts, and transient changes in ion concentrations due to mechanotransduction effects.

AB - Mechanotransduction is of fundamental importance in cell physiology, facilitating sensing in touch and hearing as well as tissue development and wound healing. This study used an impedance sensor to monitor the effective resistance and permittivity of artificial tissues, alginate hydrogel with encapsulated fibroblasts, which were kept viable through the use of a bespoke microfluidic system. The observed transient impedance responses upon the application of identical compressive normal loads differed between acellular hydrogels and hydrogels in which fibroblasts were encapsulated. These differences resulted from changes in the conductivity and permeability of the hydrogel due to the presence of the encapsulated fibroblasts, and transient changes in ion concentrations due to mechanotransduction effects.

KW - Bioimpedance

KW - mechanotransduction

KW - cells

KW - artificial skin

KW - tissue engineering

U2 - 10.5617/jeb.869

DO - 10.5617/jeb.869

M3 - Journal article

VL - 5

SP - 55

EP - 74

JO - Journal of Electrical Bioimpedance

JF - Journal of Electrical Bioimpedance

SN - 1891-5469

ER -